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Topic Review
Sleep in Disorders of Consciousness
Consciousness is a multifaceted concept, involving both wakefulness, i.e., a condition of being alert that is regulated by the brainstem, and awareness, a subjective experience of any thoughts or perception or emotion. Disorders of consciousness (DOC) are usually caused by a severe acquired brain injury that leads to a loss of consciousness lasting at least 24 h. The management of sleep disorders in DOC patients is an increasingly hot topic and deserves careful diagnosis, to allow for the most accurate prognosis and the best medical treatment possible.
  • 1.4K
  • 23 Feb 2023
Topic Review
Glial Scar in Spinal Cord Injury
Spinal cord injury (SCI) is a complex tissue injury resulting in permanent and degenerating damage to the central nervous system (CNS). Detrimental cellular processes occur after SCI, including axonal degeneration, neuronal loss, neuroinflammation, reactive gliosis, and scar formation. The glial scar border forms to segregate the neural lesion and isolate spreading inflammation, reactive oxygen species, and excitotoxicity at the injury epicenter to preserve surrounding healthy tissue. The scar border is a physicochemical barrier composed of elongated astrocytes, fibroblasts, and microglia secreting chondroitin sulfate proteoglycans, collogen, and the dense extra-cellular matrix.
  • 1.4K
  • 24 Mar 2023
Topic Review
Metabolism of Acetic Acid Bacteria
Vinegar is one of the most appreciated fermented foods in European and Asian countries. In industry, its elaboration depends on numerous factors, including the nature of starter culture and raw material, as well as the production system and operational conditions. Furthermore, vinegar is obtained by the action of acetic acid bacteria (AAB) on an alcoholic medium in which ethanol is transformed into acetic acid. Besides the highlighted oxidative metabolism of AAB, their versatility and metabolic adaptability make them a taxonomic group with several biotechnological uses.
  • 1.4K
  • 25 Oct 2023
Topic Review Peer Reviewed
The Evolution of Human Social Behavior
Social life is a key feature in humans; without it, language, science, and technology would not have appeared. The inclination to engage with others is also a main source of pleasure and pain and as such a key factor for quality of life. In this paper, I shall present current knowledge on the evolutionary trajectory leading to the four main types of relations: parent–child, pair-bonding, kinship, and social life (bonding between non-kin for purposes other than breeding). These relationships are not unique to humans; they have evolved independently multiple times across the animal kingdom. In our lineage, the origins of parent–child bonding may be traced back to the early amniotes some 320 Mya (million years ago). Pair-bonding and social life most likely evolved recently. Understanding how these affiliations are rooted in the brain, particularly the role of feelings, provides valuable insights that can help us improve society.
  • 1.4K
  • 28 Feb 2024
Topic Review
Lectin Protein
Lectins are natural proteins with the ability to bind specific carbohydrates related to various microorganisms, including viruses, bacteria, fungi and parasites. Lectins have the ability to agglutinate and neutralize these pathogeneses. The delivery of the encapsulated antiviral agents or vaccines across the cell membrane can be possible by functionalized micellar and liposomal formulations. 
  • 1.4K
  • 14 Apr 2022
Topic Review
Ultrasound Contrast Agents for Therapy
The blood-brain barrier is the primary obstacle to efficient intracerebral drug delivery. Focused ultrasound, in conjunction with microbubbles, is a targeted and non-invasive way to disrupt the blood-brain barrier. Many commercially available ultrasound contrast agents and agents specifically designed for therapeutic purposes have been investigated in ultrasound-mediated blood-brain barrier opening studies. The new generation of sono-sensitive agents, such as liquid-core droplets, can also potentially disrupt the blood-brain barrier after their ultrasound-induced vaporization. 
  • 1.4K
  • 30 Jan 2021
Topic Review
Periodontitis Classification, Clinical Features and Diagnosis
Periodontitis is a clinical condition where there is chronic inflammation of the periodontium, resulting in the loss of the periodontal ligament and damage to the surrounding alveolar bone. Various microorganisms have been linked to periodontitis. Chronic inflammation is responsible for various complications which are seen in periodontitis cases. For better treatment and diagnosis, it is important to understand the association of periodontitis with other systemic diseases.
