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Topic Review
CRISPR-Cas Genome Editing Components in C. elegans
CRISPR-Cas allows us to introduce desired genome editing, including mutations, epitopes, and deletions, with unprecedented efficiency. The development of CRISPR-Cas has progressed to such an extent that it is now applicable in various fields, with the help of model organisms. C. elegans is one of the pioneering animals in which numerous CRISPR-Cas strategies have been rapidly established. Ironically, the emergence of numerous methods makes the choice of the correct method difficult. Choosing an appropriate selection or screening approach is the first step in planning a genome modification.
  • 5.4K
  • 30 Dec 2022
Topic Review
Sunday Shopping
Sunday shopping, also called Sunday trading, refers to the ability of retailers to operate stores on Sunday, a day that Christian tradition typically recognises as a day of rest. Rules governing shopping hours, such as Sunday shopping, vary around the world and some countries and subnational jurisdictions ban or restrict Sunday shopping.
  • 5.4K
  • 22 Nov 2022
Topic Review
Delphi (IDE)
Delphi is an integrated development environment (IDE) for rapid application development of desktop, mobile, web, and console software, developed by Embarcadero Technologies. It is also an event-driven language. Delphi's compilers use their own Object Pascal dialect of Pascal and generate native code for Microsoft Windows, macOS (IA-32 only), iOS, Android and Linux (x64 only). Since 2016, there have been new releases of Delphi every six months, with new platforms being added approximately every second release. Delphi includes a code editor, a visual designer, an integrated debugger, a source code control component, and support for third-party plugins. The code editor features Code Insight (code completion), Error Insight (real-time error-checking), and refactoring. The visual forms designer has traditionally used Visual Component Library (VCL) for native Windows development, but the FireMonkey (FMX) platform was later added for cross-platform development. Database support in Delphi is very strong. A Delphi project of a million lines to compile in a few seconds – one benchmark gave 170,000 lines per second. Delphi was originally developed by Borland as a rapid application development tool for Windows as the successor of Turbo Pascal. Delphi added full object-oriented programming to the existing language, and since then the language has grown to support generics and anonymous methods, and native Component Object Model (COM) support. In 2006, Borland’s developer tools section was transferred from Borland to a wholly owned subsidiary known as CodeGear, which was sold to Embarcadero Technologies in 2008. In 2015, Embarcadero was purchased by Idera Software, but the Embarcadero mark was retained for the developer tools division. Delphi and its C++ counterpart, C++Builder, are interoperable. They share many core components, notably the IDE, VCL, and much of the runtime library. In addition, they can be used jointly in a project. For example, C++Builder 6 and later can consume Delphi source code and C++ in one project, while packages compiled with C++Builder can be used from within Delphi. In 2007, the products were released jointly as RAD Studio, a shared host for Delphi and C++Builder, which can be purchased with either or both.
  • 5.4K
  • 02 Nov 2022
Topic Review
Newspeak
Newspeak is the language of Oceania, a fictional totalitarian state and the setting of the dystopian novel Nineteen Eighty-Four (1949), by George Orwell. To meet the ideological requirements of English Socialism (Ingsoc) in Oceania, the ruling Party created Newspeak, a controlled language of restricted grammar and limited vocabulary, meant to limit the freedom of thought—personal identity, self-expression, free will—that threatens the ideology of the régime of Big Brother and the Party, who have criminalized such concepts into thoughtcrime, as contradictions of Ingsoc orthodoxy. In "The Principles of Newspeak", the appendix to the novel, George Orwell explains that Newspeak usage follows most of the English grammar, yet is a language characterised by a continually diminishing vocabulary; complete thoughts reduced to simple terms of simplistic meaning. Linguistically, the contractions of Newspeak—Ingsoc (English Socialism), Minitrue (Ministry of Truth), etc.—derive from the syllabic abbreviations of Russian, which identify the government and social institutions of the Soviet Union, such as politburo (Politburo of the Central Committee of the Communist Party of the Soviet Union), Comintern (Communist International), kolkhoz (collective farm), and Komsomol (Young Communists' League). The long-term political purpose of the new language is for every member of the Party and society, except the Proles—the working-class of Oceania—to exclusively communicate in Newspeak, by A.D. 2050; during that 66-year transition, the usage of Oldspeak (Standard English) shall remain interspersed among Newspeak conversations. Newspeak is also a constructed language, of planned phonology, grammar, and vocabulary, like Basic English, which Orwell promoted (1942–44) during the Second World War (1939–45), and later rejected in the essay "Politics and the English Language" (1946), wherein he criticizes the bad usage of English in his day: dying metaphors, pretentious diction, and high-flown rhetoric, which produce the meaningless words of doublespeak, the product of unclear reasoning. Orwell's conclusion thematically reiterates linguistic decline: "I said earlier that the decadence of our language is probably curable. Those who deny this may argue that language merely reflects existing social conditions, and that we cannot influence its development, by any direct tinkering with words or constructions."
