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Topic Review
UCSC Genome Browser
The UCSC Genome Browser is an on-line, and downloadable, genome browser hosted by the University of California, Santa Cruz (UCSC). It is an interactive website offering access to genome sequence data from a variety of vertebrate and invertebrate species and major model organisms, integrated with a large collection of aligned annotations. The Browser is a graphical viewer optimized to support fast interactive performance and is an open-source, web-based tool suite built on top of a MySQL database for rapid visualization, examination, and querying of the data at many levels. The Genome Browser Database, browsing tools, downloadable data files, and documentation can all be found on the UCSC Genome Bioinformatics website.
  • 1.3K
  • 09 Oct 2022
Topic Review
UCLA-VA Multi-campus PM&R Residency Program
UCLA-VA Multi-campus PM&R Residency Program is an ACGME-accredited residency program in physical medicine and rehabilitation based in Los Angeles , California . With four clinical fellows in pain medicine and 26 PM&R residents enrolled in the program, it is one of the largest PM&R residency programs in the West Coast and one of a handful of PM&R programs in the U.S. to have its own pain medicine fellowship program.
  • 1.1K
  • 03 Nov 2022
Topic Review
UCHL1 Gene
Ubiquitin C-terminal hydrolase L1.
  • 388
  • 23 Dec 2020
Topic Review
UC Berkeley College of Natural Resources
The College of Natural Resources (CNR), a college of the University of California, Berkeley, is the oldest college in the UC system and home to several internationally top-ranked programs. CNR's Department of Agriculture & Economics is considered to be one of the most prestigious schools in agricultural economics in the world, ranking #1 according to the Journal of Agricultural and Applied Economics, #1 by the Chronicle of Higher Education, #1 by Perry for its Ph.D. programs and in International Trade, #1 by the National Research Council in Agricultural & Resource Economics, and #1 by U.S. News in Environmental/Environmental Health. In environmental disciplines, QS World Rankings recognizes the University of California, Berkeley, as the world's leading university in Environmental Studies with 100 points in Academic Reputation. U.S. News also ranks it as the best global university for environment and ecology. A study of AJAE authors and their university affiliations found it to have the highest number of pages per research faculty member. Established in 1868 as the College of Agriculture under the federal Morrill Land-Grant Acts, CNR is the first state-run Agricultural Experiment Station. The college is home to four academic departments: Agriculture and Resource Economics; Environmental Science, Policy, and Management; Nutritional Sciences and Toxicology; and Plant and Microbial Biology, and one interdisciplinary program, Energy and Resources Group. Faculty include 40 Fulbright Fellows, 30 American Association for the Advancement of Science Fellows, 19 National Academy of Sciences members, 12 Guggenheim Fellows, 9 American Academy of Arts and Sciences members, 7 MacArthur Fellows, 4 Nobel Laureates, 3 Wolf Prize winners, and 2 World Food Prize winners. The Dean of the College is Prof. David Ackerly.
  • 457
  • 01 Nov 2022
Topic Review
Ubuntu in Post-Apartheid South Africa
Ubuntu has been defined as a moral quality of human beings, as a philosophy or an ethic, as African humanism, and as a worldview. 
  • 689
  • 17 Feb 2024
Topic Review
UBR Box-Containing E3 Ligases
UBR box E3 ligases, also called N-recognins, are integral components of the N-degron pathway. Representative N-recognins include UBR1, UBR2, UBR4, and UBR5, and they bind destabilizing N-terminal residues, termed N-degrons. Understanding the molecular bases of their substrate recognition and the biological impact of the clearance of their substrates on cellular signaling pathways can provide valuable insights into the regulation of these pathways.
  • 636
  • 13 Aug 2021
Topic Review
Ubisol-Q10 for Neurodegenerative Disease Treatment
It is well established and accepted that excessive oxidative stress is a key contributor to neurodegenerative diseases, driving interest in the development and application of redox therapies including the use of coenzyme-Q10 (CoQ10). However, in several human clinical trials, CoQ10 has failed to show efficacy, possibly due to poor tissue penetration and inability to deliver it parenterally. Ubisol-Q10 is a nanomicellar, water-dispersible formulation of CoQ10 that was created by combining CoQ10 with an amphiphilic and self-emulsifying molecule of polyoxyethanyl α-tocopheryl sebacate (PTS). This stable formulation is suitable for parenteral delivery and when tested at micromolar concentrations (well within FDA guidelines), it showed unprecedented neuroprotection, both in cellular models and animal models of chronic progressive neurodegeneration of both Parkinson’s and Alzheimer’s type. Systemic application of Ubisol-Q10 in drinking water stopped further progression of ongoing neurodegeneration as long as Ubisol-Q10 was provided. Mechanistically, this treatment with Ubisol-Q10 mobilized astroglia response in the CNS, quenched reactive oxygen species, prevented cell senescence, activated autophagy, reduced inflammation, and stabilized mitochondria. Importantly, these biochemical outcomes are accompanied by a significant improvement in behavioral deficits typically observed in animals with Parkinson’s and Alzheimer’s disease. Thus, Ubisol-Q10 is a promising candidate for developing a disease-modifying therapeutic intervention for neurodegenerative diseases that can be easily administered as drinking tonic.
  • 680
  • 20 May 2021
Topic Review
Ubiquitylation-Mediated DNA Double-Strand Break Repair
The proper function of DNA repair is indispensable for eukaryotic cells since accumulation of DNA damages leads to genome instability and is a major cause of oncogenesis. Ubiquitylation and deubiquitylation play a pivotal role in the precise regulation of DNA repair pathways by coordinating the recruitment and removal of repair proteins at the damaged site. Here, we summarize the most important post-translational modifications (PTMs) involved in DNA double-strand break repair.
  • 1.2K
  • 13 Oct 2020
Topic Review
Ubiquitylation of ABA Receptors/PP2Cs
Post-translational modifications play a fundamental role in regulating protein function and stability. In particular, protein ubiquitylation is a multifaceted modification involved in numerous aspects of plant biology.  Regarding proteolytic functions of Ub, Lys-48-linked branched chains are the most common chain type for proteasomal degradation, whereas promotion of endocytosis and vacuolar degradation is triggered through monoubiquitylation or Lys63-linked chains introduced in integral or peripheral plasma membrane proteins. Hormone signaling relies on regulated protein turnover, and specifically the half-life of ABA signaling components is regulated both through the ubiquitin-26S proteasome system and the endocytic/vacuolar degradation pathway. 
  • 593
  • 22 Jul 2021
Topic Review
Ubiquitylation and ISGylation
Ubiquitylation and ISGylation are protein post-translational modifications (PTMs) and two of the main events involved in the activation of pattern recognition receptor (PRRs) signals allowing the host defense response to viruses.
  • 582
  • 21 Feb 2022
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