Summary

On 11 March 2020, the World Health Organization declared COVID-19 a global pandemic, and the disease now affects nearly every country and region. Caused by SARS-CoV-2, COVID-19 continues nearly 18 months later to present significant challenges to health systems and public health in both hemispheres, as well as the economies of every country. The morbidity and mortality of the infection caused by SARS-CoV-2 has been significant, and various waves of disease outbreaks initially overwhelmed many hospitals and clinics and continue to do so in many countries. This influences everyone, and public health countermeasures have been dramatic in terms of their impact on employment, social systems, and mental health. This entry collection aims to gather diverse fields about COVID-19, including in epidemiology, public health, medicine, genetics, systems biology, informatics, data science, engineering, sociology, anthropology, nursing, environmental studies, statistics, and psychology.

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Entries
Topic Review
Ukrainian Migrants in Poland during COVID-19 Pandemic
Economic and political crises have significant impacts on the situation of foreigners in their host country. Some of these impacts of such crises can be predicted, while others appear unexpectedly. Particularly challenging are those characterised by extreme unusualness and the absence of warning signs that suggest the possibility of their occurrence. The pandemic as an emergency situation entailing restrictions on mobility between countries did not significantly affect the migration decisions of Ukrainians. Disregarding the difficult epidemiological situation, they continued to make decisions on immigration to Poland, guided by individual profit and loss calculations. Others remained in Poland to wait out the crisis. The pandemic has exposed the dependence of the Polish economy on migrant labour and has also shown the deficiencies in migration policy.
  • 488
  • 23 May 2022
Topic Review
Human Coronavirus
Coronaviruses (CoVs) are a large group of viruses common among many animals, including humans. They can cause respiratory illnesses in humans and gastrointestinal illnesses in animals. Under the electron microscope, virions of CoVs have large peplomers that make it look like a crown, hence the name corona, meaning “crown” or “halo. The emerging coronavirus disease (COVID-19) swept across the world, affecting more than 200 countries and territories.
  • 578
  • 20 May 2022
Topic Review
New-Onset Acute Kidney Disease Post COVID-19 Vaccination
The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused an exceptional setback to the global economy and health. Vaccination is one of the most effective interventions to markedly decrease severe illness and death from COVID-19. Acute kidney disease (AKD) is defined as a condition of acute or subacute damage and/or loss of renal function between 7 and 90 days after exposure to an AKI initiating event
  • 627
  • 23 May 2022
Topic Review
Selenoproteins in SAR-CoV-2 Infection
The SARS-CoV-2 infection is a highly contagious viral infection, which has claimed millions of lives in the last two years. The infection can cause acute respiratory distress, myocarditis, and systemic inflammatory response in severe cases. The interaction of the viral spike protein with the angiotensin-converting enzyme in various tissues causes damage to vital organs and tissues, leading to complications in the post-infection period. Investigations are now focused on supportive nutrient therapies, which can mitigate the susceptibility as well as the long-term complications of COVID-19. Selenium is one such micronutrient that plays a vital role in preventing oxidative stress induced by the virus.
  • 415
  • 19 May 2022
Topic Review
Different Biomedical Cell Products in COVID-19 Treatment
SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is a single-stranded RNA virus, infectious agent of coronavirus disease 2019 (COVID-19). COVID-19 is a real challenge for the protective immunity. Some people do not respond to vaccination by acquiring an appropriate immunological memory. The risk groups for this particular infection such as the elderly and people with compromised immunity (cancer patients, pregnant women, etc.) have the most serious problems in developing an adequate immune response. Therefore, dendritic cell (DC) vaccines that are loaded ex vivo with SARS-CoV-2 antigens in the optimal conditions are promising for immunization. Lymphocyte effector cells with chimeric antigen receptor (CAR-lymphocytes) are currently used mainly as anti-tumor treatment. However, CAR-lymphocytes may be successfully employed to treat viral diseases including COVID-19. Allogenic anti-SARS-CoV-2 CAR-NK-cells may be used as an emergency treatment.
  • 358
  • 18 May 2022
Topic Review
SARS-CoV-2 Infection and Valproic Acid
The histone deacetylase inhibitor valproic acid (VPA) is a potential drug that could be adapted to prevent the progression and complications of SARS-CoV-2 infection. VPA has a history of research in the treatment of various viral infections. VPA inhibits SARS-CoV-2 virus entry, suppresses the pro-inflammatory immune cell and cytokine response to infection, and reduces inflammatory tissue and organ damage by mechanisms that may appear to be sex-related. The antithrombotic, antiplatelet, anti-inflammatory, immunomodulatory, glucose- and testosterone-lowering in blood serum effects of VPA suggest that the drug could be promising for therapy of COVID-19. Sex-related differences in the efficacy of VPA treatment may be significant in developing a personalised treatment strategy for COVID-19.
  • 465
  • 18 May 2022
Topic Review
Work-Life Balance, Job Performance and Knowledge Risks
Despite the focus on knowledge risks in the literature, a limited number of studies have empirically examined technological knowledge risks in terms of digitalization, old technologies, and cybercrime as moderating variables in the relationship between work-life balance and job performance. To address this gap, this entry investigated the moderation effects of technological knowledge risks on the relationship between work-life balance and job performance during the pandemic period in employees of cooperative credit banks. A quantitative approach that involved gathering surveys was adopted. Applying PLS-SEM, the empirical findings revealed that technological knowledge risks have a significant impact on the relationship between work-life balance and job performance. Additionally, this research encourages managers to create and maintain a healthy work environment that promotes valuable employees’ job performance while also evaluating the use of new technological advances and their related risks.
  • 1.7K
  • 13 Jun 2022
Topic Review
Pathogenetic Analogies of Preeclampsia and COVID-19
Preeclampsia is an obstetric pathology that, surprisingly, resembles the pathology of COVID-19. Both diseases are characterized by significant alterations in the renin-angiotensin system (RAS). RAS-mediated mechanisms may explain their primary clinical-pathological features, which are suggestive of an underlying microvascular dysfunction, with induction of vasculopathy, coagulopathy, and inflammation. 
  • 552
  • 16 May 2022
Topic Review
Sulfated Polysaccharides from Seaweeds
Sulfated polysaccharides derived from seaweeds, considered a potential source of bioactive compounds for drug development, have shown antiviral activity against a broad spectrum of viruses, mainly including common DNA viruses and RNA viruses. In addition, sulfated polysaccharides can also improve the body’s immunity. Sulfated polysaccharides from seaweeds, including carrageenan, galactan, fucoidan, alginate, ulvan, p-KG03, naviculan, and calcium spirulan, may provide new ideas for the development of COVID-19 therapeutics and vaccines.
  • 840
  • 16 May 2022
Topic Review
Biological Time and Host-Virus Interaction
Living beings spend their lives and carry out their daily activities interacting with environmental situations that present space-time variations and that involve contact with other life forms, which may behave as commensals or as invaders and/or parasites. The characteristics of the environment, as well as the processes that support the maintenance of life and that characterize the execution of activities of daily life generally present periodic variations, which are mostly synchronized with the light–dark cycle determined by Earth’s rotation on its axis. These rhythms with 24-h periodicity, defined as circadian, influence events linked to the interaction between hosts and hosted microorganisms and can dramatically determine the outcome of this interplay. 
  • 508
  • 10 Nov 2022
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