  • 5.4K
  • 08 Nov 2022
Topic Review
African Civet
The African Civet (Civettictis civetta) is a nocturnal mammal native to sub-Saharan Africa, recognized for its distinctive appearance and unique musk-producing glands. Characterized by its elongated body, short legs, and black-and-white spotted fur, the African Civet inhabits a variety of habitats including forests, savannas, and grasslands. As an omnivorous scavenger, it plays a vital ecological role in maintaining ecosystem balance by feeding on a diverse range of prey, including insects, small mammals, fruits, and carrion.
  • 5.4K
  • 28 Feb 2024
Topic Review
Electrochemical Energy Storage/Conversion System
Electrochemical energy storage and conversion systems such as electrochemical capacitors, batteries and fuel cells are considered as the most important technologies proposing environmentally friendly and sustainable solutions to address rapidly growing global energy demands and environmental concerns. Their commercial applications individually or in combination of two or more devices are based on their distinguishing properties e.g., energy/power densities, cyclability and efficiencies.
  • 5.4K
  • 03 Dec 2020
Topic Review
SCMaglev
The SCMaglev (superconducting maglev, formerly called the MLU) is a magnetic levitation (maglev) railway system developed by Central Japan Railway Company (JR Central) and the Railway Technical Research Institute. On 21 April 2015, a manned seven-car L0 Series SCMaglev train reached a speed of 603 km/h (375 mph), less than a week after the same train clocked 590 km/h (370 mph), breaking the previous land speed record for rail vehicles of 581 km/h (361 mph) set by a JR Central MLX01 maglev train in December 2003.
  • 5.4K
  • 20 Oct 2022
Topic Review
Functionalization of Cyclodextrins
Cyclodextrins (CDs) are cyclic oligosaccharides bearing several glucopyranose residues connected by α-1,4 glycosidic bonds. Natural cyclodextrins contain six, seven, or eight glucopyranose units (α-, β- and γ-cyclodextrin, respectively) and are natural products, biodegradable, and generally lacking in toxicity. Cyclodextrins have toroidal shapes, with the smaller opening of the toroid (primary rim) corresponding to the C6-OH primary hydroxyls and the larger opening (secondary rim) to the C2-OH and C3-OH secondary hydroxyls. 
  • 5.4K
  • 17 Oct 2023
Topic Review
Purple Economy
The purple economy is that part of the economy which contributes to sustainable development by promoting the cultural potential of goods and services. “The purple economy refers to taking account of cultural aspects in economics. It designates an economy that adapts to the human diversity in globalization and that relies on the cultural dimension to give value to goods and services.”
  • 5.4K
  • 18 Oct 2022
Topic Review
Spiking Neural Networks
Spiking neural networks (SNNs) are artificial neural network models that more closely mimic natural neural networks. In addition to neuronal and synaptic state, SNNs also incorporate the concept of time into their operating model. The idea is that neurons in the SNN do not fire at each propagation cycle (as it happens with typical multi-layer perceptron networks), but rather fire only when a membrane potential – an intrinsic quality of the neuron related to its membrane electrical charge – reaches a specific value. When a neuron fires, it generates a signal which travels to other neurons which, in turn, increase or decrease their potentials in accordance with this signal (ref).
  • 5.4K
  • 13 Oct 2021
Topic Review
Non-Enzymatic Antioxidants
Oxidative stress has long been considered one of the pathophysiological mechanisms involved in numerous diseases, which has led to the investigation of the antioxidant systems as a promising therapy more than two decades ago. A useful antioxidant must meet specific characteristics; it must be capable of interacting with biologically relevant oxidants and free radicals; its reaction by-products should be harmless; and finally, it must reach a sufficiently high concentration in the tissue and cell compartments to ensure its activity is quantitatively relevant.
