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Topic Review
Speed Breeding for Crop Improvement and Food Security
Amid a rapidly growing global population and increasing threats to crop yields, Speed Breeding (SB) in crop genetics is focused. It traces SB’s development from carbon arc lamp experiments 150 years ago to its modern use with LED technology which significantly accelerates breeding cycles. SB has applications in genetic mapping, genetic modification, and trait stacking, enhancing crop resilience by leveraging allelic diversity. It aligns well with breeding methods like single plant selection and single seed descent. The integration of SB with gene editing, genotyping, and genomic selection holds great promise.
  • 1.3K
  • 14 Nov 2023
Topic Review
Chronic Dexamethasone Treatment
Neuroinflammation has been correlated with the progress of neurodegeneration in many neuropathologies. Although glial cells have traditionally been considered to be protective, the concept of them as neurotoxic cells has recently emerged. Thus, a major unsolved question is the exact role of astroglia and microglia in neurodegenerative disorders. On the other hand, it is well known that glucocorticoids are the first choice to regulate inflammation and, consequently, neuroglial inflammatory activity. The objective of this study was to determine how chronic dexamethasone treatment influences the host immune response and to characterize the beneficial or detrimental role of glial cells. To date, this has not been examined using a natural neurodegenerative model of scrapie. With this aim, immunohistochemical expression of glial markers, prion protein accumulation, histopathological lesions and clinical evolution were compared with those in a control group. Although impact of dexamethasone administration on neuropathological lesions was not demonstrated and treatment did not seem to be clinically relevant to disease progress when clinical signs had already begun, the evident extension of survival in one case was hopeful. The findings presented in this study support a potential failure of astrocytes and a stimulation of phagocytosis of PrPsc deposits by microglia. Thus, it is evidenced here how the complex interaction between glial populations failed to compensate for brain damage in natural conditions, emphasizing the need for using natural models. Additionally, the data showed that modulation of neuroinflammation by anti-inflammatory drugs might become a research focus as a potential therapeutic target for prion diseases, similar to that considered previously for other neurodegenerative disorders classified as prion-like diseases.
  • 1.3K
  • 28 Oct 2020
Topic Review
Antimicrobial Stewardship in Clinical Practice
“Antimicrobial stewardship” is a strategy that promotes the responsible use of antimicrobials. The objective of this paper is to focus on consolidated and more recent improvements in clinical strategies that should be adopted in hospitalized patients to ameliorate their infectious diseases’ outcome and to reduce the antibiotic resistance risk through judicious use of antibiotics. We present 13 common clinical scenarios, the respective suggested interventions and the explanations of the supporting evidence, in order to help clinicians in their decision-making process. Strategies including the choice of antibiotic and dose optimization, antibiotic spectrum narrowing (de-escalation), shortening of duration, shift to oral route or outpatient parenteral antibiotic (including elastomeric pumps), and biomarkers are described and discussed.
  • 1.3K
  • 22 Jul 2020
Topic Review
Small Ruminant Production
The background and context of Small Ruminant production on rangelands is presented.
  • 1.3K
  • 27 Oct 2020
Topic Review
Titanium porous bone regeneration scaffold
Additive manufacturing facilitates the design of porous metal implants with detailed internal architecture. A rationally designed porous structure can provide to biocompatible titanium alloys biomimetic mechanical and biological properties for bone regeneration. However, increased porosity results in decreased material strength. The porosity and pore sizes that are ideal for porous implants are still controversial in the literature, complicating the justification of a design decision. Recently, metallic porous biomaterials have been proposed for load-bearing applications beyond surface coatings. This recent science lacks standards, but the Quality by Design (QbD) system can assist the design process in a systematic way.
  • 1.3K
  • 17 Nov 2020
Topic Review
CARASIL
Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy, commonly known as CARASIL, is an inherited condition that causes stroke and other impairments.
  • 1.3K
  • 04 Jan 2021
Topic Review
Pulse Oximetry
Finger pulse oximeters are widely used to monitor physiological responses to high-altitude exposure, the progress of acclimatization, and/or the potential development of high-altitude related diseases. 
  • 1.3K
  • 24 Feb 2021
Topic Review
Senolytics for Cancer Therapy
Senolytics represent a group of mechanistically diverse drugs that can eliminate senescent cells, both in tumors and in several aging-related pathologies. Consequently, senolytic use has been proposed as a potential adjuvant approach to improve the response to senescence-inducing conventional and targeted cancer therapies. However, the translation of senolytics to the clinic faces many challenges that need to be addressed by the research community. 
  • 1.3K
  • 09 Mar 2021
Topic Review
Digital Twins for Tissue Culture
Digital twins in the field of tissue culture include the mechanistic of the biological system in the form of diverse mathematical models, which describe the interaction between tissue culture techniques and cell growth, metabolism, and the quality of the tissue.
  • 1.3K
  • 08 Apr 2021
Topic Review
Spatiotemporal Release of Anticancer Drugs
To overcome cancer, various chemotherapeutic studies are in progress; among these, studies on nano-formulated combinatorial drugs (NFCDs) are being actively pursued. NFCDs function via a fusion technology that includes a drug delivery system using nanoparticles as a carrier and a combinatorial drug therapy using two or more drugs. It not only includes the advantages of these two technologies, such as ensuring stability of drugs, selectively transporting drugs to cancer cells, and synergistic effects of two or more drugs, but also has the additional benefit of enabling the spatiotemporal and controlled release of drugs. This spatial and temporal drug release from NFCDs depends on the application of nanotechnology and the composition of the combination drug. 
