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Topic Review
Automated Similarity Judgment Program
The Automated Similarity Judgment Program (ASJP) is a collaborative project applying computational approaches to comparative linguistics using a database of word lists. The database is open access and consists of 40-item basic-vocabulary lists for well over half of the world's languages. It is continuously being expanded. In addition to isolates and languages of demonstrated genealogical groups, the database includes pidgins, creoles, mixed languages, and constructed languages. Words of the database are transcribed into a simplified standard orthography (ASJPcode). The database has been used to estimate dates at which language families have diverged into daughter languages by a method related to but still different from glottochronology, to determine the homeland (Urheimat) of a proto-language, to investigate sound symbolism, to evaluate different phylogenetic methods, and several other purposes. ASJP is not widely accepted among historical linguists as an adequate method to establish or evaluate relationships between language families. It is part of the Cross-Linguistic Linked Data project hosted by the Max Planck Institute for the Science of Human History.
  • 1.4K
  • 23 Nov 2022
Topic Review
Cumulus
Cumulus is a digital asset management software designed for client/server system which is developed by Canto Software. The product line includes editions targeted to smaller organizations and larger enterprises. The product makes use of metadata for indexing, organizing, and searching.
  • 1.4K
  • 06 Dec 2022
Topic Review
Application of CRISPR/Cas Systems in Fungal Genetic Engineering
Fungi represent an important source of bioactive secondary metabolites (SMs), which have wide applications in many fields, including medicine, agriculture, human health, and many other industries. The genes involved in SM biosynthesis are usually clustered adjacent to each other into a region known as a biosynthetic gene cluster (BGC). The advanced CRISPR/Cas system has revolutionized fungal genetic engineering and enabled the discovery of novel bioactive compounds. 
  • 1.4K
  • 29 Mar 2023
Topic Review
Classification of Phenolic Antioxidants
Phenolic compounds are classified as primary antioxidants and originate from one of the main classes of secondary metabolites in plants. They have antioxidant properties through several mechanisms: (i) the ability to remove free radicals and inhibit the formation of reactive species during the normal course of metabolism; (ii) preventing the occurrence of damage to lipids, proteins, and nucleic acids; and (iii) preventing consequent cell damage and death. Thus, they are commonly associated with preventing the development of cardiovascular diseases, neurodegenerative diseases, autoimmune diseases, diabetes, and cancer.
  • 1.4K
  • 12 Jun 2023
Topic Review
6G Technology in Mobile-Health Multimedia
Mobile-health (m-health) is described as the application of medical sensors and mobile computing to the healthcare provision. While 5G networks can support a variety of m-health services, applications such as telesurgery, holographic communications, and augmented/virtual reality are already emphasizing their limitations. These limitations apply to both the Quality of Service (QoS) and the Quality of Experience (QoE). However, 6G mobile networks are predicted to proliferate in order to solve these limitations, enabling high QoS and QoE. 
  • 1.4K
  • 10 Jul 2023
Topic Review
Lycium barbarum Deep-Processing Products of Fermentation
Lycium barbarum, a homology of medicine and food, contains many active ingredients including polysaccharides, polyphenol, betaine, and carotenoids, which has health benefits and economic value. The bioactive components in Lycium barbarum exhibit the effects of antioxidation, immune regulation, hypoglycemic effects, and vision improvement.
  • 1.4K
  • 04 Mar 2024
Topic Review
Nod-Like Receptors
The nucleotide-binding domain and leucine-rich-repeat-containing family (NLRs) (sometimes called the NOD-like receptors, though the family contains few bona fide receptors) are a superfamily of multidomain-containing proteins that detect cellular stress and microbial infection.
  • 1.4K
  • 29 Jun 2021
Topic Review
Bimetallic Nanomaterials
Bimetallic nanomaterials (BMNs) are one kind of innovative nanomaterials, referring to nano-bimetallic alloy, intermetallic compounds, or the combination of two kinds of metallic nanoparticles. Compared with monometallic nanomaterials, BMNs perform similar or even better physical and chemical properties in the medical field. BMNs possess excellent physical and chemical properties, such as easy surface modification, superior photothermal properties, multiple catalytic properties, delicate sensitivity, and good stability. Synthesis methods of bimetallic nanomaterials. The preparation methods of BMNs commonly used for cancer therapy, such as co-reduction method, hydrothermal method, seed-mediated growth method, and electrodeposition method.
