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Topic Review
Crime
Crime is a multifaceted and complex concept that generally refers to an act or the commission of an act that is forbidden or the omission of a duty that is commanded by a public law and that makes the offender liable to punishment by that law. It is essentially a breach of societal norms and regulations that are established to maintain order, protect individuals and property, and uphold the general well-being of a community.
  • 1.3K
  • 25 Jan 2024
Topic Review
Mechanosensitive Ion Channels
Mechanosensitive ion channels mediate the neuronal sensation of mechanical signals such as sound, touch, and pain.
  • 1.3K
  • 21 Oct 2021
Topic Review
Biological Effects of Non-Ionising UVR and Ionising Radiation
Non-ionising ultraviolet radiation (UVR) and ionising radiation differ in their interactions with biomolecules, resulting in varied consequences. Here describing the underlying molecular interactions of radiation in the context of biological systems and their outcomes from exposure. 
  • 1.3K
  • 24 Nov 2021
Topic Review
Channelling
Channelling is the process that constrains the path of a charged particle in a crystalline solid. Many physical phenomena can occur when a charged particle is incident upon a solid target, e.g., elastic scattering, inelastic energy-loss processes, secondary-electron emission, electromagnetic radiation, nuclear reactions, etc. All of these processes have cross sections which depend on the impact parameters involved in collisions with individual target atoms. When the target material is homogeneous and isotropic, the impact-parameter distribution is independent of the orientation of the momentum of the particle and interaction processes are also orientation-independent. When the target material is monocrystalline, the yields of physical processes are very strongly dependent on the orientation of the momentum of the particle relative to the crystalline axes or planes. Or in other words, the stopping power of the particle is much lower in certain directions than others. This effect is commonly called the "channelling" effect. It is related to other orientation-dependent effects, such as particle diffraction. These relationships will be discussed in detail later.
  • 1.3K
  • 29 Nov 2022
Topic Review
Ependymal Dysfunctions in the Pathogenesis of Neurodegenerative Diseases
The neuron loss caused by the progressive damage to the nervous system is proposed to be the main pathogenesis of neurodegenerative diseases. Ependyma is a layer of ciliated ependymal cells that participates in the formation of the brain-cerebrospinal fluid barrier (BCB). However, as the protective barrier lining the brain ventricles, the ependyma is extremely vulnerable to cytotoxic and cytolytic immune responses. When the ependyma is damaged, the integrity of BCB is destroyed, and the cerebrospinal fluid (CSF)flow and material exchange is affected, leading to brain microenvironment imbalance, which plays a vital role in the pathogenesis of neurodegenerative diseases.
  • 1.3K
  • 06 May 2023
Topic Review
Bioactive Metabolites from Terrestrial and Marine Actinomycetes
Actinomycetes inhabit both terrestrial and marine ecosystems and are highly proficient in producing a wide range of natural products with diverse biological functions, including antitumor, immunosuppressive, antimicrobial, and antiviral activities.
  • 1.3K
  • 22 Aug 2023
Topic Review
Brain Natriuretic Peptide
Brain natriuretic peptide (BNP), also known as B-type natriuretic peptide, is a hormone secreted by cardiomyocytes in the heart ventricles in response to stretching caused by increased ventricular blood volume. BNP is named as such because it was originally identified in extracts of pig brain. The 32-amino acid polypeptide BNP is secreted attached to a 76–amino acid N-terminal fragment in the prohormone called NT-proBNP (BNPT), which is biologically inactive. Once released, BNP binds to and activates the atrial natriuretic factor receptor NPRA, and to a lesser extent NPRB, in a fashion similar to atrial natriuretic peptide (ANP) but with 10-fold lower affinity. The biological half-life of BNP, however, is twice as long as that of ANP, and that of NT-proBNP is even longer, making these peptides better targets than ANP for diagnostic blood testing. The physiologic actions of BNP are similar to those of ANP and include decrease in systemic vascular resistance and central venous pressure as well as an increase in natriuresis. The net effect of these peptides is a decrease in blood pressure due to the decrease in systemic vascular resistance and, thus, afterload. Additionally, the actions of both BNP and ANP result in a decrease in cardiac output due to an overall decrease in central venous pressure and preload as a result of the reduction in blood volume that follows natriuresis and diuresis.
