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Topic Review
Resilient and Sustainable Group Decision
Group decision-making should contribute to resilience and sustainability and, particularly, the achievement of the objectives in view of future risks. Further, transparency in and participation in the decision process are needed to limit problems in the implementation phase of the decision. The literature survey here presented suggests some of the key attributes for supporting sustainable and resilient group decisions. To this aim, a focused systematic review was conducted to study the existing group decision-making methods in the literature and how the concepts of sustainability and resilience have been employed.
  • 1.3K
  • 13 Nov 2020
Topic Review
Iron Dysregulation in Human Cancer
Iron (Fe) is a trace element that plays essential roles in various biological processes such as DNA synthesis and repair, as well as cellular energy production and oxygen transport, and it is currently widely recognized that iron homeostasis is dysregulated in many cancers. Indeed, several iron homeostasis proteins may be responsible for malignant tumor initiation, proliferation, and for the metastatic spread of tumors. A large number of studies demonstrated the potential clinical value of utilizing these deregulated proteins as prognostic and/or predictive biomarkers of malignancy and/or response to anticancer treatments. Additionally, the iron present in cancer cells and the importance of iron in ferroptosis cell death signaling pathways prompted the development of therapeutic strategies against advanced stage or resistant cancers.
  • 1.3K
  • 05 Jan 2021
Topic Review
Cucurbits
Cucurbit viruses cause considerable economic losses worldwide. The most common viral diseases affecting this crop family are Potyviruses, Cucumoviruses, Criniviruses, Ipomoviruses, Tobamoviruses, and the emerging Begomoviruses. Four main cucurbit crops are grown worldwide, namely melon, cucumber (Cucumis), watermelon (Citrullus), and squash (Cucurbita). Huge natural variation is also available within each genus, providing valuable sources of genetic resistance to these diseases. Intraspecific and intrageneric diversity and crossability are key factors to select the optimum breeding strategies. Melon and cucumber are diverse species for which intraspecific resistance is available. Conversely, in Citrullus and Cucurbita, wild relatives provide the resistance diversity absent in watermelon and in C. pepo. Some of the classical sources used by breeders, many of which are multi-resistant, come from corresponding origin centers in Asia, Africa, and America, as well as from secondary centers of diversity. Genetic studies have identified dominant and recessive and often complex resistance. Many of the genes identified have been mapped and markers for MAS are available, but higher mapping resolutions are required to identify the corresponding genes. Only a few genes could be cloned and functionally characterized. Efforts are underway to use genome mapping and functional genomics to advance toward a genomic-assisted breeding against viral diseases in cucurbits.
  • 1.3K
  • 14 Jan 2021
Topic Review
Caffeic Acid Phenethyl Ester
Caffeic acid phenethyl ester (CAPE), is one of the most extensively investigated active components of propolis and it is considered responsible for most of its beneficial effects. Among the others, CAPE exerts protection towards many neurological disorders. This review summarizes the protective effects of CAPE towards oxidative stress, inflammation, apoptosis, neurotoxic substances, neurodegenerative diseases, brain tumors and neuronal injuries as well. A paragrah on derivatives of CAPE is also included.
  • 1.3K
  • 30 Mar 2021
Topic Review
Carbon Dots for Cancer Therapy
Diagnostic approaches and chemotherapeutic delivery based on nanotechnologies, such as nanoparticles (NPs), could be promising candidates for the new era of cancer research. Recently great attention has been received by carbon-based nanomaterials such as Carbon Dots (CDs), due their variegated physical-chemical properties that makes these systems appealing for multiple use from bioimaging, biosensing, nano-carriers for drug delivery systems to innovative therapeutic agents in photodynamic (PDT) and photothermal therapy (PTT). Numerous researchers evaluated the possible use of CDs as targeted anticancer drug delivery, photodynamic therapy, photothermal therapy, as well as gene delivery for cancer theranostic.
  • 1.3K
  • 23 Jun 2021
Topic Review
Microphthalmia-Associated Transcription Factor
Microphthalmia-associated transcription factor (MITF) is a central player of melanocyte survival, function and development. It belongs to the MiT/TFE family of transcription factors in vertebrates, consisting of four distinct but closely related and evolutionary conserved members, including MITF, transcription factor EB (TFEB), TFE3 and TFEC. Structurally, MITF encodes a basic–helix–loop–helix leucine zipper (bHLH-ZIP) transcription factor, thereby exerting its function by regulating genes involved in cell cycle progression and differentiation, a role sustained throughout the process of melanogenesis and in melanoma.