  • 1.4K
  • 21 Dec 2022
Topic Review
Efficient Task Offloading in Multi-User Edge Computing
Task offloading is one of the most important issues in edge computing and has attracted continuous research attention in recent years. With task offloading, end devices can offload the entire task or only subtasks to the edge servers to meet the delay and energy requirements.
  • 1.4K
  • 05 Aug 2022
Topic Review
Cancer Therapy (Radiation)-Induced Immune Modulation
Cancer therapy-related cardiopulmonary dysfunction (CTRCPD) is one of the most undesirable side effects of cancer therapy and leads to limitations to cancer treatment. Chemoradiation therapy or immunotherapy promote acute and chronic cardiopulmonary damage by inducing reactive oxygen species, DNA damage, inflammation, fibrosis, deregulation of cellular immunity, cardiopulmonary failure, and non-malignant related deaths among cancer-free patients who received cancer therapy. The efficacy of the radiation depends on the degree of DNA damage, which results in cancer cell death.
  • 1.4K
  • 14 Sep 2022
Topic Review
Vicar Apostolic
An apostolic vicariate is a form of territorial jurisdiction of the Catholic Church centered in missionary regions and countries where a diocese has not yet been established. It is essentially provisional, though it may last for a century or more. The hope is that the region will generate sufficient numbers of Catholics for the Church to create a diocese. In turn, the status of Apostolic vicariate is often a promotion for a former apostolic prefecture, while either may have started out as a mission sui iuris.
  • 1.4K
  • 26 Oct 2022
Topic Review
Paleoparasitology
Paleoparasitology aims to study the natural history of parasitic organisms through the recovery of their preserved remains in archaeological, paleontological, paleoecological, and medical contexts. 
  • 1.4K
  • 29 Jun 2021
Topic Review
Sphingosine 1-phosphate
The breakdown of the endothelial cell (EC) barrier contributes significantly to sepsis mortality. Sphingosine 1-phosphate (S1P) is one of the most effective EC barrier-stabilizing signaling molecules. Stabilization is mainly transduced via the S1P receptor type 1 (S1PR1). Here, we demonstrate that S1P was autonomously produced by ECs. S1P secretion was significantly higher in primary human umbilical vein endothelial cells (HUVEC) compared to the endothelial cell line EA.hy926. Constitutive barrier stability of HUVEC, but not EA.hy926, was significantly compromised by the S1PR1 antagonist W146 and by the anti-S1P antibody Sphingomab. HUVEC and EA.hy926 differed in the expression of the S1P-transporter Spns2, which allowed HUVEC, but not EA.hy926, to secrete S1P into the extracellular space. Spns2 deficient mice showed increased serum albumin leakage in bronchoalveolar lavage fluid (BALF). Lung ECs isolated from Spns2 deficient mice revealed increased leakage of fluorescein isothiocyanate (FITC) labeled dextran and decreased resistance in electric cell-substrate impedance sensing (ECIS) measurements. Spns2 was down-regulated in HUVEC after stimulation with pro-inflammatory cytokines and lipopolysaccharides (LPS), which contributed to destabilization of the EC barrier. Our work suggests a new mechanism for barrier integrity maintenance. Secretion of S1P by EC via Spns2 contributed to constitutive EC barrier maintenance, which was disrupted under inflammatory conditions via the down-regulation of the S1P-transporter Spns2.