  • 1.3K
  • 05 Apr 2021
Topic Review
Chitosan-Based Particles for Biomedical Applications
Marine-derived chitosan (CS) is a cationic polysaccharide widely studied for its bioactivity, which is mostly attached to its primary amine groups. CS is able to neutralize reactive oxygen species (ROS) from the microenvironments in which it is integrated, consequently reducing cell-induced oxidative stress. It also acts as a bacterial peripheral layer hindering nutrient intake and interacting with negatively charged outer cellular components, which lead to an increase in the cell permeability or to its lysis. Its biocompatibility, biodegradability, ease of processability (particularly in mild conditions), and chemical versatility has fueled CS study as a valuable matrix component of bioactive small-scaled organic drug-delivery systems, with current research also showcasing CS’s potential within tridimensional sponges, hydrogels and sutures, blended films, nanofiber sheets and fabric coatings.
  • 1.3K
  • 30 Jun 2021
Topic Review
MDS
Myelodysplastic syndromes (MDS) represent a heterogeneous group of clonal disorders caused by sequential accumulation of somatic driver mutations in hematopoietic stem and progenitor cells (HSPCs). MDS is characterized by ineffective hematopoiesis with cytopenia, dysplasia, inflammation, and a variable risk of transformation into secondary acute myeloid leukemia.
  • 1.3K
  • 22 Sep 2021
Topic Review
Role of Coenzyme Q
Coenzyme Q is a unique lipidic molecule highly conserved in evolution and essential to maintaining aerobic metabolism. It is endogenously synthesized in all cells by a very complex pathway involving a group of nuclear genes that share high homology among species. This pathway is tightly regulated at transcription and translation, but also by environment and energy requirements. Dysfunction in CoQ synthesis produces mitochondrial diseases that can partially reverted by CoQ supplementation. The main function of CoQ10 in human metabolism and antioxidant protection of membranes against oxidation and ferroptosis makes CoQ10 as an essential factor in many metabolic, chronic diseases and also in aging.
  • 1.3K
  • 29 Mar 2022
Topic Review
Antisense Oligonucleotide-Mediated Splice Switching
Antisense oligonucleotides (AOs) have been developed to inhibit the production of alternatively spliced carcinogenic isoforms through splice modulation or mRNA degradation. AOs can also be used to induce splice switching, where the expression of an oncogenic protein can be inhibited by the induction of a premature stop codon. In general, AOs are modified chemically to increase their stability and binding affinity. One of the major concerns with AOs is efficient delivery. Strategies for the delivery of AOs are constantly being evolved to facilitate the entry of AOs into cells. 
  • 1.3K
  • 25 Nov 2021
Topic Review
Flavonoids Composition in Astragalus membranaceus
Astragalus membranaceus is a valuable medicinal plant species widely distributed in Asia. Its root is the main medicinal tissue rich in methoxylated flavonoids. Origin can highly influence the chemical composition and bioactivity.
  • 1.3K
  • 09 Dec 2021
Topic Review
Interventions That Reduced Adults Salt Intake
Excessive sodium in the diet increases blood pressure and therefore increases the risk of cardiovascular diseases. Reducing sodium intake is important to lower blood pressure and thus reduce cardiovascular diseases and other complications associated with high sodium intake, such as chronic kidney disease, obesity, gastric cancer and liver diseases. 
  • 1.3K
  • 08 Feb 2022
Topic Review
Isolation of Circulating Tumor Cells by Microfluidic Devices
During metastasis, cancer cells detach from the primary tumor and intrude apart into tissues in the bloodstream. To detect and isolate CTCs (circulating tumor cells), various techniques including centrifugation, magnetic separation, microchips, filtration, micro/nano substrates and biomarkers have been used. With the widespread adoption of microfluidic techniques, a large number of researchers have worked hard to develop more efficient and reliable CTC separation technologies ranging from immunomagnetic beads to size-based microfluidic devices. Currently, the major commercialised products for CTC separation techniques include the CellSearch system, which uses immunomagnetic beads, and the CelarCellFX1 system, which uses size-dependent isolation. The methods for isolating CTCs are mostly based on biological qualities of the tumor cells, such as specific antigen expression and receptor, or physical properties of the tumor cells, such as size and deformability. Inertial focusing, acoustics, microfluidic filters, optics and dielectrophoresis are some of the size and deformability-based approaches.
  • 1.3K
  • 27 Apr 2022
Topic Review
Generation Nanobubbles in Flotation
Nanobubbles (NBs), also known as ultrafine bubbles, are extremely small (finer than 1 µm) and have several unique physical and physicochemical properties, making them very different from sub-micron (SMBs < 50 µm), micro- (MBs, 50–1000 µm) and conventional air bubbles (CBs, >1000 µm). They can be categorized into surface NBs (formed at solid–liquid interfaces), bulk NBs (exist in bulk liquid and are spherical with a typical diameter of 100–200 nm), and micro-pancakes (quasi-two-dimensional gaseous domains).
  • 1.3K
  • 11 May 2022
Topic Review
Resilience and Systems
Resilience is a growing area of interest and study, but it has a variety of origins and apparent inconsistencies across disciplines. 
  • 1.3K
  • 11 Jul 2022
Topic Review
Soft X-ray Contact Microscopy
Soft X-ray microscopy is a powerful technique for imaging cells with nanometer resolution in their native state without chemical fixation, staining, or sectioning.
  • 1.3K
  • 21 Jul 2022
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