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Topic Review
Machines Additive Manufacturing
Modern-day machine applications require extraordinary performance parameters such as high power-density, integrated functionalities, improved thermal, mechanical & electromagnetic properties. Additive manufacturing (AM)offers a higher degree of design flexibility to achieve these performance parameters, which is impossible to realize through conventional manufacturing techniques.
  • 1.4K
  • 26 Aug 2021
Topic Review
Applications of AMPs in Packaging
Antimicrobial Peptides can be defined as the molecules of the innate immune system present in all life forms, ranging from bacteria to human beings. The innate immune system is a defence system working non-specifically against injury or infection in the barrier surface. AMPs are composed of a sequence of amino acid ranging from 5 to 50 chains, usually L-amino acids.
  • 1.4K
  • 13 Aug 2021
Topic Review
Circadian Rhythms and Glioblastomas
Gliomas are solid tumors of the central nervous system (CNS) that originated from different glial cells. The World Health Organization (WHO) classifies these tumors into four groups (I–IV) with increasing malignancy. Glioblastoma (GBM) is the most common and aggressive type of brain tumor classified as grade IV. GBMs are resistant to conventional therapies with poor prognosis after diagnosis even when the Stupp protocol that combines surgery and radiochemotherapy is applied. Nowadays, few novel therapeutic strategies have been used to improve GBM treatment, looking for higher efficiency and lower side effects, but with relatively modest results. The circadian timing system temporally organizes the physiology and behavior of most organisms and daily regulates several cellular processes in organs, tissues, and even in individual cells, including tumor cells.
  • 1.4K
  • 15 Aug 2021
Topic Review
Healthy School Canteen Intervention
Implementing a school-based intervention to promote healthier dietary habits in the school environment among Malaysian adolescents using qualitative methods. This qualitative study was conducted in four secondary schools in Perak and Selangor (two urban and two rural schools) that received the intervention (either training or training and food subsidy). A total of eight focus groups (68 students aged 15 years old) and 16 in-depth interviews were conducted with canteen operators, school convenience shop operators, school teachers and school principals in each school. Thematic analysis was used to analyse the qualitative data to identify suitable themes. Finding several initiatives and changes by the schools’ stakeholders to change to a healthy school canteen programme. The stakeholders also noticed the students’ food preferences that influence healthy food intake in canteens and convenience shops. The food vendors and school administrators also found that subsidising healthy meals might encourage healthy eating. Among barriers to implementing healthy school initiatives were the student’s perception of healthy food and their eating habits, which also affect the food vendors’ profit if they want to implement a healthy canteen. The school-based intervention has the potential to promotes healthier eating among school adolescents. Continuous training and monitoring of canteen operators and convenience shops are needed, including building partnerships and educating the students on healthy eating to cultivate healthy eating habits.
  • 1.4K
  • 19 Nov 2021
Topic Review
NiO-TiO2 p-n Heterojunction
NiO is a typical p-type semiconductor and it has widely been combined with TiO2 to form the p-n heterojunction due to its suitable energy band structure, high charge carrier concentration, high chemical stability and low cost. Decreasing the size of NiO to nanoclusters helps to improve the electron transfer channels on the surface of TiO2, thus enhance photocatalytic hydrogen production efficiency.
  • 1.4K
  • 19 Apr 2022
Topic Review
Insulin in the Brain
Insulin action in the brain regulates several processes including energy expenditure, glucose homeostasis, feeding behavior and satiety, reward pathways, reproduction, cell proliferation and differentiation. Moreover, insulin has neuroprotective and neuromodulatory properties and plays a crucial role in neuronal transmission and survival, neurogenesis, plasticity, and memory and cognition.
  • 1.4K
  • 11 Apr 2022
Topic Review
miRNAs in HTLV-1 Induced T Cell Leukemia
Human T cell leukemia virus type 1 (HTLV-1) was identified as the first pathogenic human retrovirus and is estimated to infect 5 to 10 million individuals worldwide. Unlike other retroviruses, there is no effective therapy to prevent the onset of the most alarming diseases caused by HTLV-1, and the more severe cases manifest as the malignant phenotype of adult T cell leukemia (ATL). MicroRNA (miRNA) dysfunction is a common feature of leukemogenesis, and it is no different in ATL cases. 
  • 1.4K
  • 23 May 2022
Topic Review
Node
A node is a point along a standing wave where the wave has minimum amplitude. For instance, in a vibrating guitar string, the ends of the string are nodes. By changing the position of the end node through frets, the guitarist changes the effective length of the vibrating string and thereby the note played. The opposite of a node is an anti-node, a point where the amplitude of the standing wave is at maximum. These occur midway between the nodes.
  • 1.4K
  • 16 Nov 2022
Topic Review
List of Crytocarya Species
This is a list of Cryptocarya species, trees in the Lauraceae family. The list follows Plants of the World Online, which recognised 357 accepted species (As of May 2021).
