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Topic Review
Food Control Achievements of NIR
Major milestones in the design of near infrared spectrometers as well as their demonstrated efficiency in the mitigation of food security issues with regards to commonly consumed food matrices are herein presented.   
  • 1.4K
  • 18 Mar 2021
Biography
Jack McAuliffe
John R. "Jack" McAuliffe (born 1945) is an American brewer best known as the founder of the New Albion Brewing Company in Sonoma, California. McAuliffe started the brewery, considered the first American microbrewery in the modern era, in 1976.[1][2] (As of 2013), he lives in Arkansas.[3] McAuliffe was born on May 11, 1945 Caracas, Venezuela. His father, John McAuliffe, intercepted and transla
  • 1.4K
  • 29 Dec 2022
Topic Review
Diabetes and Vitamin B6
Vitamin B6 is a cofactor for approximately 150 reactions that regulate the metabolism of glucose, lipids, amino acids, DNA, and neurotransmitters. In addition, it plays the role of antioxidant by counteracting the formation of reactive oxygen species (ROS) and advanced glycation end-products (AGEs). Epidemiological and experimental studies indicated an evident inverse association between vitamin B6 levels and diabetes, as well as a clear protective effect of vitamin B6 on diabetic complications.
  • 1.4K
  • 18 Jul 2022
Topic Review
Qualitative Methods in Translational Health
Translational health research is an interdisciplinary field aimed at bridging the gap between basic science studies, preventative studies, and clinical practice to improve health-related outcomes. Qualitative research methods provide a unique perspective on the emotional, social, cultural, and contextual factors that influence health and healthcare and thus are recognized as valuable tools for translational health research. This approach can be embedded within a mixed method design which complements the quantitative findings.
  • 1.4K
  • 09 Oct 2023
Topic Review
Three Mothers (2006) by Dina Zvi-Riklis
Dina Zvi-Riklis’ film Three Mothers (2006) reveals a complex approach to the issue of immigration, an issue that is central to both the Jewish religion and Israeli identity. While for both, reaching the land of Israel means arriving in the Promised Land, they are quite dissimilar in that one is a religious command while the other is an ideological imperative. But more than anything, the two approaches share a common imperative to forget the past. However, this imperative does not apply to the heroines of Three Mothers, a film which follows the extraordinary trajectory of triplet sisters, born to a rich Jewish family in Alexandria, who were forced to leave Egypt after King Farouk’s abdication and immigrate to Israel. This article demonstrates that Three Mothers represents an outstanding achievement because it dares to deal with its heroines’ longing for the world left behind and the complexity of integrating the past into the present. Following Nicholas Bourriaud’s Radicant theory, designating an organism that grows roots and adds new ones as it advances, this article will prove that though the heroines of Three Mothers never avow their longing for Egypt, the film’s narrative succeeds in revealing a subversive démarche through which the sisters succeed in integrating Egypt into their present.
  • 1.4K
  • 19 Aug 2020
Topic Review
Classification Tools Heart Rate Variability
Chronic stress is the main cause of health problems in high-risk jobs. Wearable sensors can become an ecologically valid method of stress level assessment in real-life applications. We sought to determine a non-invasive technique for objective stress monitoring. Data were collected from firefighters during 24-h shifts using sensor belts equipped with a dry-lead electrocardiograph (ECG) and a three-axial accelerometer. Levels of stress experienced during fire incidents were evaluated via a brief self-assessment questionnaire. Types of physical activity were distinguished basing on accelerometer readings, and heart rate variability (HRV) time series were segmented accordingly into corresponding fragments. Those segments were classified as stress/no-stress conditions. Receiver Operating Characteristic (ROC) analysis showed true positive classification as stress condition for 15% of incidents (while maintaining almost zero False Positive Rate), which parallels the amount of truly stressful incidents reported in the questionnaires. These results show a firm correspondence between the perceived stress level and physiological data. Psychophysiological measurements are reliable indicators of stress even in ecological settings and appear promising for chronic stress monitoring in high-risk jobs, such as firefighting.
  • 1.4K
  • 28 Oct 2020
Topic Review
Chitosan as a Biomaterial
Chitosan remarkable properties have aroused the interest of applying this material in several biomedical applications, such as tissue engineering, wound dressing, drug delivery, and cancer treatment, what has aroused the interest of this review to gather the state-of-the-art concerning this polysaccharide when used as a biomaterial, providing information about its characteristics, chemical modifications, and applications.
