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Topic Review
2020–2021 Taal Volcano Eruptions
Taal Volcano in Batangas, Philippines began to erupt on January 12, 2020, when a phreatomagmatic eruption from its main crater spewed ashes over Calabarzon, Metro Manila, and some parts of Central Luzon and Ilocos Region, resulting in the suspension of school classes, work schedules, and flights in the area. The Philippine Institute of Volcanology and Seismology (PHIVOLCS) subsequently issued an Alert Level 4, indicating "that a hazardous explosive eruption is possible within hours to days." Volcanic activity continued into 2021, when smaller eruptions occurred in July 2021.
  • 5.4K
  • 24 Nov 2022
Topic Review
2021 Columbia University Strike
The 2021 Columbia University strike was a labor strike involving graduate students at Columbia University in New York City . The strike, which began on March 15, 2021, was organized by the Graduate Workers of Columbia–United Auto Workers Local 2110, a labor union representing student workers at the university. This union was formed in December 2016 and has had a contentious relationship with the university since its founding, with the university only agreeing to recognize the union in 2019. That same year, the union and university began to negotiate a labor contract, but disagreements between the two entities have prevented an agreement from being made. The main issue concerns union recognition, with the university recognizing only fully-funded doctoral students as union members, while the union also recognizes master's students and undergraduate teaching assistants as members. Additional issues include disagreements over health benefits and child care, among others. While the union voted in March 2020 to authorize strike action, these plans were postponed due to the COVID-19 pandemic. However, in February 2021, still without a labor contract, the union announced their intent to strike the following month. The strike began on March 15 as an open-ended strike action, with no set end date. The strike coincided with a tuition strike that had been coordinated by the local chapter of the Young Democratic Socialists of America. Picketing and other forms of protest were held at numerous Columbia locations throughout New York City, and multiple elected officials and politicians announced their support for the strikers. On April 19, a contract proposal was submitted for ratification by the union members, but it was rejected in a rank-and-file vote. Following this, a vote was held in early May to determine the future of the strike, with a majority of voters choosing to end the strike, which officially ended on May 13. Following the end of the strike, on July 3, new leaders for the union were elected who promised to continue to push for a labor contract with the university. Additionally, the name of the union was changed to the Student Workers of Columbia. While negotiations were set to resume on August 25, a disagreement between who should be allowed to attend the meeting caused an impasse, with Columbia pushing for a closed-door meeting with a limited number of attendees and the union wanting the negotiations open to all members. On September 15, the union initiated another strike authorization vote and filed an unfair labor practice charge against the university.
  • 940
  • 15 Nov 2022
Topic Review
2021 Peptides and Oligonucleotides Harvest
From the medical, pharmaceutical, and social perspectives, 2021 has been a year dominated by the COVID-19 pandemic. However, despite this global health crisis, the pharmaceutical industry has continued its endeavors, and 2021 could be considered an excellent year in terms of the drugs accepted by the US Food and Drug Administration (FDA). Thus, during this year, the FDA has approved 50 novel drugs, of which 36 are new chemical entities and 14 biologics. It has also authorized 10 TIDES (8 peptides, 2 oligonucleotides), in addition to 2 antibody-drug conjugates (ADCs) whose structures contain peptides.
  • 1.2K
  • 17 Feb 2022
Topic Review
21-hydroxylase deficiency
21-hydroxylase deficiency is an inherited disorder that affects the adrenal glands. The adrenal glands are located on top of the kidneys and produce a variety of hormones that regulate many essential functions in the body. In people with 21-hydroxylase deficiency, the adrenal glands produce excess androgens, which are male sex hormones.
  • 523
  • 23 Dec 2020
Topic Review
21st Century Skills and Mobile-Technology-Supported Inquiry-Based Learning
The development of 21st-century skills is paramount. Among these skills, which encompass collaboration, communication, critical thinking, and creativity, Mobile-Technology-Supported Inquiry-Based Learning (mIBL) in Science Education emerges as a potent method for their enhancement.