  • 1.4K
  • 28 Nov 2022
Topic Review
Ethics in the Bible
Ethics in the Bible refers to the system(s) or theory(ies) produced by the study, interpretation, and evaluation of biblical morals, (including the moral code, standards, principles, behaviors, conscience, values, rules of conduct, or beliefs concerned with good and evil and right and wrong), that are found in the Hebrew and Christian Bibles. It comprises a narrow part of the larger fields of Jewish and Christian ethics, which are themselves parts of the larger field of philosophical ethics. Ethics in the Bible is unlike other western ethical theories in that it is seldom overtly philosophical. It presents neither a systematic nor a formal deductive ethical argument. Instead, the Bible provides patterns of moral reasoning that focus on conduct and character in what is sometimes referred to as virtue ethics. This moral reasoning is part of a broad, normative covenantal tradition where duty and virtue are inextricably tied together in a mutually reinforcing manner. The ethics of the Bible have been criticized with some calling it immoral in some of its teachings. Slavery, genocide, supersessionism, the death penalty, violence, patriarchy, sexual intolerance, colonialism, and the problem of evil and a good God, are examples of criticisms of ethics in the Bible. Conversely it has been seen as a cornerstone of both Western culture, and many other cultures across the globe. Concepts such as justice for the widow, orphan and stranger provided inspiration for movements ranging from abolitionism in the 18th and 19th century, the civil rights movement, the Anti-Apartheid Movement, and liberation theology in Latin America.
  • 1.4K
  • 30 Nov 2022
Topic Review
Vincent's Disease
Acute necrotizing ulcerative gingivitis (ANUG) is a common, non-contagious infection of the gums with sudden onset. The main features are painful, bleeding gums, and ulceration of inter-dental papillae (the sections of gum between adjacent teeth). This disease, along with necrotizing (ulcerative) periodontitis (NP or NUP) is classified as a necrotizing periodontal disease, one of the seven general types of gum disease caused by inflammation of the gums (periodontitis). The often severe gum pain that characterizes ANUG distinguishes it from the more common chronic periodontitis which is rarely painful. If ANUG is improperly treated or neglected, it may become chronic and/or recurrent. The causative organisms are mostly anaerobic bacteria, particularly Fusobacteriota and spirochete species. Predisposing factors include poor oral hygiene, smoking, poor nutrition, psychological stress, and a weakened immune system. When the attachments of the teeth to the bone are involved, the term NUP is used. Treatment of ANUG is by removal of dead gum tissue and antibiotics (usually metronidazole) in the acute phase, and improving oral hygiene to prevent recurrence. Although the condition has a rapid onset and is debilitating, it usually resolves quickly and does no serious harm. The informal name trench mouth arose during World War I as many soldiers developed the disease, probably because of the poor conditions and extreme psychological stress.
  • 1.4K
  • 30 Nov 2022
Topic Review
Steroidal (Glyco)Alkaloids: Classification
Steroidal (glycol)alkaloids S(G)As are secondary metabolites made of a nitrogen-containing steroidal skeleton linked to a (poly)saccharide, naturally occurring in the members of the Solanaceae and Liliaceae plant families. The genus Solanum is familiar to all of us as a food source (tomato, potato, eggplant), but a few populations have also made it part of their ethnobotany for their medicinal properties. The recent development of the isolation, purification and analysis techniques have shed light on the structural diversity among the SGAs family, thus attracting scientists to investigate their various pharmacological properties. 
  • 1.4K
  • 11 Jul 2023
Topic Review
DNA-Based Animal Species Authentication in Dairy Products
Milk is one of the most important nutritious foods, widely consumed worldwide, either in its natural form or via dairy products. Currently, several economic, health and ethical issues emphasize the need for a more frequent and rigorous quality control of dairy products and the importance of detecting adulterations in these products. For this reason, several conventional and advanced techniques have been proposed, aiming at detecting and quantifying eventual adulterations, preferentially in a rapid, cost-effective, easy to implement, sensitive and specific way. DNA-based methods relying on polymerase chain reaction (PCR) have been widely applied to detect adulterations in foods from both plant and animal origins, including dairy products because of their simplicity, high sensitivity and high specificity. They benefit from the high thermal stability of DNA molecules, which is particularly relevant when analysing processed foods, and are independent from immunochemical recognition, making them not susceptible to cross-reactivity. The ubiquity of nucleic acids in every type of cell and particularity in healthy mammary glands, which have high numbers of leucocytes and epithelial cells that are transferred to the milk, is another advantage to highlight. During cheese making, these cells are concentrated and allow the isolation of DNA to discriminate the species.
  • 1.4K
  • 28 Apr 2022
Topic Review
Wine Cooperatives in Germany
According to the German cooperative law, cooperatives are defined as “associations of a non-closed number of members whose purpose is to promote their members’ income and business or their social or cultural interests through joint business operations” (GenG §1). In Germany, the following actors can become members of a cooperative: physical persons, commercial partnerships (in German: Personengesellschaften des Handelsrechts), legal entities under private and public law. Cooperatives represent a horizontal cooperation among producers.