  • 1.4K
  • 25 Nov 2020
Topic Review
ADNP Syndrome
ADNP syndrome is a condition that causes a wide variety of signs and symptoms. Its hallmark features are intellectual disability and autism spectrum disorder, which is characterized by impaired communication and social interaction. Affected individuals also have distinctive facial features and abnormalities of multiple body systems.  
  • 1.4K
  • 23 Dec 2020
Topic Review
MOB
The MOB family proteins are constituted by highly conserved eukaryote kinase signal adaptors involved in the regulation of cell cycle progression, cell proliferation versus proliferation, morphogenesis, and cell differentiation and are often essential both for cell and organism survival.
  • 1.4K
  • 19 Jan 2021
Topic Review
IgA Vasculitis and IgA Nephropathy
Many authors suggested that IgA Vasculitis (IgAV) and IgA Nephropathy (IgAN) would be two clinical manifestations of the same disease; in particular, that IgAV would be the systemic form of the IgAN. A limited number of studies have included sufficient children or adults with IgAN or IgAV (with or without nephropathy) and followed long enough to conclude on differences or similarities in terms of clinical, biological or histological presentation, physiopathology, genetics or prognosis. All therapeutic trials available on IgAN excluded patients with vasculitis. IgAV and IgAN could represent different extremities of a continuous spectrum of the same disease. Due to skin rash, patients with IgAV are diagnosed precociously. Conversely, because of the absence of any clinical signs, a renal biopsy is practiced for patients with an IgAN to confirm nephropathy at any time of the evolution of the disease, which could explain the frequent chronic lesions at diagnosis.
  • 1.4K
  • 02 Jun 2021
Topic Review
Circular Food Supply Chains Barriers
The concept of the circular economy (CE) has gained importance worldwide recently since it offers a wider perspective in terms of promoting sustainable production and consumption with limited resources. However, few studies have investigated the barriers to CE in circular food supply chains. 
  • 1.4K
  • 30 Jun 2021
Topic Review
Tetrodotoxin for Neuropathic&Cancer Pain Relief
Tetrodotoxin (TTX) is a potent neurotoxin found mainly in puffer fish and other marine and terrestrial animals. TTX blocks voltage-gated sodium channels (VGSCs) which are typically classified as TTX-sensitive or TTX-resistant channels. VGSCs play a key role in pain signaling and some TTX-sensitive VGSCs are highly expressed by adult primary sensory neurons. During pathological pain conditions, such as neuropathic pain, upregulation of some TTX-sensitive VGSCs, including the massive re-expression of the embryonic VGSC subtype NaV1.3 in adult primary sensory neurons, contribute to painful hypersensitization. In addition, people with loss-of-function mutations in the VGSC subtype NaV1.7 present congenital insensitive to pain. TTX displays a prominent analgesic effect in several models of neuropathic pain in rodents. According to this promising preclinical evidence, TTX is currently under clinical development for chemo-therapy-induced neuropathic pain and cancer-related pain.
  • 1.4K
  • 21 Jul 2021
Topic Review
Aryl Hydrocarbon Receptor in Atopic Dermatitis and Psoriasis
The aryl hydrocarbon receptor (AHR)/AHR-nuclear translocator (ARNT) system is a sensitive sensor for small molecular, xenobiotic chemicals of exogenous and endogenous origin, including dioxins, phytochemicals, microbial bioproducts, and tryptophan photoproducts. AHR/ARNT are abundantly expressed in the skin. Once activated, the AHR/ARNT axis strengthens skin barrier functions and accelerates epidermal terminal differentiation by upregulating filaggrin expression. In addition, AHR activation induces oxidative stress. However, some AHR ligands simultaneously activate the nuclear factor-erythroid 2-related factor-2 (NRF2) transcription factor, which is a master switch of antioxidative enzymes that neutralizes oxidative stress. 
  • 1.4K
  • 18 Oct 2021
Topic Review
Acne Syndromes and Mosaicism
Abnormal mosaicism is the coexistence of cells with at least two genotypes, by the time of birth, in an individual derived from a single zygote, which leads to a disease phenotype. Somatic mosaicism can be further categorized into segmental mosaicism and nonsegmental somatic mosaicism. Acne is a chronic illness characterized by inflammatory changes around and in the pilosebaceous units, commonly due to hormone- and inflammatory signaling-mediated factors. Several systemic disorders, such as congenital adrenal hyperplasia, polycystic ovarian syndrome, and seborrhoea-acne-hirsutism-androgenetic alopecia syndrome have classically been associated with acne. Autoinflammatory syndromes, including PAPA, PASH, PAPASH, PsAPASH, PsaPSASH, PASS, and SAPHO syndromes include acneiform lesions as a key manifestation. Mosaic germline mutations in the FGFR2 gene have been associated with Apert syndrome and nevus comedonicus, two illnesses that are accompanied by acneiform lesions.
