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Topic Review
Coupled Dynamic Performance of Floating Offshore Wind Turbines
Floating offshore wind turbines (FOWT) have attracted more and more attention. Environmental loads on FOWTs have higher complexity than those on the traditional onshore or fixed-bottom offshore wind turbines. In addition to aerodynamic loads on turbine blades, hydrodynamic loads also act on the support platform. The primary coupling method is based on the combination of BEM theory and potential flow theory, which can simulate the performance of the FOWT system under normal operating conditions but has certain limitations in solving the complex problem of coupled FOWTs. The more accurate and reliable CFD method used in the research of coupling problems is still in its infancy.
  • 1.3K
  • 10 Jun 2022
Topic Review
Rooftop Solar Photovoltaic Systems
Rooftop solar photovoltaic (PV) retrofitting can greatly reduce the emissions of greenhouse gases, thus contributing to carbon neutrality. Retrofitting distributed rooftops with solar PV is an effective means of promoting “carbon peaking” and “carbon neutral” strategies. Rooftop solar PV is geographically unrestricted. The PV cells can be closely integrated into buildings without taking up additional land resources, not only saving land resources but also improving their utilization rate.
  • 1.3K
  • 12 Jul 2022
Topic Review
Obesity, Pregnancy and the Social Contract with Adolescents
Adolescent health and well-being are of great concern worldwide, and adolescents encounter particular challenges, vulnerabilities and constraints. The dual challenges of adolescent parenthood and obesity are of public health relevance because of the life-altering health and socioeconomic effects on both the parents and the offspring. Prevention and treatment strategies at the individual and population levels have not been successful in the long term, suggesting that adolescent pregnancy and obesity cannot be managed by more of the same. Here, the researchers view adolescent obese pregnancy through the lens of the social contract with youth. The disruption of this contract is faced by today’s adolescents, with work, social and economic dilemmas which perpetuate socioeconomic and health inequities across generations. The lack of employment, education and social opportunities, together with obesogenic settings, increase vulnerability and exposure to lifelong health risks, affecting their offspring’s life chances too. To break such vicious circles of disadvantage and achieve sustainable solutions in real-world settings, strong efforts on the part of policymakers, healthcare providers and the community must be oriented towards guaranteeing equity and healthy nutrition and environments for today’s adolescents. The involvement of adolescents themselves in developing such programs is paramount, not only so that they feel a sense of agency but also to better meet their real life needs. 
  • 1.3K
  • 13 Sep 2022
Topic Review
Machine Learning-Based Application Life-Cycle
The application of emerging technologies, such as Artificial Intelligence (AI), entails risks that need to be addressed to ensure secure and trustworthy socio-technical infrastructures. Machine Learning (ML), the most developed subfield of AI, allows for improved decision-making processes. ML models exhibit specific vulnerabilities that conventional IT systems are not subject to. As systems incorporating ML components become increasingly pervasive, the need to provide security practitioners with threat modeling tailored to the specific AI-ML pipeline is of paramount importance.
  • 1.3K
  • 21 Sep 2022
Topic Review
Heterocyclic PPAR Ligands for Potential Therapeutic Applications
The family of nuclear peroxisome proliferator-activated receptors (PPARα, PPARβ/δ, and PPARγ) is a set of ligand-activated transcription factors that regulate different functions in the body. Whereas activation of PPARα is known to reduce the levels of circulating triglycerides and regulate energy homeostasis, the activation of PPARγ brings about insulin sensitization and increases the metabolism of glucose. On the other hand, PPARβ when activated increases the metabolism of fatty acids. Further, these PPARs have been claimed to be utilized in various metabolic, neurological, and inflammatory diseases, neurodegenerative disorders, fertility or reproduction, pain, and obesity.
  • 1.3K
  • 08 Nov 2022
Topic Review
Amino Acids in Cancer
Cancer metabolism is an emerging field of investigation aimed at identifying cancer cell vulnerabilities in order to define novel anti-cancer therapeutic approaches based on interventions that modulate the availability of specific nutrients. Amino acids (AAs) are used by cancer cells as both building blocks for protein synthesis required for rapid tumor growth and as sources of energy. 