  • 1.3K
  • 13 Aug 2021
Topic Review
Thundercloud Features in Different Regions
A comparison of thundercloud characteristics in different regions of the world was conducted. The clouds studied developed in India, China and in two regions of Russia. Several field projects were discussed. Cloud characteristics were measured by weather radars, the SEVERI instrument installed on board of the Meteosat satellite, and lightning detection systems. The statistical characteristics of the clouds were tabulated from radar scans and correlated with lightning observations. Thunderclouds in India differ significantly from those observed in other regions. The relationships among lightning strike frequency, supercooled cloud volume, and precipitation intensity were analyzed. In most cases, high correlation was observed between lightning strike frequency and supercooled volume. 
  • 1.3K
  • 23 Aug 2021
Topic Review
Escherichiacoli Nissle 1917
Escherichia coli Nissle 1917 (EcN) is a commonly used probiotic in clinical practice. Its facultative anaerobic property drives it to selectively colonize in the hypoxic area of the tumor for survival and reproduction. EcN can be engineered as a bacteria-based microrobot for molecular imaging, drug delivery, and gene delivery.
  • 1.3K
  • 27 Aug 2021
Topic Review
New Generation Metaheuristic Algorithms
Metaheuristics are the special branch of heuristic methods that can explore a whole problem space with different heuristic approaches by a replicated intelligent iterative process. Normally, metaheuristics stimulate the natural evolution strategy to produce convergence, which needs less parameters to tune for any certain problem. This is why metaheuristic has been implemented to large instance NP-hard problems, which leads to a similar optimization like the exact methods.
  • 1.3K
  • 05 Nov 2021
Topic Review
Antimicrobial Activity of Gemini Surfactants
Gemini cationic surfactants (GS) are constructed from two alkylammonium monomeric salts linked by a spacer.They exhibit significant surface, aggregation and antimicrobial properties. Due to the fact that, in order to achieve the desired utility effect, the minimal concentration of compounds are used, they are in line with the principle of greenolution (green evolution) in chemistry. The obtained results indicate that the synthesized compounds are effective microbicides with a broad spectrum of biocidal activity and are active against Escherichia coli, Staphylococcus aureus, yeast Candida albicans, molds Aspergillus niger and Penicillium chrysogenum. These compounds constitute a new, interesting class of microbicides with a broad spectrum of biocidal activity.
  • 1.3K
  • 28 Jan 2022
Topic Review
Deep Learning-Based Building Extraction from Remote Sensing Images
Building extraction from remote sensing (RS) images is a fundamental task for geospatial applications, aiming to obtain morphology, location, and other information about buildings from RS images, which is significant for geographic monitoring and construction of human activity areas. In recent years, deep learning (DL) technology has made remarkable progress and breakthroughs in the field of RS and also become a central and state-of-the-art method for building extraction. 
  • 1.3K
  • 15 Dec 2021
Topic Review
Small Nucleolar Derived RNAs as Regulators of Cancer
RNA fragments derived from full-length small nucleolar RNAs (snoRNAs) have been shown to be specifically excised and functional. These sno-derived RNAs (sdRNAs) have been implicated as gene regulators in a multitude of cancers, controlling a variety of genes post-transcriptionally via association with the RNA-induced silencing complex (RISC).
  • 1.3K
  • 31 Aug 2022
Topic Review
2D Filters
Two dimensional filters have seen substantial development effort due to their importance and high applicability across several domains. In the 2-D case the situation is quite different from the 1-D case, because the multi-dimensional polynomials cannot in general be factored. This means that an arbitrary transfer function cannot generally be manipulated into a form required by a particular implementation. The input-output relationship of a 2-D IIR filter obeys a constant-coefficient linear partial difference equation from which the value of an output sample can be computed using the input samples and previously computed output samples. Because the values of the output samples are fed back, the 2-D filter, like its 1-D counterpart, can be unstable.
  • 1.3K
  • 26 Oct 2022
Topic Review
Active Tourism for People with Disabilities
Active tourism improves human health and well-being regardless of age or disabilities.Tourism is a form of physical and social activity performed outdoors. Tourism requires mobility and therefore supports physical activity. Movement improves human health regardless of the age or potential disabilities of individuals.
