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Topic Review
2-hydroxyglutaric aciduria
2-hydroxyglutaric aciduria is a condition that causes progressive damage to the brain. The major types of this disorder are called D-2-hydroxyglutaric aciduria (D-2-HGA), L-2-hydroxyglutaric aciduria (L-2-HGA), and combined D,L-2-hydroxyglutaric aciduria (D,L-2-HGA).
  • 478
  • 23 Dec 2020
Topic Review
2-Hydroxymelatonin
2-OHM treatment induced ROS production in arabidopsis, whereas melatonin did not. ROS production by 2-OHM treatment occurred in old arabidopsis leaves in darkness, consistent with an ethylene-mediated senescence mechanism. Transgenic tobacco plants containing overexpressed rice M2H exhibited dwarfism and leaf necrosis of the upper leaves and early senescence of the lower leaves. We also demonstrated that 2-OHM-mediated ROS production is respiratory burst NADPH oxidase (RBOH)-dependent and that 2-OHM-induced senescence genes require ethylene and the abscisic acid (ABA) signaling pathway in arabidopsis. In contrast to melatonin, 2-OHM treatment induced senescence symptoms such as leaf chlorosis and increased ion leakage in arabidopsis. Senescence induction is known to begin with decreased levels of proteins involved in chloroplast maintenance including Lhcb1 and ClpR1. Together, these results show that 2-OHM acts as a senescence-inducing factor by inducing ROS production in plants
  • 557
  • 29 Mar 2022
Topic Review
2-Oxocarboxylic Acids
Atmospheric organic aerosols play a major role in climate, demanding a better understanding of their formation mechanisms by contributing multiphase chemical reactions with the participation of water. The sunlight driven aqueous photochemistry of small 2-oxocarboxylic acids is a potential major source of organic aerosol, which prompted the investigations into the mechanisms of glyoxylic acid and pyruvic acid photochemistry reviewed here. While 2-oxocarboxylic acids can be contained or directly created in the particles, the majorities of these abundant and available molecules are in the gas phase and must first undergo the surface uptake process to react in, and on the surface, of aqueous particles.
  • 1.1K
  • 02 Jul 2023
Topic Review
2-Phenylethanol
2-Phenylethanol (2-PE), also known as 2-phenethyl alcohol, is a higher aromatic alcohol characterized by one of the most popular and desired fragrances, which is the rosy scent.
  • 1.8K
  • 13 Jan 2022
Topic Review
2-Substituted Benzimidazoles as Photo-Protective Agents
The modern trend in sunscreen products is towards the development of UV filters with multi-functional properties, to provide a broad shielding against ultraviolet radiation, antioxidant activity, and the prevention of skin cancer. Additionally, they should also be safe for humans as well as the environment. The benzimidazole heterocycle is a suitable platform for the development of such multifunctional molecules with potential application in cosmetic formulations, due to their ability to act as both UV protectors and reactive pharmacophores. 
  • 239
  • 16 Dec 2023
Topic Review
2,7(3,6)-Diaryl(arylamino)-substituted Carbazoles
The carbazole is an electron-rich heterocyclic compound, whose structure can be easily modified by rather simple reactions in order to obtain 2,7(3,6)-diaryl(arylamino)-substituted carbazoles. The substituted derivatives are widely used for the formation of Organic light emitting diode (OLED) due to their good charge carrier injection and transfer characteristics, electroluminescence, thermally activated delayed fluorescence, improved thermal and morphological stability as well as their thin film forming characteristics. 
  • 1.0K
  • 24 Nov 2021
Topic Review
2.5D Multi-Objective Path Planning for Ground Vehicles
Due to the vastly different energy consumption between up-slope and down-slope, a path with the shortest length in a complex off-road terrain environment (2.5D map) is not always the path with the least energy consumption. For any energy-sensitive vehicle, realizing a good trade-off between distance and energy consumption in 2.5D path planning is significantly meaningful.
  • 164
  • 30 Nov 2023
Topic Review
20% Project
The 20% Project is an initiative where company employees are allocated twenty-percent of their paid work time to pursue personal projects. The objective of the program is to inspire innovation in participating employees and ultimately increase company potential. The 20% Project was influenced by a comparable program, launched in 1948, by manufacturing multinational 3M which required employees to have 15% time: to dedicate up to 15 percent of their paid hours to a personal interest. Technology company Google is credited for popularising the 20% concept, with many of their current services being products of employee pet projects. Some schools have also utilized the principles of the 20% Project to foster creativity and boost productivity.
  • 2.0K
  • 25 Nov 2022
Topic Review
2001 Massacre of Plaza de Mayo
The 2001 Massacre of Plaza de Mayo was a slaughter of people at Plaza de Mayo (May Square), Buenos Aires, Argentina, and around this area that took place on December 20, 2001. Five people were murdered. The names of the fatal victims were: Carlos Almiron, Gustavo Ariel Benedetto, Diego Lamagna, Alberto Marquez and Gaston Marcelo Riva. The perpetrators tried to kill four more people (Marcelo Dorado, Martin Galli, Sergio Ruben Sanchez, and Paula Simonetti), but they did not succeed. A total of 277 injuries was reported.These crimes were committed under Fernando de la Rua’s presidential term in which Argentina was suffering one of its deepest crises and people were rioting in different cities around the nation. These incidents left a total of 39 people that were murdered across the country, among them 7 children.The trial against the 17 defendants started on February 24, 2014.
  • 619
  • 17 Oct 2022
Topic Review
2004 Indian Ocean Tsunami in Malaysia
The tsunami is one of the deadliest natural disasters, responsible for more than 260,000 deaths and billions in economic losses over the last two decades. The footage of the devastating power of the 2004 Indian Ocean tsunami perhaps remains vivid in the memory of most survivors, and Malaysia was one of the countries affected by the unprecedented 2004 tsunami. It was the first time the Malaysian government had managed such a great disaster. A compilation of post-event observations regarding tsunami characteristics is first presented in the form of maps, followed by building damage, including damage modes of wall failure, total collapse, debris impact and tilting of structures.
  • 12.4K
  • 25 Aug 2022
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