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Topic review
Updated time: 03 Jul 2021
Submitted by: Ramona Dobre
Definition: The role of anti-osteoporotic treatment as part of the secondary prevention after hip fracture in terms of mortality and re-fracture risk has been studied, and the results are promising. Lower mortality after hip fracture is associated with anti-osteoporotic treatment.
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Topic review
Updated time: 19 May 2021
Submitted by: Daniel Santana
Definition: Total hip and knee arthroplasty are common major orthopedic operations being performed on an increasing number of patients. Many patients undergoing total joint arthroplasty (TJA) are on chronic antithrombotic agents due to other medical conditions, such as atrial fibrillation or acute coronary syndrome. Given the risk of bleeding associated with TJAs, as well as the risk of thromboembolic events in the post-operative period, the management of chronic antithrombotic agents perioperatively is critical to achieving successful outcomes in arthroplasty.
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Topic review
Updated time: 10 Jun 2021
Submitted by: Samo Fokter
Definition: Titanium (Ti) alloys have been proven to be one of the most suitable materials for orthopaedic implants. Dual modular stems have been introduced to primary total hip arthroplasty (THA) to enable better control of the femoral offset, leg length, and hip stability. However, this recent innovation in the femoral stem design has proven itself to be an innovation trap actually.
Entry Collection : Pain and Chronic Pain
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Topic review
Updated time: 21 Jun 2021
Submitted by: Dror Paley
Definition: Fibular hemimelia (FH) is the most common lower-extremity congenital longitudinal deficiency, with occurrence between 1:135,000 and 1:50,000 births. It is associated with a constellation of deformities that fall into five general categories: tibial deformity, genu valgum, knee instability, leg length discrepancy (LLD) and foot and ankle deformities and deficiencies. Both deformities and leg length discrepancy in FH can present with a wide spectrum from mild to severe .
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Topic review
Updated time: 29 Jun 2021
Submitted by: Joel Zagoya
Definition: There are different alternatives when selecting removable prostheses for below the knee amputated patients. The designs of these prostheses vary according to their different functions. These prostheses designs can be classified into Energy Storing and Return (ESAR), Controlled Energy Storing and Return (CESR), active, and hybrid. This paper aims to identify the state of the art related to the design of these prostheses of which ESAR prostheses are grouped into five types, and active and CESR are categorized into four groups. Regarding patent analysis, 324 were analyzed over the last six years.
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Topic review
Updated time: 22 Jul 2021
Submitted by: Moritz Pfeiffenberger
Definition: Fractures are one of the most frequently occurring traumatic events worldwide.
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Topic review
Updated time: 24 May 2021
Submitted by: Hanna Taipaleenmäki
Definition: Interleukins (ILs) regulate differentiation and function of bone cells, with several ILs being reported to act pro-osteoclastogenic.
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Topic review
Updated time: 09 Jul 2021
Submitted by: Olga Adamska
Definition: KD is an eponym for a delayed post-traumatic bone osteonecrosis. Patients usually present with advanced stage kyphosis in the thoracolumbar (T-L) area within months to years after experiencing a minor trauma, initially presenting without any symptoms. Possible causes include avascular osteonecrosis, microfracture, atrophic nonunion, and a nutritional injury fracture.
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Topic review
Updated time: 29 Apr 2021
Submitted by: Raf Sciot
Definition: Murine Double Minute Clone 2, located at 12q15, is an oncogene that codes for an oncoprotein of which the association with p53 was discovered 30 years ago. The most important function of MDM2 is to control p53 activity. The sarcomas that typically have an amplification of MDM2.
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Topic review
Updated time: 12 Jul 2021
Submitted by: Jingzhi Fan
Definition: Identifying the changes in endogenous metabolites in response to intrinsic and extrinsic factors has excellent potential to obtain an understanding of cells, biofluids, tissues, or organisms’ functions and interactions with the environment. The advantages provided by the metabolomics strategy have promoted studies in bone research fields, including an understanding of bone cell behaviors, diagnosis and prognosis of diseases, and the development of treatment methods such as implanted biomaterials.
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