  • 1.4K
  • 25 Nov 2021
Topic Review
Liver Metabolism Regulation by Transcriptional Factors and Coactivators
The liver is one of the main organs that contributes to the regulation of blood glucose levels by releasing the glucose into circulation when blood glucose levels are low and stores along skeletal muscles excess of glucose as glycogen in postprandial states. In mammals, the liver is the central organ for fatty acid metabolism and a key player in glucose metabolism. The liver acts as a crossroad, which metabolically connects various organs, especially skeletal muscle, and adipose tissues, in the endeavor to maintain the long-term energy supply to the body. The regulation of liver glucose metabolism and lipid metabolism is tightly controlled by dietary, hormonal, and neural signals through the activation of various transcriptional factors and coactivators.
  • 1.4K
  • 01 Mar 2023
Topic Review
LIN28-let-7-ARID3B Pathway
Placental disorders are a major cause of pregnancy loss in humans, and 40%–60% of embryos are lost between fertilization and birth. Successful embryo implantation and placental development requires rapid proliferation, invasion, and migration of trophoblast cells. In recent years, microRNAs (miRNAs) have emerged as key regulators of molecular pathways involved in trophoblast function. A miRNA binds its target mRNA in the 3ʹ-untranslated region (3ʹ-UTR), causing its degradation or translational repression. Lethal-7 (let-7) miRNAs induce cell differentiation and reduce cell proliferation by targeting proliferation-associated genes. The oncoprotein LIN28 represses the biogenesis of mature let-7 miRNAs. Proliferating cells have high LIN28 and low let-7 miRNAs, whereas differentiating cells have low LIN28 and high let-7 miRNAs. In placenta, low LIN28 and high let-7 miRNAs can lead to reduced proliferation of trophoblast cells, resulting in abnormal placental development. In trophoblast cells, let-7 miRNAs reduce the expression of proliferation factors either directly by binding their mRNA in 3ʹ-UTR or indirectly by targeting the -rich interaction domain (ARID)3B complex, a transcription-activating complex comprised of ARID3A, ARID3B, and histone demethylase 4C (KDM4C). In this review, we discuss regulation of trophoblast function by miRNAs, focusing on the role of LIN28-let-7-ARID3B pathway in placental development.
  • 1.4K
  • 27 Oct 2020
Topic Review
Ventilation System
An additional window frame with a ventilation function is applied to the existing window. Thus, when the window is closed, a cavity, which is created between window frames, serves as an air path for ventilation. The additional frame has the same material and finishing as the existing frame, thereby ensuring design consistency. On the outside, the frame does not show any application of the mechanical system. Another advantage of the proposed system is that, as the width is 65 mm, it occupies as small an area as possible and minimally affects the view from the inside. Polyvinyl chloride (PVC), a generally used material for windows, is used for the ventilation system, and this system is formed in a "U"-shape consistent with the existing window frame. This system can be attached or detached on the existing window frame and does not generate either a gap or a distance in the process of installation for airtightness. The cavity is 45 mm in width, 20 mm in depth, and 1940 mm in height and serves as an air path connected to the outdoor air intake and the indoor air supply outlet.
  • 1.4K
  • 26 Oct 2020
Topic Review
ALSP
Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) is a neurological condition characterized by changes to certain areas of the brain. A hallmark of ALSP is leukoencephalopathy, which is the alteration of a type of brain tissue called white matter. White matter consists of nerve fibers (axons) covered by a substance called myelin that insulates and protects them. The axons extend from nerve cells (neurons) and transmit nerve impulses throughout the body. Areas of damage to this brain tissue (white matter lesions) can be seen with magnetic resonance imaging (MRI). Another feature of ALSP is swellings called spheroids in the axons of the brain, which are a sign of axon damage. Also common in ALSP are abnormally pigmented glial cells. Glial cells are specialized brain cells that protect and maintain neurons. Damage to myelin and neurons is thought to contribute to many of the neurological signs and symptoms in people with ALSP.
  • 1.4K
  • 04 Jan 2021
Topic Review
Mitophagy and the Brain
Mitophagy is a form of macroautophagy, were mitochondria and their contents are ubiquitinated, engulfed, and removed through lysosome degradation.
  • 1.4K
  • 08 Jan 2021
Topic Review
2D Materials in Ultrafast Lasers
Ultrafast lasers are the key component of ultrafast photonics, which have come into practice in various fields, such as micromachining, communication, medical procedures, gas detection, and remote sensing. With the advantages of stability, compactness, and easy implementation, mode-locking and Q-switching are two notable techniques to achieve ultrafast pulsed lasers, where SAs perform crucial roles in many types of ultrafast lasers, such as fiber, solid-state, and waveguide lasers.
  • 1.4K
  • 25 Aug 2021
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