  • 1.3K
  • 28 Oct 2022
Topic Review
Nano-Sized Titania Particles as Additives in Automotive Lubricants
This study focuses on the wear effects of nano-sized titania as a potential engine lubricant additive. Titanium dioxide nanoparticles have promising wear-reducing properties and significant tribological potential. Titania nanoparticles were homogenized in Group III automotive oil at five different concentrations (0.1; 0.2...0.5 wt%). The nanodoped oil samples were tested on a linear oscillating tribometer with oil circulation. Based on the tribological results, titania nanoparticles increased friction by 20–32% but can reduce the wear area by up to 32%. According to the confocal microscopic examination, wear volume can be reduced by up to 57% with titania nanoparticles. Titania nanoparticles improved the repeatability of tribological measurements. A scanning electron microscopy examination of the wear track revealed that the characteristic wear of the tribological system was abrasive, but a significant amount of adhesive wear was also observed. Energy dispersive X-ray spectroscopy analysis found that the nanoparticles fill the deeper trenches of the wear. The worn surface uniformly contains TiO2 particles and the quantified normalized titanium concentration was between 0.56 and 0.62%.
  • 1.3K
  • 16 Oct 2023
Topic Review
Cardioprotective Effects of Metformin on Myocardial Ischemia/Reperfusion
The most common is coronary artery disease, which causes the death of cardiomyocytes, the cells responsible for cardiac contractility, through ischemia and subsequent reperfusion, which leads to heart failure in the medium and short term. Metformin is one of the most-used drugs for the control of diabetes, which has shown effects beyond the control of hyperglycemia. Some of these effects are mediated by the regulation of cellular energy metabolism, inhibiting apoptosis, reduction of cell death through regulation of autophagy and reduction of mitochondrial dysfunction with further reduction of oxidative stress. This suggests that metformin may attenuate left ventricular dysfunction induced by myocardial ischemia; preclinical and clinical trials have shown promising results, particularly in the setting of acute myocardial infarction. 
  • 1.3K
  • 18 Aug 2023
Topic Review
Management Strategies for COVID-19
The emergence of a novel human coronavirus (SARS-CoV-2) causing severe contagious respiratory tract infections presents a serious threat to public health worldwide. Moreover, no specific antiviral agents are available against this disease known as COVID-19. Therefore, scientific, economic and social measurements are urgently needed for an effective pandemic containment. In the present work, we reviewed recent findings from literature about COVID-19 prophylaxis and management, which could provide a clear view and help readers to be aware of the current pandemic situation.
  • 1.3K
  • 27 Oct 2020
Topic Review
Toll-like Receptors in Cancers
Toll-like receptors (TLRs) represent a family of pattern recognition receptors that recognize certain pathogen-associated molecular patterns and damage-associated molecular patterns. TLRs are highly interesting to researchers including immunologists because of the involvement in various diseases including cancers, allergies, autoimmunity, infections, and inflammation. After ligand engagement, TLRs trigger multiple signaling pathways involving nuclear factor-κB (NF-κB), interferon-regulatory factors (IRFs), and mitogen-activated protein kinases (MAPKs) for the production of various cytokines that play an important role in diseases like cancer. TLR activation in immune as well as cancer cells may prevent the formation and growth of a tumor. Nonetheless, under certain conditions, either hyperactivation or hypoactivation of TLRs supports the survival and metastasis of a tumor. Therefore, the design of TLR-targeting agonists as well as antagonists is a promising immunotherapeutic approach to cancer.
  • 1.3K
  • 26 Jun 2021
Topic Review
NKG2D Natural Killer Cell Receptor
The functionality of NK cells is preserved by the set of activating and inhibitory receptors. Under normal conditions, the appropriate level of major histocompatibility complex (MHC) class I molecules is supervised by inhibitory receptors, which keep NK cells silenced. The “missing self” mechanism considers reduced levels of MHC I (Ia and Ib) molecules when NK cells become activated.
  • 1.3K
  • 02 Jul 2021
Topic Review
3D Live Cell Imaging Challenges
Relevant samples are described and various problems and challenges—including 3D Challenges of 3D imaging by optical sectioning, light scattering and phototoxicity—are addressed. Furthermore, enhanced methods of wide-field or laser scanning microscopy together with some relevant examples and applications are summarized. In the future one may profit from a continuous increase in microscopic resolution, but also from molecular sensing techniques in the nanometer range using e.g., non-radiative energy transfer (FRET).
