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Biology & Life Sciences / Cell & Developmental Biology

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Triple-negative breast cancer (TNBC) is a highly "aggressive" malignant neoplasm with limited...
Figure 1. Location of the HCP5 gene (d) within the ERV16 element (c) and the human leukocyte antigen (HLA) class I region of the beta-block (b) on chromosome 6 at 6p21.33 (a). The HLA class I promoter region (the green rectangle labeled as Pr) for the 2630 bp HCP5 gene (d) initiates transcription of the 2547 bp lnc HCP5 RNA (e). The 91 bp intron in the HCP5 gene is represented by the thin grey line between the violet rectangular lines (d). The AluSp, THE1B, and LTR162B insertions within the 6173 bp ERV16 sequence [30] (c) are indicated by the labeled circle, triangle, and rectangles, respectively (see Table 1 for more details). The H3K27Ac binding (orange curve) and Dnase I hypersensitivity region (grey horizontal rectangle) associated with the HCP5 gene sequence (d) and sourced from the University of California, Santa Cruz (UCSC) genomic browser (Table S1) are shown on line (f).
The HCP5 RNA gene (NCBI ID: 10866) is located centromeric of the HLA-Bgene and between the MICAand...