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Topic Review
Glioblastoma Cells
Glioblastoma multiforme (GBM) is the most common brain cancer in adults. GBM starts from a small fraction of poorly differentiated and aggressive cancer stem cells (CSCs) responsible for aberrant proliferation and invasion. Due to extreme tumor heterogeneity, actual therapies provide poor positive outcomes, and cancers usually recur. Therefore, alternative approaches, possibly targeting CSCs, are necessary against GBM.
  • 1.4K
  • 31 Mar 2022
Topic Review
3D Bioprinting for Pancreas Engineering/Manufacturing
Diabetes is the most common chronic disease in the world, and it brings a heavy burden to people’s health. Against this background, diabetic research, including islet functionalization has become a hot topic in medical institutions all over the world. Especially with the rapid development of microencapsulation and three-dimensional (3D) bioprinting technologies, organ engineering and manufacturing have become the main trends for disease modeling and drug screening. Especially the advanced 3D models of pancreatic islets have shown better physiological functions than monolayer cultures, suggesting their potential in elucidating the behaviors of cells under different growth environments.
  • 1.4K
  • 12 Dec 2022
Topic Review
Optoacoustic Imaging
Optoacoustic or photoacoustic imaging (OAI/PAI) has the unique ability and scalability to visualize, monitor, and understand the molecular mechanisms of inflammation.
  • 1.4K
  • 20 May 2021
Topic Review
Biomedical Applications of Microfluidic Devices
Both passive and active microfluidic chips are used in many biomedical and chemical applications to support fluid mixing, particle manipulations, and signal detection. Passive microfluidic devices are geometry-dependent, and their uses are rather limited. Active microfluidic devices include sensors or detectors that transduce chemical, biological, and physical changes into electrical or optical signals. Also, they are transduction devices that detect biological and chemical changes in biomedical applications, and they are highly versatile microfluidic tools for disease diagnosis and organ modeling. Microfluidic devices are fabricated using a range of techniques, including molding, etching, three-dimensional printing, and nanofabrication. Their broad utility lies in the detection of diagnostic biomarkers and organ-on-chip approaches that permit disease modeling in cancer, as well as uses in neurological, cardiovascular, hepatic, and pulmonary diseases. Biosensor applications allow for point-of-care testing, using assays based on enzymes, nanozymes, antibodies, or nucleic acids (DNA or RNA). 
  • 1.4K
  • 02 Dec 2022
Topic Review
Locomotion Assistive Devices
Locomotion assistive devices equipped with a microprocessor can potentially automatically adapt their behavior when the user is transitioning from one locomotion mode to another. Many developments in the field have come from machine learning driven controllers on locomotion assistive devices that recognize/predict the current locomotion mode or the upcoming one.
  • 1.4K
  • 24 Nov 2020
Topic Review
Bone Marrow
Bone marrow (BM) is a reliable source of multipotent mesenchymal stromal cells (MSCs), which have been successfully used for treating osteonecrosis.
  • 1.4K
  • 31 Jan 2022
Topic Review
Sensors Based on Electrical Activity for HR Monitoring
Heart rate (HR) is the rate at which the heart pumps and is measured by the number of contractions (beats) of the heart per minute (bpm). Extramural monitoring opens the way to a prolonged and extended evaluation of the heart rhythm, which has several advantages for both the diagnosis of pathology and the prevention of adverse events related to heart disease.
  • 1.4K
  • 06 Jun 2022
Topic Review
Robot-Assisted Endovascular Interventions Technologies and Application
Prior methods of patient care have changed in recent years due to the availability of minimally invasive surgical platforms for endovascular interventions. These platforms have demonstrated the ability to improve patients’ vascular intervention outcomes, and global morbidities and mortalities from vascular disease are decreasing. 
  • 1.4K
  • 28 Jan 2023
Topic Review
Wearable Technology for Monitoring Electrocardiograms in Adults
In the rapidly evolving landscape of continuous electrocardiogram (ECG) monitoring systems, there is a heightened demand for non-invasive sensors capable of measuring ECGs and detecting heart rate variability (HRV) in diverse populations, ranging from cardiovascular patients to sports enthusiasts. Challenges like device accuracy, patient privacy, signal noise, and long-term safety impede the use of wearable devices in clinical practice.
  • 1.4K
  • 27 Feb 2024
Topic Review
MIMO Radars
This entry reports a thorough overview on the last developments concerning the vital sign detection and the human localization employing the multiple-input-multiple-output (MIMO) technology. The wireless motion and vital sign detection represents an outstanding research area aimed at monitoring the health conditions of human subjects and at detecting their presence in different environments with minimal concern. MIMO radars exhibit several interesting advantages over conventional single-input-single-output architectures mainly related to their angle detection capabilities and enhanced signal-to-noise ratio. This paper describes the main features and details the operating principles of MIMO technology. Thereafter, it summarizes the state-of-the-art of the available solutions with the purpose of fueling the research activities on this hot topic.
  • 1.4K
  • 17 Sep 2020
Topic Review
Functional Nanozyme
Nanozymes have the potential to replace natural enzymes, so they are widely used in energy conversion technologies such as biosensors and signal transduction (converting biological signals of a target into optical, electrical, or metabolic signals). The participation of nucleic acids leads nanozymes to produce richer interface effects and gives energy conversion events more attractive characteristics, creating what are called “functional nanozymes”. 
