From Caveolae Compartmentalization of Signal Transduction to Medicine

Subjects: Molecular Biology
Created by: Shengwen-calvin Li

The caveolin molecule is simply amazing. Understanding how the Caveolin  family works in the human body is not simple. The caveolin-mediated caveolae, cellular organelles of the cell, regulate the physiology of the human body by communicating with one another, while dysfunctional caveolae lead to pathogenesis. Since the four of us started studying caveolae when we worked at the Whitehead Institute for Biomedical Research of the Massachusetts Institute of Technology (MIT) in Michael P. Lisanti’s laboratory, we have mapped out the caveolin-scaffolding domain (CSD) within the caveolin family molecules and defined the CSD-interacting motifs within multiple lines of receptors involved in signal transduction. We have also established models for studying caveolae (i.e., lipid rafts) genesis. Functionally, we found that the CSD acts as a negative regulator of signal transduction, which inspired
 the development of therapeutics for diseases. In the past decade or so,  we have witnessed the discovery of new regulating networks of caveolae-mediated communication and the dysfunction of caveolae related to pathogeneses and cancer.

the article

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Caveolin-1 (CAV1) is a scaffolding protein with a controversial role in cancer. This review will initially discuss earlier studies focused on the role as a tumor suppressor before elaborating subsequently on those relating to function of the protein as a promoter of metastasis. Different mechanisms are summarized illustrating how CAV1 promotes such traits upon expression in cancer cells (intrinsic mechanisms). More recently, it has become apparent that CAV1 is also a secreted protein that can be included into exosomes where it plays a significant role in determining cargo composition. Thus, we will also discuss how CAV1 containing exosomes from metastatic cells promote malignant traits in more benign recipient cells (extrinsic mechanisms). This ability appears, at least in part, attributable to the transfer of specific cargos present due to CAV1 rather than the transfer of CAV1 itself. The evolution of how our perception of CAV1 function has changed since its discovery is summarized graphically in a time line figure.

Cell Intrinsic and Extrinsic Mechanisms of Caveolin-1-Enhanced Metastasis

Cited article "Cell Intrinsic and Extrinsic
Mechanisms of Caveolin-1-Enhanced Metastasis" has been published in
Biomolecules as part of the Special Issue Beyond Lipid Rafts and Caveolae:
From Caveolae Compartmentalization of Signal Transduction to Medicine and is
available online:

Abstract: https://www.mdpi.com/2218-273X/9/8/314
PDF Version: https://www.mdpi.com/2218-273X/9/8/314/pdf
Special Issue:

Ref.: A special issue of "Biomolecules (ISSN 2218-273X)" - (Published by MDPI AG, Basel, Switzerland) Deadline for manuscript submissions: 15 June 2020

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 Special Issue Editors

   Guest Editor
 Dr. Shengwen Calvin Li
 University of California, Irvine
CHOC Children's Hospital Research Institute
 Website | E-Mail
 Interests: brain tumors; cancer stem cells; immunotherapy; neural stem
 cells; iPSCs

   Guest Editor
 Dr. Massimo Sargiacomo
 Research Director, Istituto Superiore di Sanità, Rome, Italy
 Website | E-Mail

   Guest Editor
 Prof. Jacques Couet
 Faculty of Medicine, Laval University, Québec City, Canada
 Website | E-Mail

   Guest Editor
 Prof. Eric Kübler
 Fachhochschule Nordwestschweiz FHNW (University of Applied Sciences and
 Arts Northwestern Switzerland FHNW), Basel, Switzerland
 Website | E-Mail

Cite this article

Shengwen-Calvin, Li. From Caveolae Compartmentalization of Signal Transduction to Medicine, Encyclopedia, 2019, v2, Available online: https://encyclopedia.pub/255