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Topic Review
Climate-Adaptive Construction
Creating climate-adaptive energy-efficient structures is also facilitated by using innovative materials, such as phase-change materials (PCM). The energy-saving potential was considered using the example of a three-story office building in China. It was modeled under different climatic conditions. The energy-saving potential of Shenyang, located in a harsh cold climate, was the most sustainable. 
  • 1.3K
  • 01 Apr 2022
Topic Review
RDW Change in Heart Failure
Red blood cell distribution width (RDW) is an integral parameter of the complete blood count (CBC), which has been traditionally used for the classification of several types of anemia. It has been defined either as the standard deviation (SD) of erythrocyte volumes (RDW-SD), which is measured by calculating the width at the 20% height level of the red blood cell (RBC) size distribution histogram; or, as the coefficient of variation (RDW-CV) of erythrocyte volumes by dividing the standard deviation (SD) of the red blood cell volume (RBCs) by the mean corpuscular volume (MCV) multiplied by 100 (SD/MCV × 100), and expressing the variability in size of circulating erythrocytes (anisocytosis). The normal reference ranges of RDW-SD and RDW-CV are typically 39–46 fL and 11.5–15%, respectively, but often vary depending on the method of RDW calculation and the available hematological analyzers used.
  • 1.3K
  • 18 Apr 2022
Topic Review
Modelling Energy Transition in Germany
The expression energy transition indicates a long-term structural change in energy systems. It is not a new phenomenon: man has made several energy transitions in his short history on Earth. One of the most significant was shifting to an energy system based on fossil fuels (coal, oil, and natural gas) from one essentially based on wood; however, since the 1980s, it has been realized that fossil fuels are at the root of climate change due to carbon emissions into the atmosphere.
  • 1.3K
  • 20 Apr 2022
Topic Review
L-Carnitine and Balanced Diet in Alzheimer’s Disease
The prevention or alleviation of neurodegenerative diseases, including Alzheimer’s disease (AD), is a challenge for contemporary health services. For the prevention or alleviation of AD by introducing an appropriate carnitine-rich diet, dietary carnitine supplements and the MIND (Mediterranean-DASH Intervention for Neurodegenerative Delay) diet, it contains elements of the Mediterranean diet and the Dietary Approaches to Stop Hypertension (DASH) diet. L-carnitine (LC) plays a crucial role in the energetic metabolism of the cell. A properly balanced diet contains a substantial amount of LC as well as essential amino acids and microelements taking part in endogenous carnitine synthesis. In healthy people, carnitine biosynthesis is sufficient to prevent the symptoms of carnitine deficiency.
  • 1.3K
  • 16 May 2022
Topic Review
Techniques for Micro(Nano)Plastics Measurement
Plastics have been massively produced since the 1940s, when society started to consume large quantities of plastics in every segment of our lives, including industry, agriculture, healthcare, and others. The production of plastics has been expanded in the last decades because of their favored characteristics, such as lightness, durability, flexibility, versatility, and cost-effectiveness.
  • 1.3K
  • 14 Nov 2022
Topic Review
Non-Intrusive Load Monitoring for Energy Management Systems
Load monitoring systems make it possible to obtain information on the status of the various loads powered by an electrical system. The term “electrical load” indicates any device or circuit that absorbs energy from the system to which it is connected, and which therefore influences electrical quantities such as power, voltage, and current. These monitoring systems, designed for applications related to energy efficiency, can also be used in other applications. The information derived from Non-Intrusive Load Monitoring (NILM) systems can be used in order to create Energy Management Systems (EMS), Demand Response (DR), anomaly detection, maintenance, and Ambient Assisted Living (AAL). An EMS allows the user to measure and control the use and production of energy within a plant. Due to the benefits offered to both the consumers and distributors of electricity, EMSs are becoming increasingly important for reducing consumption.
  • 1.3K
  • 16 Dec 2022
Topic Review
Potential Association of Cutibacterium acnes with Sarcoidosis
The immunohistochemical detection of Cutibacterium acnes in sarcoid granulomas suggests its potential role in granuloma formation. C. acnes is the sole microorganism ever isolated from sarcoid lesions. Histopathologic analysis of some sarcoid lymph nodes reveals latent infection and intracellular proliferation of cell-wall-deficient C. acnes followed by insoluble immune-complex formation. Activation of T helper type 1 (Th1) immune responses by C. acnes is generally higher in sarcoidosis patients than in healthy individuals. Pulmonary granulomatosis caused by an experimental adjuvant-induced allergic immune response to C. acnes is preventable by antimicrobials, suggesting that the allergic reaction targets C. acnes commensal in the lungs. C. acnes is the most common bacterium detected intracellularly in human peripheral lungs and mediastinal lymph nodes. In predisposed individuals with hypersensitive Th1 immune responses to C. acnes, granulomas may form to confine the intracellular proliferation of latent C. acnes triggered by certain host-related or drug-induced conditions. 