  • 1.6K
  • 14 Nov 2023
Topic Review
22 Short Films About Springfield
Template:Infobox Simpsons episode "22 Short Films About Springfield" is the twenty-first episode of The Simpsons' seventh season. It originally aired on the Fox network in the United States on April 14, 1996. It was written by Richard Appel, David S. Cohen, Jonathan Collier, Jennifer Crittenden, Greg Daniels, Brent Forrester, Dan Greaney, Rachel Pulido, Steve Tompkins, Josh Weinstein, Bill Oakley, and Matt Groening, with the writing being supervised by Daniels. The episode was directed by Jim Reardon. Phil Hartman guest starred as Lionel Hutz and the hospital board chairman. The episode depicts brief incidents experienced by a wide array of Springfield residents in a series of interconnected stories that take place over a single day. The episode's concept originated from the end segment of the season four episode "The Front", and serves as a loose parody of Pulp Fiction, which gave the staff the idea of a possible spin-off from The Simpsons. The title is a reference to the film Thirty Two Short Films About Glenn Gould. The episode received positive reviews from critics, and is noted for its popularity among fans.
  • 772
  • 16 Nov 2022
Topic Review
22q11.2 Deletion Syndrome
22q11.2 deletion syndrome (which is also known by several other names, listed below) is a disorder caused by the deletion of a small piece of chromosome 22. The deletion occurs near the middle of the chromosome at a location designated q11.2.  
  • 500
  • 23 Dec 2020
Topic Review
22q11.2 Microdeletion
Chromosomal 22q11.2 deletion syndrome (22q11.2DS) (ORPHA:567) caused by microdeletion in chromosome 22 is the most common chromosomal microdeletion disorder in humans. Despite the same change on the genome level like in case of monozygotic twins, phenotypes are expressed differently in 22q11.2 deletion individuals. The rest of the genome, as well as epigenome and environmental factors, are not without influence on the variability in phenotypes. The penetrance seems to be more genotype-specific than deleted locus-specific. The transcript levels of deleted genes are not usually reduced by 50% as assumed due to haploinsufficiency. 22q11.2DS is often undiagnosed condition, as each patient may have a different set out of 180 possible clinical manifestations. Diverse dysmorphic traits are present in patients from different ethnicities, which makes diagnosis even more difficult. 22q11.2 deletion syndrome serve as an example of genetic syndrome that is not easy to manage at all stages: diagnosis, consulting and dealing with.
  • 675
  • 08 Sep 2020
Topic Review
22q13.3 Deletion Syndrome
22q13.3 deletion syndrome, which is also known as Phelan-McDermid syndrome, is a disorder caused by the loss of a small piece of chromosome 22. The deletion occurs near the end of the chromosome at a location designated q13.3.  
  • 543
  • 25 Dec 2020
Topic Review
25-Hydroxycholesterol Effect on Membrane Properties
Cholesterol is responsible for the plasticity of plasma membranes and is involved in physiological and pathophysiological responses. Cholesterol homeostasis is regulated by oxysterols, such as 25-hydroxycholesterol. The presence of 25-hydroxycholesterol at the membrane level has been shown to interfere with several viruses’ entry into their target cells. We used atomic force microscopy to assess the effect of 25-hydroxycholesterol on different properties of supported lipid bilayers with controlled lipid compositions. In particular, we showed that 25-hydroxycholesterol inhibits the lipid-condensing effects of cholesterol, rendering the bilayers less rigid. This study indicates that the inclusion of 25-hydroxycholesterol in plasma membranes or the conversion of part of their cholesterol content into 25-hydroxycholesterol leads to morphological alterations of the sphingomyelin (SM)-enriched domains and promotes lipid packing inhomogeneities. These changes culminate in membrane stiffness variations.
  • 478
  • 17 Mar 2021
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