  • 1.3K
  • 23 Aug 2021
Topic Review
Sustainable Entrepreneurial and Social Networking
Some entrepreneurs are taking the concept of entrepreneurship as a process of introducing good quality new products and services to customers for fulfilling their needs and requirements. However, the concept has transformed to green entrepreneurship and has been associated deeply with the green economy. The businesses are also changing with the changing global environment and are concentrating more towards sustainability and ecological issues. The drastic digitalization has resulted in many changes regarding green entrepreneurship, the social media has been recognized as the most significant source of exchanging information. The social networking sites has become a key source of leveraging current and viable information. Especially, social networking sites and channels are more influential and useful in providing quick and reliable information during the crisis and disasters. The establishment of social media channels and social networking sites as an effect media has also resulted in a great focus on environmental issues, as well as assurance of a better-quality environment through creating awareness among people.
  • 1.3K
  • 17 Aug 2021
Topic Review
Sustainable Transport in Poland
Road transport is one of the key elements of economic development that helps build social and territorial cohesion. The economic development that has taken place in Poland over the last three decades has led to an improvement in road infrastructure throughout the country. Construction of new roads and improvement of existing ones promotes economic development. However, as the number of cars increases, so does the level of air emissions. In reducing pollutant emissions, the analysis of the technological possibilities used and the improvement of their efficiency with the simultaneous minimization of generated pollution is also of particular importance. The purpose of the publication is to present development trends in road transport in Poland and the possibility of reducing emissions in this respect. The method of analysing strategic documents and statistical data was used to achieve this goal. Moreover, the article shows perspectives for reducing the level of emissions from road transport and refers to the assumptions related to the modernization of the transport sector and reducing its share in carbon emissions and its sustainable development in cities.
  • 1.3K
  • 23 Sep 2021
Topic Review
Ambient Mass Spectrometry Imaging and Its Applications
Ambient mass spectrometry imaging (AMSI) has attracted much attention in recent years. As a kind of unlabeled molecular imaging technique, AMSI can enable in situ visualization of a large number of compounds in biological tissue sections in ambient conditions. In this review, the developments of various AMSI techniques are discussed according to one-step and two-step ionization strategies. In addition, recent applications of AMSI for lipid and metabolite analysis (from 2016 to 2021) in disease diagnosis, animal model research, plant science, drug metabolism and toxicology research, etc., are summarized. Finally, further perspectives of AMSI in spatial resolution, sensitivity, quantitative ability, convenience and software development are proposed. 
  • 1.3K
  • 29 Mar 2022
Topic Review
A Focus on Active Chemicals in Sub-Saharan Africa
Active chemicals are among the contaminants of emerging concern that are rarely covered in regulatory documents in sub-Saharan Africa. 
  • 1.3K
  • 31 Dec 2021
Topic Review
Potential Nutraceuticals in Alzheimer’s Disease
Alzheimer’s disease (AD) incidence is increasing worldwide at an alarming rate. Considering this increase, prevention efforts, stemming from scientific research, health education, and public policies, are critical. Clinical studies evidenced that healthy lifestyles along with natural multitarget and disease-modifying agents have a preventative impact on AD or mitigate symptoms in diagnosed patients.
  • 1.3K
  • 29 Mar 2022
Topic Review
Dysregulation of the Gut Barrier Function during ALD
Chronic alcohol consumption and alcohol-associated liver disease (ALD) represent a major public health problem worldwide. Only a minority of patients with an alcohol-use disorder (AUD) develop severe forms of liver disease (e.g., steatohepatitis and fibrosis) and finally progress to the more advanced stages of ALD, such as severe alcohol-associated hepatitis and decompensated cirrhosis. Emerging evidence suggests that gut barrier dysfunction is multifactorial, implicating microbiota changes, alterations in the intestinal epithelium, and immune dysfunction. This failing gut barrier ultimately allows microbial antigens, microbes, and metabolites to translocate to the liver and into systemic circulation. Subsequent activation of immune and inflammatory responses contributes to liver disease progression.
  • 1.3K
  • 09 Mar 2022
Topic Review
Microbial Metal Removing Strategy
Rapid industrialization has led to the pollution of soil and water by various types of contaminants. Heavy metals (HMs) are considered the most reactive toxic contaminants, even at low concentrations, which cause health problems through accumulation in the food chain and water. Remediation using conventional methods, including physical and chemical techniques, is a costly treatment process and generates toxic by-products, which may negatively affect the surrounding environment. Therefore, biosorption has attracted significant research interest in the recent decades. In contrast to existing methods, bacterial biomass offers a potential alternative for recovering toxic/persistent HMs from the environment through different mechanisms for metal ion uptake.
  • 1.3K
  • 23 Mar 2022
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