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Topic Review
Tuxedo
Tuxedo (Transactions for Unix, Extended for Distributed Operations) is a middleware platform used to manage distributed transaction processing in distributed computing environments. Tuxedo is a transaction processing system or transaction-oriented middleware, or enterprise application server for a variety of systems and programming languages. Developed by AT&T in the 1980s, it became a software product of Oracle Corporation in 2008 when they acquired BEA Systems. Tuxedo is now part of the Oracle Fusion Middleware.
  • 520
  • 27 Oct 2022
Topic Review
TUTOR (Programming Language)
TUTOR (also known as PLATO Author Language) is a programming language developed for use on the PLATO system at the University of Illinois at Urbana-Champaign around 1965. TUTOR was initially designed by Paul Tenczar for use in computer assisted instruction (CAI) and computer managed instruction (CMI) (in computer programs called "lessons") and has many features for that purpose. For example, TUTOR has powerful answer-parsing and answer-judging commands, graphics, and features to simplify handling student records and statistics by instructors. TUTOR's flexibility, in combination with PLATO's computational power (running on what was considered a supercomputer in 1972), also made it suitable for the creation of many non-educational lessons—that is, games—including flight simulators, war games, dungeon style multiplayer role-playing games, card games, word games, and medical lesson games such as Bugs and Drugs (BND).
  • 358
  • 03 Nov 2022
Topic Review
Tutor
A tutor, formally also called an academic tutor, is a person who provides assistance or tutelage to one or more people on certain subject areas or skills. The tutor spends a few hours on a daily, weekly, or monthly basis to transfer their expertise on the topic or skill to the student. Tutoring can take place in different settings,
  • 561
  • 23 Nov 2022
Topic Review
Tutedhara
A tutedhara (Nepali) or jahru (Newari) is a traditional drinking fountain found in Nepal. It is a water reservoir built out of stone with a tap that can be opened and closed. These structures are either free-standing or integrated into the wall of another building. They depend on a water well or a dhunge dhara to be filled. Only a few of them are in use today, but some of the stone parts have been put to other uses, and there are contemporary equivalents. The best known tutedhara is the one built into a wall in the royal palace on Kathmandu Durbar Square. It is inscribed with a poem dedicated to the goddess Kali, written in fifteen different languages.
  • 583
  • 02 Nov 2022
Topic Review
Tuta absoluta
The South American tomato pinworm Tuta absoluta (Meyrick) has aggressively invaded the African continent. Since its first detection in North Africa in Morocco and Tunisia in 2008, it has successfully invaded the entire southern, eastern and western Africa, where it has been on the offensive, causing significant damage to Solanaceous food crops. 
  • 3.4K
  • 31 May 2021
Topic Review
Tuskegee Syphilis Experiment
The Tuskegee Study of Untreated Syphilis in the African American Male was a clinical study conducted between 1932 and 1972 by the United States Public Health Service. The purpose of this study was to observe the natural history of untreated syphilis; the African-American men in the study were only told they were receiving free health care from the Federal government of the United States. The Public Health Service started the study in 1932 in collaboration with Tuskegee University (then the Tuskegee Institute), a historically black college in Alabama. Investigators enrolled in the study a total of 600 impoverished, African-American sharecroppers from Macon County, Alabama. Of these men, 399 had latent syphilis, with a control group of 201 men who were not infected. As an incentive for participation in the study, the men were promised free medical care, but were deceived by the PHS, who disguised placebos, ineffective methods, and diagnostic procedures as treatment. The men who had syphilis were never informed of their diagnosis, despite the risk of infecting others, and the fact that the disease could lead to blindness, deafness, mental illness, heart disease, bone deterioration, collapse of the central nervous system, and death.. According to the Centers for Disease Control and Prevention, the men were told that they were being treated for "bad blood,” a colloquialism that described various conditions such as syphilis, anemia and fatigue. "Bad blood"—specifically the collection of illnesses the term included—was a leading cause of death within the southern African-American community. The men were initially told that the study was only going