This graphically simplified representation outlines different approaches for the synthesis of Polyphenol-based nanoparticles (NPs) used in various medical applications[1]:
(A) Enhanced intracellular protein delivery is achieved by complexing RNase A and polyphenols through Schiff's base reactions, followed by a secondary complexation with boronic acid polymers through reactions between boronic acids and diol-based molecules.
(B) Hydrophobic drugs are non-covalently bonded to tannic acid (TA).
(C) MMP-2-sensitive S-αPDL1/ICG nanoparticles are created by complexing αPDL1 with the photosensitizer ICG, stabilizing it with dEGCG, and compressing it with PEGylated EGCG dimer.
(D) Polyphenol-coated mesoporous silica nanoparticles (MSNs) loaded with doxorubicin (DOX) are developed for targeted cancer treatment. EGCG-modified MSNs are used for drug delivery, with DOX loaded into the MSNs through noncovalent adsorption. An amine-terminated DNA aptamer ensures physiological stability and controlled drug release.
(E) Den−DOX−TA−Fe3+ (DDTF) nanocomplexes are fabricated for delivering DOX to the nuclei by coating the DOX−Den complex with TA−Fe3+ metal–polyphenol networks.
- Wahnou, H.; Liagre, B.; Sol, V.; El Attar, H.; Attar, R.; Oudghiri, M.; Duval, R.E.; Limami, Y. Polyphenol-Based Nanoparticles: A Promising Frontier for Enhanced Colorectal Cancer Treatment. Cancers 2023, 15, 3826. https://doi.org/10.3390/cancers15153826