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Topic Review
Monoclonal Antibodies for Targeted Fluorescence-Guided Surgery
Due to their specificity, monoclonal antibodies have significantly impacted cancer patients’ care, becoming one of the fastest-growing classes of new drugs approved for the treatment of solid tumors. Targeted fluorescence-guided surgery is a novel technology to better visualize tumor residuals intraoperatively. It consists of a fluorescent molecular probe, that, once injected, lights up the neoplastic cells during the surgical resection. In this regard, the development of an off-the-shelf large-scale production of clinically approved, fluorescently labeled monoclonal antibodies for targeted fluorescence-guided surgery is becoming an urgent need for oncological surgeons working in this field.
  • 133
  • 15 Mar 2024
Topic Review
South American Gray Fox
The South American Gray Fox, scientifically known as Lycalopex griseus, is a captivating canid species native to South America. Renowned for its sleek gray fur and bushy tail, this fox inhabits a variety of habitats, from grasslands and scrublands to forests and urban areas. As an adaptable omnivore, the South American Gray Fox plays a crucial role in its ecosystem by regulating prey populations and participating in seed dispersal, contributing to the overall balance of its environment.
  • 339
  • 15 Mar 2024
Topic Review
Pathophysiology of Secondary Acute Myeloid Leukemia
Secondary acute myeloid leukemia (sAML) is a heterogeneous malignant hematopoietic disease that arises either from an antecedent hematologic disorder (AHD) including myelodysplastic syndromes (MDS), myeloproliferative neoplasms (MPN), aplastic anemia (AA), or as a result of exposure to genotoxic chemotherapeutic agents or radiotherapy (therapy related AML, tAML). sAML is diagnosed when the number of blasts is ≥20% in the bone marrow or peripheral blood, and it is characterized by poor prognosis, resistance to therapy and low overall survival rate. 
  • 132
  • 15 Mar 2024
Topic Review
Endoscopic Spine Surgery
The origins of endoscopic spine surgery can be traced back many decades, with many important innovations throughout its development. It can be applied to all levels of the spine, with many robust trials supporting its clinical outcomes. Continued clinical research is needed to explore its expanding indications.
  • 80
  • 15 Mar 2024
Topic Review
Pavo
Pavo, Latin for "peacock," is a small but distinct constellation in the southern sky. Representing the majestic bird from ancient mythology, Pavo is notable for its compact arrangement of stars and its proximity to the south celestial pole, making it a prominent feature of the southern hemisphere's night sky.
  • 206
  • 15 Mar 2024
Topic Review
Common Genet
The Common Genet, also known as Genetta genetta, is a small carnivorous mammal native to Europe and parts of North Africa. Recognizable by its slender body, long tail, and distinctive facial markings, the Common Genet is a nocturnal hunter, preying on small mammals, birds, reptiles, and insects. Despite its name, the Common Genet is not closely related to cats but belongs to the family Viverridae, making it a unique and intriguing member of the carnivore community.
  • 241
  • 15 Mar 2024
Topic Review
Antarctic Fur Seal
The Antarctic Fur Seal, scientifically known as Arctocephalus gazella, is a charismatic marine mammal native to the subantarctic and Antarctic regions. Recognized for its dense fur coat, robust build, and distinctive facial features, this species is a top predator in its icy habitat. Antarctic Fur Seals play a vital role in marine ecosystems, influencing prey populations and contributing to the overall health of polar environments.
  • 280
  • 15 Mar 2024
Topic Review
Galapagos Fur Seal
The Galapagos Fur Seal, scientifically known as Arctocephalus galapagoensis, is a marine mammal endemic to the Galapagos Islands. With its dense, dark brown fur and slender physique, this species is well-adapted to its coastal habitat. Despite its name, the Galapagos Fur Seal is not a true seal but rather belongs to the fur seal family, Otariidae, distinguishing it by its ability to rotate its hind flippers forward for efficient movement on land.
  • 311
  • 15 Mar 2024
Topic Review
Orion
Orion, one of the most recognizable constellations in the night sky, is steeped in mythology and astronomical significance. Named after the legendary hunter from Greek mythology, Orion is adorned with bright stars, including the famous Orion's Belt, and hosts a plethora of celestial wonders, such as the Orion Nebula, making it a favorite among stargazers.
  • 431
  • 15 Mar 2024
Topic Review
Glypican-Regulated Transport and Gradient Formation in Drosophila
Glypicans (Glps) are a family of heparan sulphate proteoglycans that are attached to the outer plasma membrane leaflet of the producing cell by a glycosylphosphatidylinositol anchor. Glps are involved in the regulation of many signalling pathways, including those that regulate the activities of Wnts, Hedgehog (Hh), Fibroblast Growth Factors (FGFs), and Bone Morphogenetic Proteins (BMPs), among others. In the Hh-signalling pathway, Glps have been shown to be essential for ligand transport and the formation of Hh gradients over long distances, for the maintenance of Hh levels in the extracellular matrix, and for unimpaired ligand reception in distant recipient cells. 
  • 95
  • 15 Mar 2024
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