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Topic Review
Whole Genome Amplification in Preimplantation Genetic Testing
Successful whole genome amplification (WGA) is a cornerstone of contemporary preimplantation genetic testing (PGT). Choosing the most suitable WGA technique for PGT can be particularly challenging.
  • 979
  • 27 Jul 2022
Topic Review
Whole Genome Amplification and the appropriate DNA polymerases
In the same way that specialized DNA polymerases (DNAPs) replicate cellular and viral genomes, only a handful of dedicated proteins from various natural origins as well as engineered versions are appropriate for competent exponential amplification of whole genomes and metagenomes (WGA). Different applications have led to the development of diverse protocols, based on various DNAPs. Isothermal whole genomes and metagenomes (WGA) is currently widely used due to the high performance of Φ29 DNA polymerase, but polymerase chain reaction (PCR)-based methods are also available and can provide competent amplification of certain samples. Replication fidelity and processivity must be considered when selecting a suitable enzyme for WGA. However, other properties, such as thermostability, capacity to couple replication, and double helix unwinding, or the ability to maintain DNA replication opposite to damaged bases, are also very relevant for some applications.
  • 305
  • 29 Jun 2023
Topic Review
Whole Brain Radiotherapy among Lung Cancer Patients
Lung cancer is the most common cancer causing brain metastases at the time of diagnosis and brain metastases can be found in up to 50% of patients with lung cancer. Brain metastases among lung cancer patients have, in general, been associated with serious symptoms and a short survival. However, local treatments of brain metastases have been developed over time in terms of refined neuroimaging, surgery, and radiotherapy. This allows patients to receive improved treatment with prolonged benefits and fewer side effects. In addition, there have been advances in systemic oncological therapies for lung cancer patients in recent years, and systemic treatment, including chemotherapy, targeted therapy, and immunotherapy, may prevent or delay brain metastases. Determining the appropriate treatment for patients with lung cancer and brain metastases, therefore, requires a clear understanding of the brain metastases, molecular characteristics, tumor histology, and the overall lung cancer prognosis.
  • 279
  • 12 Apr 2022
Topic Review
Whole Blood Polyamine Levels in Age-Related Diseases
The relationship between polyamines and healthy longevity has received much attention. The most fundamental consideration in conducting polyamine studies is that bovine serum used for cell culture contains bovine serum amine oxidase. Bovine serum amine oxidase, which is not inactivated by heat treatment, breaks down spermine and spermidine to produce the highly toxic aldehyde acrolein, which causes cell damage and activates autophagy. Polyamine catabolism does not produce toxic aldehydes under normal conditions, but inflammation and some pathogens provoke an inducible enzyme, spermine oxidase, which only breaks down spermine to produce acrolein, resulting in cytotoxicity and the activation of autophagy. Therefore, spermine oxidase activation reduces spermine concentration and the ratio of spermine to spermidine, a feature reported in patients with age-related diseases. Spermine, which is increased by a long-term, continuous high polyamine diet, suppresses aberrant gene methylation and the pro-inflammatory status that progress with age and are strongly associated with the development of several age-related diseases and senescence. Changes in spermine concentration and the spermine/spermidine ratio should be considered as indicators of human health status.
  • 403
  • 26 Oct 2023
Topic Review
Who Killed Captain Alex?
Who Killed Captain Alex? is a 2010 Ugandan action-comedy film written, produced, and directed by Nabwana IGG, in Wakaliwood, an ultra low-budget studio in Kampala, Uganda. It has gained viral notoriety for being a no-budget action film, produced on a reported budget of under $200. A trailer for the film was uploaded to YouTube in January 2010, and has been viewed over 2.2 million times as of May 2018. The original version of the film was lost due to power outages and "strained conditions", while the surviving version of Who Killed Captain Alex? released online includes an English "Video Joker" commentary that adds in running gags about the characters.
  • 4.0K
  • 02 Oct 2022
Topic Review
WHO Critical Priority Pathogens
The rise of multidrug-resistant (MDR) pathogens has become a global health threat and an economic burden in providing adequate and effective treatment for many infections. This large-scale concern has emerged mainly due to mishandling of antibiotics (ABs) and has resulted in the rapid expansion of antimicrobial resistance (AMR). Nowadays, there is an urgent need for more potent, non-toxic and effective antimicrobial agents against MDR strains. In this regard, clinicians, pharmacists, microbiologists and the entire scientific community are encouraged to find alternative solutions in treating infectious diseases cause by these strains. In its “10 global issues to track in 2021”, the World Health Organization (WHO) has made fighting drug resistance a priority. 
  • 2.1K
  • 21 Jul 2022
Topic Review
Whiteflies
Whiteflies are a group of universally occurring phloem sap sucking insects that has secured a status of most devastating pests for causing both direct and indirect damages to crops. A few of them serve as vectors of plant viruses that are detrimental to the crop in question and cause an actual loss in productivity. A lot of attention is focused on pest control measures under the umbrella of IPM (Integrated pest management). 
  • 725
  • 12 Jul 2021
Topic Review
White–Juday Warp-Field Interferometer
The White–Juday warp-field interferometer is an experiment designed to detect a microscopic instance of a warping of spacetime. If such a warp is detected, it is hoped that more research into creating an Alcubierre warp bubble will be inspired. A research team led by Harold "Sonny" White in collaboration with Dr. Richard Juday at the NASA Johnson Space Center and Dakota State University are conducting experiments, but results so far have been inconclusive.
  • 2.6K
  • 24 Nov 2022
Topic Review
White-tailed Mongoose
The White-tailed Mongoose (Ichneumia albicauda) is a captivating carnivorous mammal native to the African continent, distinguished by its striking white-tipped tail and sleek, slender physique. Inhabiting a variety of habitats, from woodlands to grasslands, this elusive mongoose species plays a vital role in the ecosystems it calls home.
  • 303
  • 04 Feb 2024
Topic Review
White-Tailed Deer Population Density and Tick-Borne Disease Risk
Spatial distributions between deer population density and human and canine tick-borne diseases (TBDs) in northeastern and southern Indiana, which are rural and mixed geographic areas. Overall, Lyme disease is more prevalent in the northwest, central-western, and southeastern counties, while ehrlichiosis is more common in the southern counties. These findings hold true across humans, canines, and deer.
  • 307
  • 28 Nov 2023
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