Sort:
Show:
Page Size:
Topic review
Updated time: 18 May 2021
Submitted by: Hui Min Neoh
Definition: The 16S rRNA gene is highly conserved in all bacteria (and also archaea). Nonetheless, it contains nine hypervariable regions (V1 - V9), where sequences of these regions can be used to identify and discriminate bacterial genus, sometimes until the species level. This makes the gene a useful tool for phylogenetic studies. With the introduction of next-generation sequencing technologies, 16S rRNA next-generation sequencing (16SNGS) has allowed profiling of bacterial communities found in organisms and the environment, and lead to the discovery of many previously unculturable members of the bacteria kingdom.
Unfold
Topic review
Updated time: 05 Sep 2021
Submitted by: Ahmed Sherif Attia
Definition: Acinetobacter baumannii is an emerging pathogen, and over the last three decades it has proven to be particularly difficult to treat by healthcare services. It is now regarded as a formidable infectious agent with a genetic setup for prompt development of resistance to most of the available antimicrobial agents. we provide a comprehensive updated overview of the available data about A. baumannii, the multi-drug resistant (MDR) phenotype spread, carbapenem-resistance, and the associated genetic resistance determinants in low-income countries (LIICs) since the beginning of the 21st century.
Entry Collection : COVID-19
Unfold
Topic review
Updated time: 04 Jun 2021
Submitted by: Hans-Peter Fiedler
Definition: Abyssomicins represent a new family of polycyclic macrolactones. The first described compounds of the abyssomicin family were abyssomicin B, C, atrop-C, and D, produced by the marine actinomycete strain Verrucosispora maris AB-18-032, which was isolated from a sediment collected in the Sea of Japan. Among the described abyssomicins, only abyssomicin C and atrop-abyssomicin C show a high antibiotic activity against Gram-positive bacteria, including multi-resistant and vancomycin-resistant strains. The inhibitory activity is caused by a selective inhibition of the enzyme 4-amino-4-deoxychorismate synthase, which catalyzes the transformation of chorismate to para-aminobenzoic acid, an intermediate in the folic acid pathway.
Unfold
Topic review
Updated time: 26 Oct 2020
Definition: Antibiotic resistance is one of the biggest challenges for the clinical sector and industry, environment and societal development. One of the most important pathogens responsible for severe nosocomial infections isAcinetobacter baumannii, a Gram-negative bacterium from the Moraxellaceae family, due to its various resistance mechanisms.The enormous adaptive capacity ofA. baumanniiand the acquisition and transfer of antibiotic resistance determinants contribute to the ineffectiveness of most current therapeutic strategies, including last-line or combined antibiotic therapy. In this review, we will present the current progress in developing innovative strategies for combating multidrug-resistantA. baumannii(MDRAB) infections.
Unfold
Topic review
Updated time: 05 Aug 2021
Submitted by: MUHANNA ALSHAIBANI
Definition: Actinobacteria are among the secondary metabolites producers and hold high pharmacological and commercial interest. It has great capability to produce secondary metabolites such as immunomodulators, antibiotics, anti-cancer drugs, growth factors, anthelminthic enzymes and herbicides.describes the historical isolation of bioactive compounds from Actinobacteria from the first isolation by Selman Waksman.
Unfold
Topic review
Updated time: 02 Dec 2020
Submitted by: Valeria Blanda
Definition: Interactions between tick-borne pathogenic hemoparasites and different host effector mechanisms of T- and/or B cell-mediated adaptive immunity, involved in the late and long-lasting protective immune response.
Unfold
Topic review
Updated time: 05 Jan 2021
Submitted by: Pablo C. Baldi
Definition: A central aspect of Brucella pathogenicity is its ability to invade, survive, and replicate in diverse phagocytic and non-phagocytic cell types, leading to chronic infections and chronic inflammatory phenomena. Adhesion to the target cell is a critical first step in the invasion process. Several Brucella adhesins have been shown to mediate adhesion to cells, extracellular matrix components (ECM), or both. These include the sialic acid-binding proteins SP29 and SP41, the BigA and BigB proteins that contain an Ig-like domain, the monomeric autotransporters BmaA, BmaB, and BmaC, the trimeric autotransporters BtaE and BtaF, and Bp26.
Unfold
Topic review
Updated time: 23 Jun 2021
Submitted by: Franziska Hornung
Definition: The alterations of adipocyte-derived signal mediators strongly influence the regulation of inflammation, resulting in chronic low-grade inflammation.
Unfold
Topic review
Updated time: 25 Jan 2021
Submitted by: Toru Yoshida
Definition: ADP-ribosyltransferases (ARTs) are a well-known type of bacterial toxin. They transfer an ADP-ribose moiety from nicotinamide adenine dinucleotide (NAD+) onto a target protein to generate an ADP-ribosylated protein and nicotinamide. The bulky and negatively charged ADP-ribose moiety affects the protein function by sterically blocking interactions with partner molecules, inducing conformational changes, or creating docking sites for new interaction partners.
Unfold
Topic review
Updated time: 17 Dec 2020
Submitted by: Brijesh Tiwari
Definition: Air is recognized as an important source of microbial contamination in food production facilities and has the potential to contaminate the food product causing food safety and spoilage issues for the food industry. Potential for aerial microbial contamination of food can be a particular issue during storage in cold rooms when the food is not packaged and is exposed to contaminated air over a prolonged period. Thus, there are potential benefits for the food industry for an aerial decontamination in cold storage facilities. It is considered that current systems may not be completely effective and environmentally friendly, therefore, it is of great significance to consider the development of nonresidual and verified decontamination technologies for the food industry and, in particular, for the cold storage rooms.
Unfold
  • Page
  • of
  • 38