  • 1.4K
  • 30 Oct 2020
Topic Review
Statins in β-cells
Statins are the gold standard treatment in patients with familial hypercholesterolemia due to their effectiveness reducing circulating cholesterol levels and their low cost. However, increasing evidence shows a clear relation between long term statin treatment and new-onset type 2 diabetes mellitus (T2DM) development. However, the mechanisms by which statin treatment induces T2DM are not fully understood. Recent evidences suggest that statins could increase circulating glucose levels inducing insulin resistance in peripheral tissues and modulating insulin sensitivity and secretion in beta-cells. It has been described that calcium signaling, a key process that allows insulin-containing vesicle mobilization is impaired in the beta-cells under statin treatment, the expression and mobilization of glucose transporters are also reduced and insulin signaling pathway is down regulated after statin treatment. All together contribute to glucose and insulin homeostasis deregulation and favors T2DM development.
  • 1.4K
  • 09 Nov 2020
Topic Review
Solid-State NMR
Solid-state NMR is a structural biology approach that can provide information about large molecular assemblies at the atomic level. Contrary to solution-state NMR, it does not have any theoretical size limitation, and is performed on solids, i.e. sediments, crystals or powders which are filled into so-called 'NMR rotors'. To average some interactions, solid-state NMR requires to spin the rotors at the 'magic' angle and at high spinning frequencies. The NMR chemical shifts give a fingerprint of molecules, which can be used to characterize structural differences, and can be applied to different types of proteins such as viral capsids, membrane proteins, amyloid fibrils, etc...
  • 1.4K
  • 13 Oct 2020
Topic Review
Resistant Breeding and MAS
Clubroot is a major disease for the brassica crops, and it can not completely control by any other means except the resistant caultivars. MAS breeding helps us for the development of new resistant cultivars
  • 1.4K
  • 13 Jan 2021
Topic Review
HSP70 in Cancer
The 70-kDa heat shock proteins (HSP70s) are abundantly present in cancer, providing malignant cells selective advantage by suppressing multiple apoptotic pathways, regulating necrosis, bypassing cellular senescence program, interfering with tumor immunity, promoting angiogenesis and supporting metastasis. This direct involvement of HSP70 in most of the cancer hallmarks explains the phenomenon of cancer “addiction” to HSP70, tightly linking tumor survival and growth to the HSP70 expression. HSP70 operates in different states through its catalytic cycle, suggesting that it can multi-function in malignant cells in any of these states. Clinically, tumor cells intensively release HSP70 in extracellular microenvironment, resulting in diverse outcomes for patient survival. Given its clinical significance, small molecule inhibitors were developed to target different sites of the HSP70 machinery. Furthermore, several HSP70-based immunotherapy approaches were assessed in clinical trials.
  • 1.4K
  • 19 May 2021
Topic Review
Multiplexed Nanobiosensors
Nanobiosensors are sensors in which various nanosize materials are used, however, large equipment is still required for whole sensing systems, because they are not, by themselves, able to detect nanoscale events. The current state-of-the-art nanobiosensors are based on several diagnostic methods, such as enzyme-linked immunosorbent assay (ELISA), flow cytometric immunoassay, electrochemical (amperometric, voltammetric and impedance), immunoassay, mass spectrometric immunoassay, chromatographic immunoassay, and different optical immunoassays. Contemporary multiplexed nanobiosensors are developed for the detection and quantification of clinically relevant analytes in biological and clinical samples (i.e., blood, urine, and saliva).
  • 1.4K
  • 23 Jun 2021
Topic Review
General Features of Micropropagation
Organogenesis and somatic embryogenesis are the two substitute pathways in plant micropropagation [16]. However, some literature emphasised the shoot proliferation as a separate class of Eucalyptus micropropagation method. To better understand the prospects of in vitro scenarios, in the coming section, we briefly describe the concepts of organogenesis and somatic embryogenesis in Eucalyptus.
  • 1.4K
  • 19 Jul 2021
Topic Review
Cyber and Offline Dating Abuse
 The increasing use of information and communication technologies (ICT) and networking has promoted the occurrence of different forms of victimization, specifically in terms of interpersonal interaction (e.g., cyberbullying or online risk-taking behaviour), which also includes cyber dating abuse (CDA). Some studies report that CDA is an extension of offline dating abuse (ODA). 
  • 1.4K
  • 11 Aug 2021
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