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Topic Review
Tunneling Quantum Dynamics in Ammonia
Ammonia is a well-known example of a two-state system and must be described in quantum-mechanical terms. In this article, we will explain the tunneling phenomenon that occurs in ammonia molecules from the perspective of trajectory-based quantum dynamics, rather than the usual quantum probability perspective.
  • 791
  • 03 Aug 2021
Topic Review
Tunneling Nanotubes for Glioblastoma Treatment
Communication between cells helps tumors acquire resistance to chemotherapy and makes the struggle against cancer more challenging. Tunneling nanotubes (TNTs) are long channels able to connect both nearby and distant cells, contributing to a more malignant phenotype. This finding might be useful in designing novel strategies of drug delivery exploiting these systems of connection. This would be particularly important to reach tumor niches, where glioblastoma stem cells proliferate and provoke immune escape, thereby increasing metastatic potential and tumor recurrence a few months after surgical resection of the primary mass. Along with the direct inhibition of TNT formation, TNT analysis, and targeting strategies might be useful in providing innovative tools for the treatment of this tumor.
  • 689
  • 29 Mar 2022
Topic Review
Tunneling Nanotubes
Tunneling nanotubes (TNTs) are recognized long membrane nanotubes connecting distance cells. In the last decade, growing evidence has shown that these subcellular structures mediate the specific transfer of cellular materials, pathogens, and electrical signals between cells. As intercellular bridges, they play a unique role in embryonic development, collective cell migration, injured cell recovery, cancer treatment resistance, and pathogen propagation. Although TNTs have been considered as potential drug targets for treatment, there is still a long way to go to translate the research findings into clinical practice.
  • 648
  • 10 Mar 2021
Topic Review
Tunneling Nanotube in the Nervous System
Tunneling nanotubes (TNTs) are thin, hollow plasma membrane projections that directly connect the lumen of one cell to the lumen of another cell, thereby transferring different cargoes between the two connected cells. TNTs have been shown to play very prominent roles in neuronal development and serve as highways for neurodegenerative diseases in the brain. 
  • 437
  • 08 Oct 2023
Topic Review
Tunneling and Blocking Oxides on Memory Cells
Flash memory is an electronic, non-volatile information storage device that can be electrically erased and reprogrammed. Ideally, the information stored in such a device should be preserved for long when the power is switched off. There are two flash memories designs at present: floating gate and charge trapping. Both of them work by storage of electrical charges in the space above the channel of the MOSFET. The charge storage volume of the flash cell, either poly-Si floating gate or charge trapping dielectric/dielectric stack is confined between blocking and tunnel oxides for electrical insulation from the gate electrode and Si substrate. Blocking and tunnelling oxides are important parts of the flash memory cells, as they affect retention, endurance and program/erase speed performance.
  • 819
  • 20 Oct 2023
Topic Review
Tunnel Technology
Tunnel Technology is an infrastructure-based technology that facilitates crop production for an extended period. The technology protects the crop from climate change effects, prolongs production, and makes efficient use of resources.
  • 521
  • 19 Jul 2021
Topic Review
Tuning Catalytic Activity of Nanozymes
Nanozymes are alternatives to natural enzymes but remain slightly inferior in catalytic activity. Thus, it is necessary to focus on several important factors that affect the enzymatic activity of nanozymes as well as strategies to enhance activity, thereby laying a theoretical foundation for the design of nanozymes. One of the distinct features of enzymes are their ultrahigh reaction rate. Correspondingly, nanozymes with comparable or even superior activity are long-standing pursuits.
  • 397
  • 08 Mar 2023
Topic Review
Tuning between Nuclear Organization and Functionality in Health
The organization of eukaryotic genome in the nucleus, a double-membraned organelle separated from the cytoplasm, is highly complex and dynamic. The functional architecture of the nucleus is confined by the layers of internal and cytoplasmic elements, including chromatin organization, nuclear envelope associated proteome and transport, nuclear–cytoskeletal contacts, and the mechano-regulatory signaling cascades. The size and morphology of the nucleus could impose a significant impact on nuclear mechanics, chromatin organization, gene expression, cell functionality and disease development. The maintenance of nuclear organization during genetic or physical perturbation is crucial for the viability and lifespan of the cell. Abnormal nuclear envelope morphologies, such as invagination and blebbing, have functional implications in several human disorders, including cancer, accelerated aging, thyroid disorders, and different types of neuro-muscular diseases. 
  • 625
  • 07 Mar 2023
Topic Review
Tunicamycin in the Therapeutic Implication of Cancers
Tunicamycin (TM) is one of the potent nucleoside antibiotics and an inhibitor of aberrant glycosylation in various cancer cells, including breast cancer, gastric cancer, and pancreatic cancer, parallel with the inhibition of cancer cell growth and progression of tumors. Like chemotherapies such as doxorubicin (DOX), 5′fluorouracil, etoposide, and cisplatin, TM induces the unfolded protein response (UPR) by blocking aberrant glycosylation. Consequently, stress is induced in the endoplasmic reticulum (ER) that promotes apoptosis.
  • 134
  • 05 Mar 2024
Topic Review
Tunicamycin in Breast Cancer Research
Tunicamycin is a small biological molecule, that blocks a specific step of the protein N-glycosylation pathway in the endoplasmic reticulum (ER), i.e., the catalytic activity of N-acetylglusosaminyl 1-phosphate transferase (GPT).
  • 543
  • 15 Apr 2022
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