Encyclopedia
The main aim of my laboratory is to develop smart and synergistic approaches which ultimately will contribute to a more rational application in therapy.
06 Jul 2023
(a) Structure of exosome depicting the molecular components; the phospholipid bilayer (blue colored) encloses the vesicle. Internally, the vesicle consists of cargo comprising nucleic acids, proteins, and lipids.
(b) The biogenesis of exosomes involves (1) cargo from the extracellular space entering the cytosol through internalization wherein it forms the early endosome. (2) Early endosomes mature to form multivesicular bodies (MVBs) consisting of intraluminal vesicles that include tetraspanin (CD9, CD63, and CD81), an endosomal sorting complex required for transport (ESCRT) proteins (Alix, TSG101), integrins, heat shock proteins, cytoskeletal proteins, and membrane transport proteins. (3) Cargo internalization consists of cargo delivery from the trans-Golgi network and the cytosol. (4) MVBs consisting of exosome cargo are transported to the plasma membrane (PM) with the help of a microtubule network and Rab GTPases. (5) SNAREs dock the MVBs to the PM and ILVs are secreted as exosomes.
02 Oct 2023
This Figure shows the dynamics of the increase in genome size in variuos rye species, genus Secale, due to the increase in the size of subtelomeric regions of chromosomes. The evolutionary dynamics can be traced from the ancestral, ancient species, S. silvestre,to the youngest, cultivated rye species, S. cereale.
28 Jun 2023
This is a picture about TEM NVU PVU TEM.
04 Jul 2023
TEM micrograph of a composite magnetite-polyvinyl pyrrolidone.
14 Jul 2023
A system for monitoring ware pollution using microwave resonant spectroscopy, the frequency of the resonant peak of absorption is highly sensitive to the composition of the water, thus allowing for detection in real-time possible pollution.
11 Aug 2023
Deformed Wing Virus (DWV) is a highly prevalent and economically significant virus that affects honeybees (Apis mellifera) worldwide. It belongs to the family Iflaviridae and is classified within the genus Iflavirus. DWV is associated with various deformities in honeybee development, particularly deformities in the wings of infected bees, hence its name.
iNaturalist
11 May 2024
SEM micrograph of diatomite
19 Jul 2023
(A) Utilizing Boronic Acid-Decorated Polymers for Intracellular Protein Delivery with Polyphenols. Polyphenols play a critical role in enhancing the interaction between polymers containing boronic acid and proteins. In an acidic environment, the pH-responsive catechol–boronate bonds form between the boronic acid-conjugated polymers and polyphenols, enabling the controlled release of RNase. This release can induce cell death by selectively targeting and degrading specific RNA molecules [1].
(B) Enhancing Chemodynamic Therapy (CDT) through the DOX−Den Complex with TA−Fe3+ MPN. The DOX−Den complex efficiently transports doxorubicin (DOX) into cancer cells while evading drug efflux transporters on the cell membrane. Within the cells, DOX is transported to the cell nuclei through the Fenton reaction-mediated CDT. This process leads to the generation of an excess of reactive oxygen species (ROS), ultimately resulting in the elimination of drug-resistant cancer cells [1].
(C) Combining Immune Checkpoint Blockade and Photodynamic Therapy using MMP-2-Sensitive PEGylated EGCG Dimers. PEGylated EGCG dimers and EGCG dimers are utilized to facilitate a novel approach that combines immune checkpoint blockade with photodynamic therapy. Upon activation by MMP-2, the nanoparticles release αPD-L1/ICG, with the antibody effectively blocking the PD-L1 checkpoint. Simultaneously, illumination of the photosensitizer induces multiple effects, including the generation of reactive oxygen species (ROS) and cell death. This innovative approach holds promise for cancer treatment [1].
08 Sep 2023
Traditional olive orchard of Galega cultivar upgraded with irrigation and spontaneous cover crop in Southern Portugal.
31 Aug 2023
Replication of the poxvirus involves several stages. [1] The virus first binds to a receptor on the host cell surface; the receptors for the poxvirus are thought to be glycosaminoglycans.
Virus entry:- Extracellular virions can enter by macropinocytosis or by direct entry at the cell surface. Host receptors are unknown. Macropinocytosis can involve apoptotic mimicry
Transcription in cytoplasmic factories- early: Viral replication machinery, host-modulating factors, core-associated enzymes and extracellular virion membrane proteins (about 118 genes in vaccinia virus)- Postreplicative events: - Intermediate:DNA binding/packaging and core-associated nonenzymatic proteins (53 Genes in vaccinia virus) - late: redox disulfide bond enzymes, virion morphogenesis, crescent formation proteins, mature virion membrane proteins and components of the entry-fusion complex (38 genes in vaccinia virus)
Virion assembly
Virus exit - by budding of Enveloped virion (EV), supported by Actin-dependent outward viral transport - by cell lysis, releasing mature virions (MV).
ViralZone, SIB Swiss Institute of Bioinformatics
22 Jan 2024
A highland cow was grazing on the grass. The Highland (Scottish Gaelic: Bò Ghàidhealach; Scots: Hielan coo) is a Scottish breed of rustic beef cattle. Highland cattle are the oldest registered breed of cattle with a Herd Book being published in 1885. Highland cattle may be red, black, yellow, white, brindle, silver, or dun color.
Jessie Wu
20 Mar 2023
Nivolumab is an anti-PD-1 monoclonal antibody acting to activate T-lymphocyte-mediated anti-tumor activity by blocking the PD-1-PD-L1 T-cell regulation pathway. Tumor-secreted cytokines recruit myeloid-derived suppressor cells, which cause immunosuppression to counteract the effects of nivolumab. Pro-angiogenic factors secreted by myeloid-derived suppressor cells stimulate angiogenesis and subsequent tumor growth. These contribute to mechanisms of resistance.
Abbreviations: ICI, Immune checkpoint inhibitor; PD-1, programmed cell death protein-1; PD-L1, programmed death-ligand 1; IL-10, interleukin-10.
23 Oct 2023
Gold nanoplatelets obtained by applying the Ostwald ripening (150°C, 3h) to gold clusters dispersed in molten polymer (polystyrene).
14 Jul 2023
Tasmanian Devil (Sarcophilus harrisii ）has a coat of coarse brown or dark fur, with a large white stripe across its breast and the odd spot on its sides. It has long front legs and shorter rear legs. Tasmanian Devil is the largest carnivorous marsupial in the world. When threatened, this marsupial bares its sharp teeth, lunges and snarls.
Jessie Wu
23 Feb 2023
The Arc de Triomphe in Paris is the largest of more than 100 Arc de Triomphe in Europe and one of the four representative buildings of the city of Paris (i.e. Eiffel Tower, Arc de Triomphe, Louvre Museum, Notre Dame). The sculpture and the huge reliefs on the arches are so beautiful that it feels like not only an old building but also a beautiful and moving work of art.
Jessie Wu
13 Feb 2023
In figure: (a) XRD pattern, (b) electron diffraction pattern, (c) TEM image, (d) size distributionhistogram of nickel ferrite particles synthesized by co-precipitation in the solution containing 0.2Ni(NO3)2 + 0.4Fe(NO3)3 + 0.01 cetrimonium bromide (CTAB) + 2 × 10−3 mol/L tartaric acid + 1 mol/L NaOH up to pH = 10 at 25℃ for 5 min.
04 Jul 2023
Scanning electron microscopy (SEM) micrograph of graphite bisulfate.
06 Dec 2023