  • 1.4K
  • 31 Oct 2022
Topic Review
Digital Influencers’ Attributes for Sustainable Consumption Behavior
Organizations have become increasingly interested in using digital influencers to promote their brands and disseminate advertising messages with a high impact on their target audience. Digital influencers are beginning to be used as models for sustainable consumption behavior (for example in the fashion, food, and health sectors) by promoting environmental and sustainable values. By promoting sustainable content and disseminating messages of environmental awareness, digital influencers can help achieve the Sustainable Development Goals (SDGs).
  • 1.4K
  • 31 Aug 2023
Topic Review
RgIA
Conus regius is a marine venomous mollusk of the Conus genus that captures its prey by injecting a rich cocktail of bioactive disulfide bond rich peptides called conotoxins. These peptides selectively target a broad range of ion channels, membrane receptors, transporters, and enzymes, making them valuable pharmacological tools and potential drug leads. α-RgIA (or RgIA) is the most documented α-conotoxin described in C. regius. RgIA was identified using a PCR-based discovery method, which later allowed its synthesis using standard Fmoc chemistry. This peptide is characterized by the cysteine framework I (CC-C-C) and displays a globular disulfide connectivity. The α9α10 nAChR subtype, which is critical for mediating synaptic transmission from the medial olivocochlear to the cochlear hair cells, has also been implicated in a series of pathological conditions, including neuropathic pain, tumor proliferation, and immune-mediated disorders. Considering the high affinity of RgIA towards this receptor subtype, its discovery led to the possibility of studying the role of α9α10 nAChRs in several diseases.
  • 1.4K
  • 26 Dec 2022
Topic Review
Diamond-Bearing Ophiolite
Ophiolites are fragments of ancient oceanic crust and upper mantle, which is created at ocean spreading ridges and then emplaced on land. Ophiolite-hosted diamond discovered in ophiolitic peridotite and chromitite is considered to be a new type that has been named an ophiolite-type by Yang et al., in 2011. 
  • 1.4K
  • 22 Nov 2021
Topic Review
Targeting CDK9 for Glioblastoma Treatment
Glioblastoma is the most common and aggressive primary malignant brain tumor, and more than two-thirds of patients with glioblastoma die within two years of diagnosis. The challenges of treating this disease mainly include genetic and microenvironmental features that often render the tumor resistant to treatments. Despite extensive research efforts, only a small number of drugs tested in clinical trials have become therapies for patients. Targeting cyclin-dependent kinase 9 (CDK9) is an emerging therapeutic approach that has the potential to overcome the challenges in glioblastoma management.
  • 1.4K
  • 02 Jul 2021
Topic Review
PERK
Multiple myeloma is a bone marrow cancer that represents a severe health threat. The drugs used nowadays in chemotherapy often encounter resistance leading to a dramatic loss of their efficacy, which consequently affects patients’ survival. Previous studies have shown that the protein kinase R (PKR)-like ER kinase (PERK) pathway, which is one of the three branches of the unfolded protein response, is highly activated in multiple myeloma, possibly contributing to the chemotherapy resistance that these patients develop. In this study, we have used the compound GSK2606414, which is a PERK inhibitor, and found that myeloma cells are highly sensitive to this molecule. These effects were more pronounced when the inhibitor was used in combination with an anti-myeloma drug such as the proteasome inhibitor bortezomib, suggesting that the PERK pathway could be a potential therapeutic target for the treatment of multiple myeloma patients.
  • 1.4K
  • 02 Nov 2020
Topic Review
Filovirus
Filoviruses are among the deadliest infectious agents known to man, causing severe hemorrhagic fever, with up to 90% fatality rates. The 2014 Ebola outbreak in West Africa resulted in over 28,000 infections, demonstrating the large-scale human health and economic impact generated by filoviruses. Zaire ebolavirus is responsible for the greatest number of deaths to date and consequently there is now an approved vaccine, Ervebo, while other filovirus species have similar epidemic potential and remain without effective vaccines. Recent clinical success of REGN-EB3 and mAb-114 monoclonal antibody (mAb)-based therapies supports further investigation of this treatment approach for other filoviruses.
  • 1.4K
  • 08 Dec 2020
Topic Review
Streptococcus pyogenes
Streptococcus pyogenes, (colloquially named “group A streptococcus” (GAS)), is a Gram-positive bacterial pathogen that can cause both non-invasive and invasive disease (iGAS), as well as nonsuppurative sequelae. This includes pharyngitis, scarlet fever, impetigo, cellulitis, type II necrotizing fasciitis, streptococcal toxic shock syndrome, acute rheumatic fever and post-streptococcal glomerulonephritis.