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  • 24 May 2022
Topic Review
Towards A Comprehensive Model of Placemaking Strategy
The title deals with one of the most important issues of the current era after the fragmentation that occurred in urban design and the emergence of many dead places devoid of human presence. Its importance comes in forming a base, a checklist for the development of one of the most important components of the city, (the street), especially the commercial streets, which provide two functions at the same time. A street for movement, linking the city and meeting people's daily needs. Placemaking is an essential and promising step in creating a livable environment. The title deals with a systematic process for converting the vocabulary of previous studies into standards. The theoretical base is comprehensive for all the details of the commercial street. And by reviewing the literature, an integrated set of placemaking steps was identified as a basis for evaluating the commercial street. Accordingly, a theoretical list of dimensions was formed, and then a practical framework for placemaking strategies to form the basis for measuring livability in the commercial street. The higher the level of applying the steps of placemaking, the more livability the street. This is a summary of what the title says
  • 5.4K
  • 24 Feb 2023
Topic Review
Possessions of Muhammad
The possessions of the Islamic prophet Muhammad are a group of his items and possessions such as weapons, animals and others known with unique names. There is doubt about the attribution of these possessions to Muhammad, as many of them were lost during wars and tribulations. The scholar Ahmed Taymour says - after listing the remnants attributed to Muhammad in Constantinople (later Istanbul): "It is no secret that some of these remnants are likely to be true. However, we did not see any of the trustworthy people who mentioned it with proof or denial, for Allah (God), Glory be to Him, who knows about it best, and some of them cannot conceal what the idea or notion that stumbles on of suspicion and disputes it in doubts." The emir Ahmad Ibn Tulun mentioned in his book “Mufākahat al-Khullān fī Hawādith Az-Zamān”, in the incidents of the year 19 AH (640 CE) and 900 AH (1500 CE) that some claimed that they had a mug and some crutches of Muhammad and that “it was found that they are not of the possessions of the Prophet Muhammad, but rather they are the fragments of Al-Layth ibn Sa'd." The scholar Al-Suyuti said, on the authority of Muhammad (his garment): "This (the possessions) was used by the caliphs to inherit it and put it on their shoulders in processions sitting and riding, and it was on the able-bodied when he was killed and contaminated with blood, and I think it was lost in the temptation of the Tatars, for we belong to Allah (God) and to Him we shall return."
  • 5.4K
  • 11 Nov 2022
Topic Review Peer Reviewed
Stefan Uroš II Milutin Nemanjić (1282–1321)
King Stefan Uroš II Milutin Nemanjić (1282—Donje Nerodimlje, October 29, 1321) was a Serbian medieval king, the seventh ruler of the Serbian Nemanide dynasty, the son of King Stefan Uroš I (r. 1243–1276) and Queen Helen Nemanjić (see), the brother of the King Stefan Dragutin (r. 1276–1282) and the father of King Stefan Dečanski (r. 1322–1331). Together with his great grandfather Stefan Nemanja, the founder of the Nemanide dynasty, and his grandson, Emperor Stefan Uroš IV Dušan, King Milutin is considered the most powerful ruler of the Nemanide dynasty. The long and successful military breach of King Milutin, down the Vardar River Valley and deep into the Byzantine territories, represents the beginning of Serbian expansion into southeastern Europe, making it the dominant political power in the Balkan region in the 14th century. During that period, Serbian economic power grew rapidly, mostly because of the development of trading and mining. King Milutin founded Novo Brdo, an internationally important silver mining site. He started minting his own money, producing imitations of Venetian coins (grosso), which gradually diminished in value. This led to the ban of these coins by the Republic of Venice and provided King Milutin a place in Dante’s Divina Commedia. King Milutin had a specific philoktesia fervor: He built or renovated over three dozen Serbian Orthodox churches and monasteries not only in Serbia but also in Thessaloniki, Mt. Athos, Constantinople and The Holy Land. Over fifteen of his portraits can be found in the monumental painting ensembles of Serbian medieval monasteries as well as on two icons. 
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  • 13 Apr 2022
Topic Review
Applications of Ant Colony Optimization
Ant-inspired metaheuristic algorithms known as ant colony optimization (ACO) offer an approach that has the ability to solve complex problems in both discrete and continuous domains. ACOs have gained significant attention in the field of water resources management, since many problems in this domain are non-linear, complex, challenging and also demand reliable solutions. 
  • 5.4K
  • 10 May 2023
Topic Review
Yeasts in Cocoa Bean Fermentation
During the fermentation of cocoa beans, the yeasts produce volatile organic compounds (VOCs). Through reactions associated with amino acid metabolism, yeasts generate important aroma precursors as acetate esters and fatty acid ethyl esters; these are essential in developing fruity flavors and aromas in the final product (usually chocolate). In addition, some yeasts may have pectinolytic and antifungal activity, which is desirable in the post-harvest process of cocoa. The main yeast species in cocoa fermentation are Saccharomyces cerevisiae, Pichia kudriavzevii, and Hanseniaspora opuntiae. These produce higher alcohols and acetyl-CoA to make acetate–esters, compounds that produce floral and fruity notes.