  • 1.3K
  • 06 Dec 2022
Topic Review
Structures of Mechanoresponsive Smart Windows
Mechanically responsive smart windows have the advantages of simple structure, low cost and good stability.
  • 1.3K
  • 06 Mar 2023
Topic Review
All-Russian Collection of Plant Cell Cultures
The collections of plant cell cultures maintained in vitro are valuable sources of strains with unique ecological and biotechnological traits. Such collections play a vital role in bioresource conservation, science, and industry development. Here is an overview of All-Russian Collection of Plant Cell Cultures at the Institute of Plant Physiology of the Russian Academy of Sciences (IPPRAS). The total collection holdings comprise about 120 cell cultures of medicinal and model plant species. Several plant cell culture strains have been adapted for cultivation in bioreactors from laboratory (5–20-L) to pilot (75-L) to semi-industrial (630-L) scale for the production of biomass with high nutritive or pharmacological value. Some of the strains with proven biological activities are currently used to produce cosmetics and food supplements. Here is also provided a brief information on the current collection composition and major activities, their use in research, biotechnology, and commercial application. The most interesting studies performed with collection strains were highlighted.
  • 1.3K
  • 04 Jul 2023
Topic Review
Pathogenesis of Iron Overload and Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is one of the most common malignancies in both transfusion-dependent thalassemia (TDT) and non-transfusion-dependent thalassemia (NTDT). The mechanisms of iron-overloading-associated HCC development include the increased reactive oxygen species (ROS), inflammation cytokines, dysregulated hepcidin, and ferroportin metabolism.
  • 1.3K
  • 15 Aug 2023
Topic Review
Social Vulnerability to Floods in Malaysia
Flood disasters, a natural hazard throughout human history, have caused significant damage to human safety and infrastructure. Demographic characteristics, socioeconomic status, and access to healthcare crucially determine social vulnerability to adverse flood events. 
  • 1.3K
  • 08 Sep 2023
Topic Review
Ytterbium Fluoride in Dental Materials
The compound ytterbium trifluoride is used as a component of several dental materials. Ytterbium trifluoride is reported to be insoluble in water. Despite this, its presence is associated with fluoride release from dental materials. There is evidence that it reacts with the components of calcium trisilicate cements to form small amounts of a variety of compounds, including ytterbium oxide, Yb2O3, and calcium–ytterbium fluoride, CaYbF5. In nanoparticulate form, it has been shown to reinforce glass polyalkenoates and it also provides high contrast in X-ray images.
  • 1.3K
  • 12 Jan 2024
Topic Review
Fungal Carotenoids
Carotenoids represent a class of pigmented terpenoids. They are distributed in all taxonomic groups of fungi. Most of the fungal carotenoids differ in their chemical structures to those from other organisms. The general function of carotenoids in heterotrophic organisms is protection as antioxidants against reactive oxygen species generated by photosensitized reactions. Furthermore, carotenoids are metabolized to apocarotenoids by oxidative cleavage.
  • 1.3K
  • 14 Mar 2022
Topic Review
Thoracentesis for the Management of Pleural Effusions
Pleural effusion refers to the accumulation of fluid in the pleural space, which can occur due to various underlying medical conditions. It is a relatively common finding, with approximately 1.5 million cases reported annually in the United States. Common causes include congestive heart failure, bacterial pneumonia, and malignancy. Thoracentesis, also known as needle thoracostomy or pleural tap, was first described by American physician Henry Ingersoll Bowditch in 1852 and involves the removal of excess pleural fluid for diagnostic and therapeutic purposes. It is often the preferred initial procedure for diagnosis and management of pleural effusions, with approximately 178,000 thoracenteses performed in the United States annually.