to last six months, but it was extended to 40 years. After funding for treatment was lost, the study was continued without informing the men that they would never be treated. None of the infected men were treated with penicillin despite the fact that by 1947, the antibiotic had become the standard treatment for syphilis. Study clinicians could have chosen to treat all syphilitic subjects and close the study, or split off a control group for testing with penicillin. Instead, they continued the study without treating any participants; they withheld treatment and information about it from the subjects. In addition, scientists prevented participants from accessing syphilis treatment programs available to other residents in the area. The study continued, under numerous Public Health Service supervisors, until 1972, when a leak to the press resulted in its termination on November 16 of that year. The victims of the study, all African-American, included numerous men who died of syphilis, 40 wives who contracted the disease and 19 children born with congenital syphilis. The 40-year Tuskegee Study of Untreated Syphilis in the African American Male study was a major violation of ethical standards. Researchers knowingly failed to treat participants appropriately after penicillin was proven to be an effective treatment for syphilis and became widely available. Moreover, participants remained ignorant of the study clinicians’ true purpose, which was to observe the natural course of untreated syphilis. The revelation in 1972 of study failures by a whistleblower, Peter Buxtun, led to major changes in U.S. law and regulation concerning the protection of participants in clinical studies. Now studies require informed consent, communication of diagnosis and accurate reporting of test results. The Tuskegee Syphilis Study, cited as "arguably the most infamous biomedical research study in U.S. history," led to the 1979 Belmont Report and to the establishment of the Office for Human Research Protections (OHRP). It also led to federal laws and regulations requiring institutional review boards for the protection of human subjects in studies involving them. The OHRP manages this responsibility within the United States Department of Health and Human Services (HHS). On May 16, 1997, President Bill Clinton formally apologized on behalf of the United States to victims of the study.
  • 2.1K
  • 07 Nov 2022
Biography
Tushar Kanti Das Roy
Tushar K. Das Roy, researcher and technologist, science popularizer, entrepreneur, was born in Bangladesh, India. He graduated from the University of Calcutta, India, where he received his Engineering Degree, later moved to Berlin, Germany and there he obtained his Diplomm-Ingenierung at the University of Berlin, Germany; his title of Dr.-Ing. he got it from TU-Clausthal, Germany. He worked
  • 964
  • 02 Apr 2023
Topic Review
Turtles in Malaysia
Approximately 356 species of turtles inhabit saltwater and freshwater habitats globally, except in Antarctica. Twenty-four species of turtles have been reported in Malaysia, four of which are sea turtles. The state of Terengganu harbored the highest number of turtles, with 17 different reported species. 
  • 1.5K
  • 19 Sep 2022
Topic Review
Turning Indoles into Therapeutics via Targeted Delivery Technologies
Developing therapeutics for inflammatory diseases is challenging due to physiological mucosal barriers, systemic side effects, and the local microbiota. In the search for novel methods to overcome some of these problems, drug delivery systems that improve tissue-targeted drug delivery and modulate the microbiota are highly desirable. Microbial metabolites are known to regulate immune responses, an observation that has resulted in important conceptual advances in areas such as metabolite pharmacology and metabolite therapeutics. Indeed, the doctrine of “one molecule, one target, one disease” that has dominated the pharmaceutical industry in the 20th century is being replaced by developing therapeutics which simultaneously manipulate multiple targets through novel formulation approaches, including the multitarget-directed ligands. Thus, metabolites may not only represent biomarkers for disease development, but also, being causally linked to human diseases, an unexploited source of therapeutics.
  • 347
  • 07 Mar 2023
Topic Review
Turning and Sensing System for Pressure Ulcers Prevention
Pressure ulcers (PU) are one of the most frequent hazards of long-term bedridden patients. With the continuous increase of aging, the number of long-term bedridden disabled and semi-disabled elderly people is increasing. At the same time, there is a serious shortage of professional pressure ulcer nursing staff.
  • 357
  • 20 Dec 2021
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