  • 1.3K
  • 31 Jan 2023
Topic Review
Sirt3 and Neurodegenerative Diseases
An NAD+-dependent deacetylase called Sirtuin 3 (Sirt3) is involved in the metabolic processes of the mitochondria, including energy generation, the tricarboxylic acid cycle, and oxidative stress. Sirt3 activation can slow down or prevent mitochondrial dysfunction in response to neurodegenerative disorders, demonstrating a strong neuroprotective impact. The mechanism of Sirt3 in neurodegenerative illnesses has been elucidated over time; it is essential for neuron, astrocyte, and microglial function, and its primary regulatory factors include antiapoptosis, oxidative stress, and the maintenance of metabolic homeostasis. Sirt3 plays a key part in the central nervous system (CNS)  and participates in the regulation of the physiological and pathological functions of various nerve cells. Many of these mechanisms are closely related to neurodegeneration, implying that Sirt3 is a key regulatory molecule in neurodegenerative diseases.
  • 1.3K
  • 15 May 2023
Topic Review
Food Waste and the Circular Economy
Food waste is a global issue with significant economic, social, and environmental impacts. Addressing this problem requires a multifaceted approach; one promising avenue is using artificial intelligence (AI) technologies.
  • 1.3K
  • 13 Jul 2023
Topic Review
Parking Demand Prediction Framework
With the development of smart cities and smart transportation, cities can gradually provide people with more information to facilitate their life and travel, and parking is also inseparable from both of them. Accurate on-street parking demand prediction can improve parking resource utilization and parking management efficiency, as well as potentially improve urban traffic conditions.
  • 1.3K
  • 13 Jul 2023
Topic Review
Organic Rankine Cycles and Absorption Cooling Systems
One of the main consequences of the irrational use of energy systems, mainly of those with direct or indirect use of fossil fuels, is climate change, whose effects on the planet have been studied in recent decades and today are well known. In the last decades, a strategy well promoted to counteract such effects is the transition to systems using renewable energy sources, such as solar energy, which can be used to produce electricity through the well-known photovoltaic technologies, or heat through the different solar thermal devices. These energy sources are of interest to the present research work.
  • 1.3K
  • 01 Mar 2024
Topic Review
Smart Window
Dimming and scattering control are two of the major features of smart windows, which provide adjustable sunlight intensity and protect the privacy of people in a building. A hybrid photo- and electrical-controllable smart window that exploits salt and photochromic dichroic dye-doped cholesteric liquid crystal was developed. The photochromic dichroic dye causes a change in transmittance from high to low upon exposure to sunlight. When the light source is removed, the smart window returns from colored to colorless. The salt-doped cholesteric liquid crystal can be bi-stably switched from transparent into the scattering state by a low-frequency voltage pulse and switched back to its transparent state by a high-frequency voltage pulse. In its operating mode, an LC smart window can be passively dimmed by sunlight and the haze can be actively controlled by applying an electrical field to it; it therefore exhibits four optical states—transparent, scattering, dark clear, and dark opaque. Each state is stable in the absence of an applied voltage. This smart window can automatically dim when the sunlight gets stronger, and according to user needs, actively adjust the haze to achieve privacy protection.
  • 1.3K
  • 22 Oct 2020
Topic Review
Leading Edge Cuff
A leading edge cuff is a fixed aerodynamic wing device employed on fixed-wing aircraft to improve the stall and spin characteristics. Cuffs may be either factory-designed or an after-market add-on modification. A leading edge cuff is a wing leading edge modification, usually a lightly drooped outboard leading-edge extension. In most cases of outboard leading edge modification, the wing cuff starts about 50–70% half-span and spans the outer leading edge of the wing. The main goal is to produce a more gradual and gentler stall onset, without any spin departure tendency, particularly where the original wing has a sharp/asymmetric stall behaviour with a passive, non-moving, low-cost device that would have a minimal impact on performance. A further benefit is to lowering stall speed, with lower approach speeds and shorter landing distances. They may also, depending on cuff location, improve aileron control at low speed.
  • 1.3K
  • 18 Oct 2022
Topic Review
Molecular Biology of Toona sinensis
Toona sinensis belongs to the Meliaceae family and is commonly called Chinese toon or Chinese mahogany. Young leaves and buds of T. sinensis plants are excellent source of flavonoids, terpenoids, phenylpropanoids, and more. In addition, the bioactive components of T. sinensis possess numerous health benefits, such as antiviral, antioxidant, anti-cancer, anti-inflammatory, and hypoglycemic effects. 
