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HandWiki is the world's largest wiki-style encyclopedia dedicated to science, technology and computing. It allows you to create and edit articles as long as you have external citations and login account. In addition, this is a content management environment that can be used for collaborative editing of original scholarly content, such as books, manuals, monographs and tutorials.

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Benzodiazepine Overdose
Benzodiazepine overdose describes the ingestion of one of the drugs in the benzodiazepine class in quantities greater than are recommended or generally practiced. The most common symptoms of overdose include central nervous system (CNS) depression, impaired balance, ataxia, and slurred speech. Severe symptoms include coma and respiratory depression. Supportive care is the mainstay of treatment of benzodiazepine overdose. There is an antidote, flumazenil, but its use is controversial. Deaths from single-drug benzodiazepine overdoses occur infrequently, particularly after the point of hospital admission. However, combinations of high doses of benzodiazepines with alcohol, barbiturates, opioids or tricyclic antidepressants are particularly dangerous, and may lead to severe complications such as coma or death. In 2013, benzodiazepines were involved in 31% of the estimated 22,767 deaths from prescription drug overdose in the United States. The US Food and Drug Administration (FDA) has subsequently issued a black box warning regarding concurrent use of benzodiazepines and opioids. Benzodiazepines are one of the most highly prescribed classes of drugs, and they are commonly used in self-poisoning. Over 10 years in the United Kingdom, 1512 fatal poisonings have been attributed to benzodiazepines with or without alcohol. Temazepam was shown to be more toxic than the majority of benzodiazepines. An Australian (1995) study found oxazepam less toxic and less sedative, and temazepam more toxic and more sedative, than most benzodiazepines in overdose.
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Topic Review
Panama Papers (North America)
The Panama Papers are 11.5 million leaked documents that detail financial and attorney–client information for more than 214,488 offshore entities. The documents, some dating back to the 1970s, were created by, and taken from, Panamanian law firm and corporate service provider Mossack Fonseca, and were leaked in 2015 by an anonymous source. This page details related allegations, reactions, and investigations, in North America.
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Topic Review
Quasi-Constitutionality
In Canada, the term quasi-constitutional is used for laws which remain paramount even when subsequent statutes, which contradict them, are enacted by the same legislature. This is the reverse of the normal practice, under which newer laws trump any contradictory provisions in any older statute.
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Topic Review
Stress-Related Disorders
Stress-related disorders can include mental health disorders that are a result of an atypical response to both short and long-term anxiety due to physical, mental, or emotional stress. These disorders can include, but are not limited to obsessive-compulsive disorder and posttraumatic stress disorder. Stress is a conscious or unconscious psychological feeling or physical condition resulting from physical or mental 'positive or negative pressure' that overwhelms adaptive capacities. It is a psychological process initiated by events that threaten, harm or challenge an organism or that exceed available coping resources and it is characterized by psychological responses that are directed towards adaptation. Stress is wear and tear on the body in response to stressful agents. Hans Selye called such agents stressors and said they could be physical, physiological, psychological or sociocultural. And stress is not an anxiety disorder and it is not a normative concept. A person typically is stressed when positive or negative (e.g., threatening) experiences temporarily strain or overwhelm adaptive capacities. Stress is highly individualized and depends on variables such as the novelty, rate, intensity, duration, or personal interpretation of the input, and genetic or experiential factors. Both acute and chronic stress can intensify morbidity from anxiety disorders. One person's fun may be another person's stressor. For an example, panic attacks are more frequent when the predisposed person is exposed to stressors.
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Topic Review
Beta-Carotene
β-Carotene is an organic, strongly coloured red-orange pigment abundant in fungi, plants, and fruits. It is a member of the carotenes, which are terpenoids (isoprenoids), synthesized biochemically from eight isoprene units and thus having 40 carbons. Among the carotenes, β-carotene is distinguished by having beta-rings at both ends of the molecule. β-Carotene is biosynthesized from geranylgeranyl pyrophosphate. In some Mucoralean fungi, β-Carotene is a precursor to the synthesis of trisporic acid. β-Carotene is the most common form of carotene in plants. When used as a food coloring, it has the E number E160a.:119 The structure was deduced by Karrer et al. in 1930. In nature, β-carotene is a precursor (inactive form) to vitamin A via the action of beta-carotene 15,15'-monooxygenase. Isolation of β-carotene from fruits abundant in carotenoids is commonly done using column chromatography. It can also be extracted from the beta-carotene rich algae, Dunaliella salina. The separation of β-carotene from the mixture of other carotenoids is based on the polarity of a compound. β-Carotene is a non-polar compound, so it is separated with a non-polar solvent such as hexane. Being highly conjugated, it is deeply colored, and as a hydrocarbon lacking functional groups, it is very lipophilic.