  • 1.3K
  • 19 Dec 2023
Topic Review
Pathogenetic Mechanisms of Hypertension–Brain-Induced Complications
Hypertension is well known to alter the structure and function of cerebral blood vessels not only through its haemodynamics effects but also for its relationships with endothelial dysfunction, oxidative stress and inflammation.
  • 1.3K
  • 09 Mar 2022
Topic Review
Ergonomics Evaluation Using Motion Capture Technology
Due to the increasingly high proportion of manual activities in production processes, there is a constant risk of musculoskeletal disorders or work-related injuries. The risk of these problems is exacerbated by the trend towards an ageing working population. European legislation is pressing for improved working conditions to eliminate the risks associated with health problems for workers. For this reason, the application of ergonomics in this field is growing. Musculoskeletal disorders, which are most often caused by inappropriate working postures, are a major problem. There are many methods for evaluating working postures. 
  • 1.3K
  • 06 Jan 2023
Topic Review
Wireless Communications and Power Transfer on Intra-Vehicular Applications
In the world of space systems and launchers in particular, there is always a strong demand for the reduction of the weight of all components/subsystems that are not related to the payload and simplification of the integration phase. A possible solution to both these problems is the replacement of cables and connectors with wireless systems for communication and power supply. 
  • 1.3K
  • 18 Feb 2024
Topic Review
Communicable Diseases in Roma Communities
The Roma are Europe's largest minority. They are also one of its most disadvantaged, with low levels of education and health, and high levels of poverty. This entry focuses on Eastern and Central Europe, and summarises the findings of a review of 19 papers that describe communicable disease burden among the Roma. Roma in Eastern and Central Europe continue to have a higher prevalence of communicable diseases than the majority populations of the countries they live in, and are at a high risk of infection.
  • 1.3K
  • 26 Nov 2020
Topic Review
Genomics in Dairy Cattle Selection
Genomics comprises a set of current and valuable technologies implemented as selection tools in dairy cattle commercial breeding programs. The intensive progeny testing for production and reproductive traits based on genomic breeding values (GEBVs) has been crucial to increasing dairy cattle productivity. The knowledge of key genes and haplotypes, including their regulation mechanisms, as markers for productivity traits, may improve the strategies on the present and future for dairy cattle selection. Genome-wide association studies (GWAS) such as quantitative trait loci (QTL), single nucleotide polymorphisms (SNPs), or single-step genomic best linear unbiased prediction (ssGBLUP) methods have already been included in global dairy programs for the estimation of marker-assisted selection-derived effects. The increase in genetic progress based on genomic predicting accuracy has also contributed to the understanding of genetic effects in dairy cattle offspring. However, the crossing within inbred-lines critically increased homozygosis with accumulated negative effects of inbreeding like a decline in reproductive performance. Thus, inaccurate-biased estimations based on empirical-conventional models of dairy production systems face an increased risk of providing suboptimal results derived from errors in the selection of candidates of high genetic merit-based just on low-heritability phenotypic traits. This extends the generation intervals and increases costs due to the significant reduction of genetic gains. 
  • 1.3K
  • 29 Apr 2021
Topic Review
NMDA Receptors in Astrocytes
Studies of the last two decades have demonstrated the presence in astrocytic cell membranes of N-methyl-d-aspartate (NMDA) receptors (NMDARs), albeit their abundance in astrocytes appears to be strikingly lower than of other glutamate (Glu) receptor classes. Recent advancements in visualization techniques have enabled convincing demonstration of the activation of astrocytic NMDARs directly in brain slices and in acutely isolated or cultured astrocytes, by monitoring intracellular calcium increase. Astrocytic NMDARs are activated by mutually unexclusive ionotropic and metabotropic mechanisms.
  • 1.3K
  • 30 Apr 2021
Topic Review
12-Lipoxygenases
Lipoxygenases (LOXs) are lipid metabolizing enzymes that catalyze the di-oxygenation of polyunsaturated fatty acids to generate active eicosanoid products. 12-lipoxygenases (12-LOXs) primarily oxygenate the 12th carbon of its substrates. 
  • 1.3K
  • 26 Aug 2021
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