  • 1.3K
  • 19 Jul 2022
Topic Review
Stabilin-2 and Cancer Metastasis
Stabilin-2 is a systemic clearance receptor for hyaluronic acid (HA).  HA is typically enriched in the extracellular matrix of several types of cancer cells, thus, Stabilin-2 may interact with the extracellular matrix of cancer cells depending on the physiological environment of the tissue.  This is especially relevant for the liver sinusoids and lymph nodes which express high levels of Stabilin-2 and also are sites of metastases for a number of cancer types.
  • 1.3K
  • 28 Oct 2020
Topic Review
Air Pollution Induced Disorders
Air pollution is a heterogeneous mixture of various constituents resulting from the complex interaction of multiple emissions and chemical reactions. This mixture comprises solid particles and liquid droplets suspended in the air, i.e., PM2.5, that can include organic carbon (OC), elemental or black carbon (EC), nitrates, sulfates, and metals (e.g., iron, vanadium, nickel, copper, and manganese) as well as gases (e.g., ground level ozone (O3), carbon monoxide (CO), sulfur dioxide (SO2), oxides of nitrogen (NOx)) gaseous organic compounds (e.g., non-methane volatile organic compounds (VOCs), polycyclic aromatic hydrocarbons (PAHs) and polychlorinated biphenyls (PCBs)), bacterial endotoxins (mostly bound to solid particles or liquid aerosols). There are two possible ways by which air pollutants enter the CNS, either through direct transport of particles into the CNS or via systemic inflammation upon initial recruitment of immune cells in the lung tissue. Once in the organism, the adverse effects of fine particulates on the brain rely mainly on three mechanisms. First, they can induce the release of proinflammatory mediators leading to chronic respiratory and systemic inflammation, thereby affecting the BBB and ultimately triggering neural-immune interaction and resulting in increased production of ROS and chronic oxidative stress. Second, the particles can damage the BBB through the direct formation of ROS and thereby alter the permeability of the barrier. Third, there can be mechanical stimulation of specific mechano-receptors in pulmonary tissue leading to the lung arc reflex and sympathetic activation with the release of vasoconstrictors such as catecholamines. 
  • 1.3K
  • 26 Oct 2020
Topic Review
ARID1B Gene
AT-rich interaction domain 1B
  • 1.3K
  • 24 Dec 2020
Topic Review
Natural Compounds and Prostate Cancer
Prostate cancer (PCa) represents a major cause of cancer mortality among men in developed countries. Patients with recurrent disease initially respond to androgen-deprivation therapy, but the tumor eventually progresses into castration-resistant PCa; in this condition, tumor cells acquire the ability to escape cell death and develop resistance to current therapies. Thus, new therapeutic approaches for PCa management are urgently needed. In this setting, natural products have been extensively studied for their anti-PCa activities, such as tumor growth suppression, cell death induction, and inhibition of metastasis and angiogenesis.
  • 1.3K
  • 04 Jun 2021
Topic Review
Mirizzi Syndrome
Mirizzi syndrome is a rare condition caused by the compression of the common hepatic duct due to stones located in the cystic duct or the neck of the gallbladder, which causes obstruction of the extrahepatic biliary tract, what is most commonly presented as jaundice and upper abdominal pain. Mirizzi syndrome occurs approximately in 0.05-4% of patients undergiong cholecystectomy. Prolonged inflammation caused by the stones impacted in the cystic duct or the neck of the gallbladder may lead to advanced stages of Mirizzi syndrome and the formation of a cholecystocholedochal fistula or even a cholecystoenteric fistula. Diagnosis is made upon the symptoms, laboratory results and imaging techniques such as ultrasonography, computed tomography, magnetic resonance imaging or endoscopic retrograde choleangiopancreatography (ERCP), which is considered as the golden standard. However, the preoperative diagnosis is difficult and a large part of all cases is diagnosed intraoperatively. Management of Mirizzi syndrome is mostly surgical, but early stages of the syndrome can be treated with the use of ERCP.  
  • 1.3K
  • 17 Sep 2021
Topic Review
Wickerhamomyces Yeast Killer Toxins
Bacteriocins are ribosomally synthesized antimicrobial peptides produced from a wide variety of bacteria that inhibit the growth of similar or closely related bacterial strains. A similar phenomenon of competition is present in yeasts, based on the production of killer toxins (KTs, or mycocins) that are secreted proteins or glycoproteins capable of killing susceptible microorganisms with various mechanisms of action, through interaction with specific superficial receptors. Possible implications and applications of the yeast killer phenomenon in the fight against infectious diseases are reviewed in this work, with particular reference to some wide-spectrum killer toxins (KTs) produced by Wickerhamomyces anomalus and other related species. 
  • 1.3K
  • 15 Oct 2021
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