Accurate prenatal diagnosis of cleft lip and palate is essential for predicting severity, providing appropriate parental counseling, and establishing long-term treatment plans. In a systematic review conducted to evaluate the accuracy of various imaging techniques for prenatal diagnosis of these conditions, researchers analyzed studies published up to January 2024 from several major databases including PubMed, EMBASE, Scopus, and Web of Science. The quality of the included studies was assessed using the Newcastle–Ottawa scale for cohort studies and the QUADAS-2 tool for diagnostic accuracy studies. Among the 18 studies that met the eligibility criteria, the findings consistently demonstrated that supplementing traditional 2D ultrasound with advanced imaging techniques such as 3D ultrasound or magnetic resonance imaging significantly improved diagnostic accuracy. The video concluded that incorporating magnetic resonance imaging as a standard procedure could greatly enhance the precision of diagnosing cleft lip and palate, underscoring the critical role of the chosen diagnostic technique in achieving accurate results.