  • 5.4K
  • 19 Jul 2022
Topic Review
Covalent Adaptable Networks
Thermosets are known to be very reliable polymeric materials for high-performance and light-weight applications, due to their retained dimensional stability, chemical inertia and rigidity over a broad range of temperatures. However, once fully cured, they cannot be easily reshaped or reprocessed, thus leaving still unsolved the issues of recycling and the lack of technological flexibility. Vitrimers, introduced by Leibler et al. in 2011, are a valiant step in the direction of bridging the chasm between thermoplastics and thermosets. Owing to their dynamic covalent networks, they can retain mechanical stability and solvent resistance, but can also flow on demand upon heating. More generally, the family of Covalent Adaptable Networks (CANs) is gleaming with astounding potential, thanks to the huge variety of chemistries that may enable bond exchange. Arising from this signature feature, intriguing properties such as self-healing, recyclability and weldability may expand the horizons for thermosets in terms of improved life-span, sustainability and overall enhanced functionality and versatility. In this review, we present a comprehensive overview of the most promising studies featuring CANs and vitrimers specifically, with particular regard for their industrial applications. Investigations into composites and sustainable vitrimers from epoxy-based and elastomeric networks are covered in detail.
  • 5.4K
  • 26 Oct 2020
Topic Review
List of Aircraft (D)
This is a list of aircraft in alphabetical order beginning with 'D'.
  • 5.4K
  • 27 Oct 2022
Topic Review
Sulfur Mustard
Sulfur mustard, commonly known as mustard gas, is the prototypical substance of the sulfur-based family of cytotoxic and vesicant chemical warfare agents known as the sulfur mustards, which can form large blisters on exposed skin and in the lungs. They have a long history of use as a blister-agent in warfare and along with organoarsenic compounds are the most well-studied such agents. Related chemical compounds with similar chemical structure and similar properties form a class of compounds known collectively as sulfur mustards or mustard agents. Pure sulfur mustards are colorless, viscous liquids at room temperature. When used in impure form, such as warfare agents, they are usually yellow-brown and have an odor resembling mustard plants, garlic, or horseradish, hence the name. The common name of "mustard gas" is considered inaccurate because the sulfur mustard is not actually vaporized, but dispersed as a fine mist of liquid droplets. Sulfur mustard was originally assigned the name LOST, after the scientists Wilhelm Lommel and Wilhelm Steinkopf, who developed a method of large-scale production for the Imperial German Army in 1916. Mustard agents are regulated under the 1993 Chemical Weapons Convention. Three classes of chemicals are monitored under this Convention, with sulfur and nitrogen mustard grouped in Schedule 1, as substances with no use other than in chemical warfare. Mustard agents could be deployed by means of artillery shells, aerial bombs, rockets, or by spraying from warplanes or other aircraft. Sulfur mustard can be readily decontaminated through reaction with chloramine-T.
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  • 11 Nov 2022
Topic Review
Zwitterionics Surfactants
Zwitterions are molecules that contain both a positive and negative charge within the same molecule. They are electrically neutral as a whole, but have distinct positive and negative regions within the molecule. The most common example of a zwitterion is the amino acid molecule, which contains both a carboxyl group (-COOH) and an amino group (-NH2) within the same molecule. The carboxyl group is negatively charged at physiological pH, while the amino group is positively charged, resulting in a net charge of zero for the molecule as a whole. Zwitterions have unique properties that make them useful in various applications. They are often used as buffer solutions in biochemistry and molecular biology, as they can maintain a stable pH even when small amounts of acid or base are added. Zwitterions are also used as surfactants, due to their amphipathic nature (i.e. they have both hydrophilic and hydrophobic regions). They are used in applications such as detergents and fabric softeners, where they can help to reduce surface tension and improve the wetting and dispersibility of the product. Zwitterionic surfactants have a unique structure that allows them to interact with a wide range of substances, making them useful in various applications. The unique combination of positive and negative charges in the same molecule provides a balance that enables them to interact with both hydrophilic and hydrophobic substances, allowing them to solubilize oils and greases, emulsify water-insoluble substances, and reduce surface tension.
  • 5.4K
  • 24 Mar 2023
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