  • 1.4K
  • 16 May 2021
Topic Review
Bone-Conducted Ultrasound
Bone-conducted ultrasound (BCU) has unique characteristics since ultrasound is audible when it is presented through bone conduction. The most interesting is its perception in patients with profound deafness. Some patients can perceive it and discriminate speech-modulated BCU. Previous reports have suggested that BCU can be used for a hearing aid or tinnitus sound therapy.
  • 1.4K
  • 09 Jun 2021
Topic Review
Mitochondria in Exercise-Induced Neuroprotection
Regular exercise is associated with pronounced health benefits. The molecular processes involved in physiological adaptations to exercise are best understood in skeletal muscle. Enhanced mitochondrial functions in muscle are central to exercise-induced adaptations. However, regular exercise also benefits the brain and is a major protective factor against neurodegenerative diseases, such as the most common age-related form of dementia, Alzheimer’s disease, or the most common neurodegenerative motor disorder, Parkinson’s disease. 
  • 1.4K
  • 25 Jun 2021
Topic Review
Alveolar Macrophages
At the early stages of life development, alveoli are colonized by embryonic macrophages, which become resident alveolar macrophages (ResAM) and self-sustain by local division. Genetic and epigenetic signatures and, to some extent, the functions of ResAM are dictated by the lung microenvironment, which uses cytokines, ligand-receptor interactions, and stroma cells to orchestrate lung homeostasis. 
  • 1.4K
  • 05 Nov 2021
Topic Review
Electroreforming of Biomass for Value-Added Products
Humanity’s overreliance on fossil fuels for chemical and energy production has resulted in uncontrollable carbon emissions that have warranted widespread concern regarding global warming. To address this issue, there is a growing body of research on renewable resources such as biomass, of which cellulose is the most abundant type. In particular, the electrochemical reforming of biomass is especially promising, as it allows greater control over valorization processes and requires milder conditions. Driven by renewable electricity, electroreforming of biomass can be green and sustainable. Moreover, green hydrogen generation can be coupled to anodic biomass electroforming, which has attracted ever-increasing attention.
  • 1.4K
  • 22 Dec 2021
Topic Review
Therapeutic Applications of Nano-Phytopharmaceuticals
Phytopharmaceuticals have been widely used globally since ancient times and acknowledged by healthcare professionals and patients for their superior therapeutic value and fewer side effects compared to modern medicines. Dose reduction, improved bioavailability, receptor-selective binding, and targeted delivery of phytopharmaceuticals can be likely achieved by molding them into specific nano-formulations. 
  • 1.4K
  • 25 Jan 2022
Topic Review
2009 Flu Pandemic Vaccine
The 2009 flu pandemic vaccines were influenza vaccines developed to protect against the pandemic H1N1/09 virus. These vaccines either contained inactivated (killed) influenza virus, or weakened live virus that could not cause influenza. The killed vaccine was injected, while the live vaccine was given as a nasal spray. Both these types of vaccine were produced by growing the virus in chicken eggs. Around three billion doses were produced, with delivery in November 2009.Cite error: Closing missing for tag providing a strong protective immune response and having similar safety profile to the usual seasonal influenza vaccine. However, about 30% of people already had some immunity to the virus, with the vaccine conferring greatest benefit on young people, since many older people are already immune through exposure to similar viruses in the past. The vaccine also provided some cross-protection against the 1918 flu pandemic strain. Early results (pre-25 December 2009) from an observational cohort of 248,000 individuals in Scotland showed the vaccine to be effective at preventing H1N1 influenza (95.0% effectiveness [95% confidence intervals 76.0–100.0%]) and influenza-related hospital admissions (64.7% [95% confidence intervals 12.0–85.8%]). Developing, testing, and manufacturing sufficient quantities of a vaccine is a process that takes many months. According to Keiji Fukuda of the World Health Organization, "There's much greater vaccine capacity than there was a few years ago, but there is not enough vaccine capacity to instantly make vaccines for the entire world's population for influenza." The nasal mist version of the vaccine started shipping on 1 October 2009.
  • 1.4K
  • 17 Oct 2022
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