  • 1.4K
  • 03 Dec 2021
Topic Review
Calcium Signaling in Melanoma
Calcium signaling plays important roles in physiological and pathological conditions, including cutaneous melanoma, the most lethal type of skin cancer. Intracellular calcium concentration ([Ca2+]i), cell membrane calcium channels, calcium related proteins (S100 family, E-cadherin, and calpain), and Wnt/Ca2+ pathways are related to melanogenesis and melanoma tumorigenesis and progression. Calcium signaling influences the melanoma microenvironment, including immune cells, extracellular matrix (ECM), the vascular network, and chemical and physical surroundings. Other ionic channels, such as sodium and potassium channels, are engaged in calcium-mediated pathways in melanoma. Calcium signaling serves as a promising pharmacological target in melanoma treatment, and its dysregulation might serve as a marker for melanoma prediction. 
  • 1.4K
  • 10 Feb 2022
Topic Review
Digitalization of CSR during the COVID-19 Pandemic
The COVID-19 pandemic has become a global problem since first appearing in 2020. Not only does it heavily affect the health sector, but it also spreads to other sectors such as social, economic, and education. Studies have shown that many global companies, including those based in Indonesia, contribute to the global pandemic mitigation by implementing Corporate Social Responsibility (CSR) programs. So far, the implementation of CSR is mainly focused on providing food, medicines, and vitamins, as well as medical facilities and equipment. On the other hand, other reviewed studies showed that the pandemic has transformed the CSR implementation from offline to online, also known as CSR digitalization. The limitation in mobility and strict social distancing rules by the government have resulted in this emergence of CSR digitalization initiatives.
  • 1.4K
  • 07 Mar 2022
Topic Review
Alexandrian Rite
The Alexandrian Rite is the liturgical rite used by the Oriental Orthodox Coptic Orthodox Church of Alexandria, Eritrean Orthodox Tewahedo Church and Ethiopian Orthodox Tewahedo Church, as well as by the Eastern Catholic Coptic Catholic Church, Eritrean Catholic Church, and Ethiopian Catholic Church. The Alexandrian rite's Divine Liturgy contains elements from the liturgies of Saints Mark the Evangelist (who is traditionally regarded as the first bishop of Alexandria), Basil the Great, Cyril the Great, and Gregory Nazianzus. The Liturgy of Saint Cyril is a Coptic language translation from Greek of the Liturgy of Saint Mark. The Alexandrian Rite is sub-grouped into two rites: the Coptic Rite and the Ge'ez Rite.
  • 1.4K
  • 14 Oct 2022
Topic Review
NASA Robots
NASA (National Aeronautics and Space Administration) robots are robotic devices used to aid, augment, or substitute for astronauts in order to do difficult or rote tasks such as repairs in dangerous environments (such as those with radiation or micrometeorite risks), routine procedures (video capture), etc.
  • 1.4K
  • 20 Oct 2022
Topic Review
Comparison of Source Code Hosting Facilities
A source code repository is a file archive and web hosting facility where a large amount of source code, for software or for web pages, is kept, either publicly or privately. They are often used by open-source software projects and other multi-developer projects to handle various versions. They help developers submit patches of code in an organized fashion. Often these web sites support version control, bug tracking, release management, mailing lists, and wiki-based documentation. People who write software retain their copyright when their software is posted to any code hosting facilities, including the "non-gnu" section of GNU Savannah—with the exception of contributors to Free Software Foundation (FSF)-copyrighted programs at GNU Savannah.
  • 1.4K
  • 27 Oct 2022
Topic Review
Pipe and Filter Architecture
In software engineering, a pipeline consists of a chain of processing elements (processes, threads, coroutines, functions, etc.), arranged so that the output of each element is the input of the next; the name is by analogy to a physical pipeline. Usually some amount of buffering is provided between consecutive elements. The information that flows in these pipelines is often a stream of records, bytes, or bits, and the elements of a pipeline may be called filters; this is also called the pipes and filters design pattern. Connecting elements into a pipeline is analogous to function composition. Narrowly speaking, a pipeline is linear and one-directional, though sometimes the term is applied to more general flows. For example, a primarily one-directional pipeline may have some communication in the other direction, known as a return channel or backchannel, as in the lexer hack, or a pipeline may be fully bi-directional. Flows with one-directional tree and directed acyclic graph topologies behave similarly to (linear) pipelines – the lack of cycles makes them simple – and thus may be loosely referred to as "pipelines".
  • 1.4K
  • 23 Nov 2022
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