  • 1.4K
  • 15 Jun 2021
Topic Review
Spinal Robotic Orthoses
Osteoporotic spine fractures (OSF) are common sequelae of osteoporosis. OSF are directly correlated with increasing age and incidence of osteoporosis. OSF are treated conservatively or surgically. We review the current state of the art in the field of wearable robots for trunk support.
  • 1.4K
  • 19 Feb 2021
Topic Review
Artificial Intelligence and Machine Learning for Biocatalysis
Biocatalysis is currently a workhorse used to produce a wide array of compounds, from bulk to fine chemicals, in a green and sustainable manner. The success of biocatalysis is largely thanks to an enlargement of the feasible chemical reaction toolbox. This materialized due to major advances in enzyme screening tools and methods, together with high-throughput laboratory techniques for biocatalyst optimization through enzyme engineering. Therefore, enzyme-related knowledge has significantly increased. To handle the large number of data now available, computational approaches have been gaining relevance in biocatalysis, among them machine learning methods (MLMs). MLMs use data and algorithms to learn and improve from experience automatically. 
  • 1.4K
  • 14 Jun 2023
Topic Review
Optical Detection of Pathogenic Bacteria
The optical detection of pathogenic bacteria is a growing area of ongoing research for clinically-focused applications. Different modalities, like vibrational spectroscopy, fluorescence, scattering- and polarization-based systems, have the potential to provide information about the biomolecular and morphological characteristics of a species for sample identification and differentiation. Additionally, growth pattern recognition, single-cell versus biofilm formations, cell motility and viability, cell mutation, and antibiotic resistance status can be studied with various optical modalities, providing great potential for rapid characterization of disease-causing pathogens.
  • 1.4K
  • 03 Dec 2020
Topic Review
Printed Electrochemical Biosensors
Printing technologies represent powerful tools to combine simpler and more customizable fabrication of electrochemical biosensors with high resolution, miniaturization and integration with more complex microfluidic and electronics systems. Considering this framework, this review provides an overview of the opportunities offered by printed electrochemical biosensors in terms of transducing principles, metrological characteristics and enlargement of the application field, as well as of the main metrological challenges related.
  • 1.4K
  • 14 Dec 2020
Topic Review
Fiber-Optical Sensors for Bio-Mechatronics Applications
Bio-mechatronics is an interdisciplinary scientific field that emphasizes the integration of biology and mechatronics to discover innovative solutions for numerous biomedical applications. The broad application spectrum of bio-mechatronics consists of minimally invasive surgeries, rehabilitation, development of prosthetics, and soft wearables to find engineering solutions for the human body. Fiber-optic-based sensors have become an indispensable part of bio-mechatronics systems, which are essential for position detection and control, monitoring measurements, compliance control, and various feedback applications. 
  • 1.4K
  • 01 Dec 2023
Topic Review
3D Bioprinting Techniques
Additive manufacturing, more often referred to as “3D printing,” is the method of fabricating three-dimensional objects by adding successive layers of materials at a regulated rate and thickness. These materials could be made of concrete, metals, ceramics, polymers, resins, biomaterials, or other substances. The dearth of variety in 3D-printable materials continues even though printing time, processing speed, and printing resolution have all increased. The compatibility and flowability of printing ink with the current printing procedures are crucial for developing fields such as the 3D printing of biomaterials, tissues, and high-viability cells.
  • 1.4K
  • 12 Dec 2022
Topic Review
Additively Manufactured Polylactic Acid in Dentistry
Additive manufacturing (AM), which is also called rapid prototyping/3D printing/layered manufacturing, can be considered as a rapid conversion between digital and physical models. One of the most used materials in AM is polylactic acid (PLA), which has advantageous material properties such as biocompatibility, biodegradability, and nontoxicity. For many medical applications, it is considered as a leading biomaterial. In dentistry, in addition to its uses in dental models (education, teaching, simulation needs), it can be used for therapeutic objectives and tissue engineering.
  • 1.4K
  • 28 Jun 2023
Topic Review
Pap Smear Images Classification with Machine Learning
Cervical cancer is regularly diagnosed in women all over the world. This cancer is the seventh most frequent cancer globally and the fourth most prevalent cancer among women. Automated and higher accuracy of cervical cancer classification methods are needed for the early diagnosis of cancer. In addition, routine Pap smears could enhance clinical outcomes by facilitating the early diagnosis of cervical cancer. Liquid-based cytology (LBC)/Pap smears for advanced cervical screening is a highly effective precancerous cell detection technology based on cell image analysis, where cells are classed as normal or abnormal. Computer-aided systems in medical imaging have benefited greatly from extraordinary developments in artificial intelligence (AI) technology.
  • 1.4K
  • 02 Dec 2022
Topic Review
Glucose Monitoring
Glucose monitoring is essential to control diabetes and avoid long-term complications. Diabetics suffer on a daily basis with the traditional glucose monitors currently in use, which are invasive, painful, and cost-intensive. Therefore, the demand for non-invasive, painless, economical, and reliable approaches to monitor glucose levels is increasing.
  • 1.4K
  • 30 Oct 2021
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