Topic Review
Stem Cell-Derived Extracellular Vesicles in Systemic Lupus Erythematosus
Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease that affects nearly 3.41 million people globally, with 90% of the cases affecting women of childbearing age. Extracellular vesicles (EVs) can reduce the pro-inflammatory cytokines and increase the anti-inflammatory cytokines. Moreover, EVs can increase the levels of regulatory T cells, thus reducing inflammation. EVs also have the potential to regulate B cells to alleviate SLE and reduce its adverse effects. 
  • 379
  • 05 Mar 2024
Topic Review
Deep Learning for Alzheimer’s Disease Detection
Deep learning has become a prominent approach in Alzheimer’s disease (AD) detection using medical image data, incorporating modalities like positron emission tomography (PET) and magnetic resonance imaging (MRI). These advances in deep learning and multimodal imaging have improved AD detection accuracy and effectiveness, leveraging convolutional neural networks (CNNs), recurrent neural networks (RNNs), and generative modelling techniques. 
  • 113
  • 05 Mar 2024
Topic Review
Adjuvant Radiotherapy in the Treatment of Breast Cancer
The role of postmastectomy radiotherapy and regional nodal irradiation after radical mastectomy is defined in high-risk patients with locally advanced tumors, positive margins, and unfavorable biology. The benefit of postmastectomy radiotherapy in intermediate-risk patients (T3N0 tumors) remains a matter of controversy. It has been demonstrated that radiotherapy after breast-conserving surgery lowers the locoregional recurrence rate compared with surgery alone and improves the overall survival rate. In patients with four or more positive lymph nodes or extracapsular extension, regional lymph node irradiation is indicated regardless of the surgery type (breast-conserving surgery or mastectomy). Despite the consensus that patients with more than three positive lymph nodes should be treated with radiotherapy, there is controversy regarding the recommendations for patients with one to three involved lymph nodes. In patients with N0 disease with negative findings on axillary surgery, there is a trend to administer regional lymph node irradiation in patients with a high risk of recurrence. In patients treated with neoadjuvant systemic therapy and mastectomy, adjuvant radiotherapy should be administered in cases of clinical stage III and/or ≥ypN1. In patients treated with neoadjuvant systemic therapy and breast-conserving surgery, postoperative radiotherapy is indicated irrespective of pathological response.
  • 96
  • 05 Mar 2024
Biography
Delfim Fernando Marado Torres (Delfim F. M. Torres)
Professor Dr. Delfim F. M. Torres, D.Sc. (Habilitation) in Mathematics, Ph.D. in Mathematics, Web of Science Highly Cited Researcher (2015, 2016, 2017 and 2019). Full Professor of Mathematics (Professor Catedrático), Department of Mathematics, University of Aveiro, 3810-193 Aveiro, Portugal. Director of the R&D unit CIDMA (http://cidma.ua.pt). Coordinator of the Systems and Control Group (http:
  • 271
  • 04 Mar 2024
Topic Review
Epigenetic Implications in Glaucoma Neurodegenerative Disease
Glaucoma, a complex and multifactorial neurodegenerative disorder, is a leading cause of irreversible blindness worldwide. Despite significant advancements in the understanding of its pathogenesis and management, early diagnosis and effective treatment of glaucoma remain major clinical challenges. Epigenetic modifications, encompassing deoxyribonucleic acid (DNA) methylation, histone modifications, and non-coding RNAs, have emerged as critical regulators of gene expression and cellular processes.
  • 105
  • 04 Mar 2024
Topic Review
Wide-Bandgap Semiconductors for Radiation Detection
An overview of wide-bandgap (WBG) semiconductors for radiation detection applications is given. The recent advancements in the fabrication of high-quality wafers have enabled remarkable WBG semiconductor device applications. The most common 4H-SiC, GaN, and β-Ga2O3 devices used for radiation detection are described.
  • 226
  • 04 Mar 2024
Topic Review
Orange-Fruit Detection in a Dynamic Environment
Agricultural robots play a crucial role in ensuring the sustainability of agriculture. Fruit detection is an essential part of orange-harvesting robot design. Ripe oranges need to be detected accurately in an orchard so they can be successfully picked. Accurate fruit detection in the orchard is significantly hindered by the challenges posed by the illumination and occlusion of fruit. Hence, it is important to detect fruit in a dynamic environment based on real-time data.
  • 197
  • 04 Mar 2024
Topic Review
Lactic Acid Bacteria as an Emerging Group
Increasing awareness of the problems caused by synthetic agrochemicals, such as chemical fertilizers, pesticides, and herbicides, makes it crucial to discover substitute approaches that can guarantee competitive plant production and protect the environment while maintaining the natural balance in agroecosystems. One of the leading alternatives is utilizing rhizobacterial strains named plant growth-promoting rhizobacteria (PGPR).
  • 204
  • 04 Mar 2024
Topic Review
Lycium barbarum Deep-Processing Products of Fermentation
Lycium barbarum, a homology of medicine and food, contains many active ingredients including polysaccharides, polyphenol, betaine, and carotenoids, which has health benefits and economic value. The bioactive components in Lycium barbarum exhibit the effects of antioxidation, immune regulation, hypoglycemic effects, and vision improvement.
  • 264
  • 04 Mar 2024
Topic Review
Use of Phase Change Materials in Geopolymers
Phase change materials (PCM) were known already in the 1970s (similarly to geopolymers), but their development is observed today. This is related to the possibility of obtaining a stable phase as well as the possibility of optimization of construction materials concerning the construction needs. These materials can change their physical state depending on the ambient temperature. The most common method is liquid-solid conversion. In the area of application of phase change materials in the construction industry, examples of such materials include organic materials (paraffin, fatty acids), inorganic materials, and eutectics. 
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  • 04 Mar 2024
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