  • 1.3K
  • 07 Nov 2022
Topic Review
Game Programming
Game programming, a subset of game development, is the software development of video games. Game programming requires substantial skill in software engineering and computer programming in a given language, as well as specialization in one or more of the following areas: simulation, computer graphics, artificial intelligence, physics, audio programming, and input. For massively multiplayer online games(MMOG), knowledge of additional areas such as network programming and database programming is requisite. Though often engaged in by professional game programmers, some may program games as a hobby.
  • 1.3K
  • 10 Nov 2022
Topic Review
Deep Learning Applications in Tumor Pathology
The revolution of artificial intelligence and its impacts on our daily life has led to tremendous interest in the field and its related subtypes: machine learning and deep learning. Scientists and developers have designed machine learning- and deep learning-based algorithms to perform various tasks related to tumor pathologies, such as tumor detection, classification, grading with variant stages, diagnostic forecasting, recognition of pathological attributes, pathogenesis, and genomic mutations. Pathologists are interested in artificial intelligence to improve the diagnosis precision impartiality and to minimize the workload combined with the time consumed, which affects the accuracy of the decision taken.
  • 1.3K
  • 15 Nov 2022
Topic Review
Vat Purnima
Vat Purnima or pournima chavan or Wat Purnima (वट पूर्णिमा, vaṭapūrṇimā, also called Vat Savitri is a celebration observed by married women in the Western Indian states of Gujarat, Maharashtra, Goa and some regions of eastern Uttar Pradesh. On this Purnima or "full moon" during the three days of the month of Jyeshtha in the Hindu calendar (which falls in May-June in the Gregorian calendar) a married woman marks her love for her husband by tying a ceremonial thread around a banyan tree. The celebration is based on the legend of Savitri and Satyavan as narrated in the epic Mahabharata.
  • 1.3K
  • 15 Nov 2022
Topic Review
Aflatoxin Contamination of Agricultural Products and Foods in Pakistan
Aflatoxins (AFs) are the most important, toxic, mutagenic, and carcinogenic fungal toxins that routinely contaminate food and feed.  In Pakistan, agriculture contributes approximately 21.8% to the GDP (gross domestic product), a substantial portion of the country’s overall economy. More than 65–70% of the population in Pakistan depends on agriculture for its livelihood. The warm, humid environmental conditions of Pakistan are very favorable for the invasion of environmental fungi such as Aspergillus, which can produce AFs as secondary metabolites. High humidity and insufficient ventilation in agricultural commodity storage areas are also problems in Pakistan and are key contributors to Aspergillus growth and the production of AFs in foods and feeds. Pakistani crops are, therefore, prone to contamination by AFs, with improper agronomic and storage practices by farmers and processors exacerbating the problem.
  • 1.3K
  • 09 Dec 2022
Topic Review
Eating Disorders in Women with Polycystic Ovary Syndrome
Polycystic ovary syndrome (PCOS) is a heterogeneous, multifactorial disease that leads to menstrual and ovulatory irregularities, infertility, hyperandrogenism, and metabolic disturbances. It is recognized as the most prevalent endocrine/metabolic disorder in reproductive-aged women. Despite continuous research efforts, the unifying pathophysiological mechanisms that could explain the etiology of this complex disorder are still not fully understood. The interplay between genetic and epigenetic factors, mitochondrial dysfunction, altered protein and miRNA profiles, and environmental factors that also contribute to obesity lead to exaggerated gonadotropin-releasing hormone (GnRH) pulsatility with hypersecretion of luteinizing hormone (LH) and insulin resistance (IR). Compensatory hyperinsulinemia adds to increased ovarian androgen production and impaired oocyte development. The essential role of the frequent coexistence of mental disorders and polycystic ovary syndrome (PCOS) is being increasingly recognized in the management of PCOS patients since it influences the success of weight loss interventions. Patients frequently experience disrupted eating behaviors, evidenced by the high prevalence of eating disorders in this population. Therefore, assessment and potential modification of eating disorders and eating-related behavior might be especially relevant to improve obesity treatment outcomes in this population, which remains the most efficient causal treatment in PCOS patients with high metabolic risk. 
  • 1.3K
  • 26 Dec 2022
Topic Review
Health Effects of Isoflavones
Estrogenic isoflavones are essentially considered to be the hydroxylated compounds i.e. genistein, daidzein and glycitein, the methoxylated substances i.e. biochanin A and formononetin as well as the isoflavane metabolite: equol. Their estrogenic effects have been shown in many occasions and many models and they can be either beneficial or adverse depending on the physiological status of the consummers.
  • 1.3K
  • 08 Feb 2023
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