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Topic Review
Jury Nullification
Jury nullification is a concept where members of a trial jury find a defendant not guilty if they do not support a government's law, do not believe it is constitutional or humane, or do not support a possible punishment for breaking the law. This may happen in both civil and criminal trials. In a criminal trial, a jury nullifies by acquitting a defendant, even though the members of the jury may believe that the defendant did commit the alleged crime. This may occur when members of the jury disagree with the law the defendant has been charged with breaking, or believe that the law should not be applied in that particular case. A jury can similarly convict a defendant on the ground of disagreement with an existing law, even if no law is broken (although in jurisdictions with double jeopardy rules, a conviction can be overturned on appeal, but an acquittal cannot). A jury verdict that is contrary to the letter of the law pertains only to the particular case before it. If a pattern of acquittals develops, however, in response to repeated attempts to prosecute a statutory offence, this can have the de facto effect of invalidating the statute. A pattern of jury nullification may indicate public opposition to an unwanted legislative enactment. In the past, it was feared that a single judge or panel of government officials might be unduly influenced to follow established legal practice, even when that practice had drifted from its origins. In most modern Western legal systems, however, judges often instruct juries to act only as "finders of facts", whose role it is to determine the veracity of the evidence presented, the weight accorded to the evidence, to apply that evidence to the law as explained by the judge, and to reach a verdict; but not to question the law or decide what it says. Similarly, juries are routinely cautioned by courts and some attorneys not to allow sympathy for a party or other affected persons to compromise the fair and dispassionate evaluation of evidence. These instructions are criticized by advocates of jury nullification. Some commonly cited historical examples of jury nullification involve jurors refusing to convict persons accused of violating the Fugitive Slave Act by assisting runaway slaves or being fugitive slaves themselves, and refusal of American colonial juries to convict a defendant under English law. Juries have also refused to convict due to the perceived injustice of a law in general, or of the way the law is applied in particular cases. There have also been cases where the jury has refused to convict due to their own prejudices (for example, about the race of one of the parties in the case).
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Topic Review
Nanopore Sequencing
Nanopore sequencing is a third generation approach used in the sequencing of biopolymers — specifically, polynucleotides in the form of DNA or RNA. Using nanopore sequencing, a single molecule of DNA or RNA can be sequenced without the need for PCR amplification or chemical labeling of the sample. Nanopore sequencing has the potential to offer relatively low-cost genotyping, high mobility for testing, and rapid processing of samples with the ability to display results in real-time. Publications on the method outline its use in rapid identification of viral pathogens, monitoring ebola, environmental monitoring, food safety monitoring, human genome sequencing, plant genome sequencing, monitoring of antibiotic resistance, haplotyping and other applications.
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Aorun
Aorun (pron.:"AW-roon") is an extinct genus of carnivorous theropod dinosaur first discovered in 2006, with its scientific description published in 2013. It is one of the oldest known coelurosaurian dinosaurs and is estimated to have lived ~161.6 million years ago during the Late Jurassic Period. It is the fifth theropod discovered from Wucaiwan.
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Topic Review
Woodward Effect
The Woodward effect, also referred to as a Mach effect, is part of a hypothesis proposed by James F. Woodward in 1990. The hypothesis states that transient mass fluctuations arise in any object that absorbs internal energy while undergoing a proper acceleration. Harnessing this effect could generate a reactionless thrust, which Woodward and others claim to measure in various experiments. Hypothetically, the Woodward effect would allow for field propulsion spacecraft engines that would not have to expel matter. Such a proposed engine is sometimes called a Mach effect thruster (MET) or a Mach Effect Gravitational Assist (MEGA) drive. So far, experimental results have not strongly supported this hypothesis, but experimental research on this effect, and its potential applications, continues. The Space Studies Institute was selected as part of NASA's Innovative Advanced Concepts program as a Phase I proposal in April 2017 for Mach Effect research. The year after, NASA awarded a NIAC Phase II grant to the SSI to further develop these propellantless thrusters. The effect is controversial within mainstream physics because the underlying model proposed for it appears to be faulty, resulting in violations of energy conservation as well as momentum conservation.
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Topic Review
AIM
AIM (AOL Instant Messenger) was an instant messaging and presence computer program created by AOL, which used the proprietary OSCAR instant messaging protocol and the TOC protocol to allow registered users to communicate in real time. AIM was popular by the late 1990s, in United States and other countries, and was the leading instant messaging application in that region into the following decade. Teens and college students were known to use the messenger's away message feature to keep in touch with friends, often frequently changing their away message throughout a day or leaving a message up with one's computer left on to inform buddies of their ongoings, location, parties, thoughts, or jokes. AIM's popularity declined as AOL subscribers started decreasing and steeply towards the 2010s, as Gmail's Google Talk, SMS, and Internet social networks, like Facebook gained popularity. Its fall has often been compared with other once-popular Internet services, such as Myspace. In June 2015, AOL was acquired by Verizon Communications. In June 2017, Verizon combined AOL and Yahoo into its subsidiary Oath Inc. (now called Yahoo). The company discontinued AIM as a service on December 15, 2017.
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