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Topic Review
Umtsimba
A traditional Swazi wedding ceremony is called umtsimba (Template:IPA-ss), where the bride commits herself to her new family for the rest of her life. The ceremony is a celebration that includes members of both the bride's - and the groom's - natal village. There are stages to the wedding that stretch over a few days. Each stage is significant, comprising symbolic gestures that have been passed on from generation to generation. The first stage is the preparation of the bridal party before leaving their village. The second stage is the actual journey of the bridal party from their village to the groom's village. The third stage is the first day of the wedding ceremony that spans three days, and starts on the day the bridal party arrives at the grooms’ village. Thereafter the actual wedding ceremony takes place which is the fourth stage of the umtsimba. The fifth stage takes place the day after the wedding ceremony and is known as kuteka, which is the actual wedding. The final stage may take place the day after the wedding day, and is when the bride gives the groom's family gifts and is the first evening the bride spends with the groom. Although the traditional wedding ceremony has evolved in modern times, the details below are based on historic accounts of anthropologist Hilda Kuper and sociological research describing the tradition
  • 571
  • 19 Oct 2022
Topic Review
Umbilical Endometriosis and Pathogenic Theory Proposal
Endometriosis is a benign gynecological disorder that affects about 5% of reproductive-aged women. The pelvic cavity is the most common location of endometriotic implants, but about 12% of lesions are extragenital and, among the extra-pelvic sites, endometriosis of the abdominal wall (AWE) is the most common. Umbilical endometriosis (UE), or Villar’s nodule, as first described by Villar in 1886, is defined as the presence of endometrial glands and/or stroma within the umbilicus.
  • 352
  • 28 Feb 2022
Topic Review
Umbilical Cord-Derived Wharton’s Jelly in Orthopedic Regenerative Medicine
Wharton’s jelly (WJ) is an allogenic tissue comprised of connective tissue located within the umbilical cord. Wharton’s jelly resists torsional and compressive stresses during fetal development levied upon the umbilical vessels. The primitive mesenchymal stem cells reside within the UC-derived WJ [15]. These perinatal MSCs resemble embryonic stem cells (ESCs) but exhibit many properties of adult MSCs. Wharton’s jelly-derived mesenchymal stem cells (WJSCs) exhibit lower expression levels of pluripotent markers compared to ESCs, indicating multipotency rather than pluripotency [16,17]. Wharton’s jelly contains the highest concentration of MSCs/mL compared to other tissue types.
  • 677
  • 08 Nov 2021
Topic Review
Umbilical Cord-Derived Mesenchymal Stromal Cells in COVID-19 Treatment
Coronavirus disease 2019 (COVID-19), the pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which counts more than 650 million cases and more than 6.6 million of deaths worldwide, affects the respiratory system with typical symptoms such as fever, cough, sore throat, acute respiratory distress syndrome (ARDS), and fatigue. Uumbilical-cord-derived mesenchymal stromal cells (UC-MSCs)  could be a potent tool against phlogistic status, not only during the last pandemic caused by SARS-CoV-2, but also for other future pandemic or respiratory tract inflammatory diseases. However, a series of challenges still lies ahead, comprising the accomplishment of all the tests required by the regulatory bodies.
  • 302
  • 30 Jun 2023
Topic Review
Umbilical Cord Blood-Derived sEV
Small extracellular vesicles (sEV) are a group of particles of nanometric size, released by virtually all cells. These vesicles function as biologic messengers, carrying proteins, lipids and nucleic acids as a form of paracrine cellular communication. Umbilical cord blood (UCB) is a priviledged source of sEV, due to its abundance in naïve cells with strong regenerative and immunomodulatory potential. Hence, UCB-derived sEV can be exploited for their therapeutic properties, taking advantage of nature's tools for achieving homeostasis.
  • 620
  • 29 Sep 2021
Topic Review
Umbilical Cord Blood Stem-Cell Transplantations
One of the biggest concern in blood transplantations is the graft-versus-host disease (GVHD) because its chronicity is a leading cause of morbidity and mortality. In this regard, umblical cord blood transplantations (UCBT) is a preferable source of donor hematopoietic stem cells (HSCs) compared to bone marrow transplantation (BMT). In this report, the authors provide strategies to expand umbilical stem cells and enhance efficacy of transplantation into indicated patients with chronic diseases (e.g. cancers, non malignant hemoglobinopathies).
  • 460
  • 18 Dec 2020
Biography
Uma Narayan
Uma Narayan (born 16 April 1958) is an Indian feminist scholar, and a Professor of Philosophy at Vassar College. She is the author of Dislocating Cultures: Identities, Traditions and Third World Feminism in which Narayan disputes feminism as a solely Western notion and intrusion, while challenging assumptions that India n feminism is based on Western models. In particular, a notion of homogen
  • 1.4K
  • 30 Dec 2022
Topic Review
UM-EVs involved in tumor progression
Extracellular vesicles (EVs) carry molecules derived from donor cells and are able to alter the properties of recipient cells. They are important players during the genesis and progression of tumors. Uveal melanoma (UM) is the most common primary intraocular tumor in adults and is associated with a high rate of metastasis, primarily to the liver. However, the mechanisms underlying this process are poorly understood. In the present study, we analyzed the oncogenic potential of UM-derived EVs and their protein signature. We isolated and characterized EVs from five UM cell lines and from normal choroidal melanocytes (NCMs). BRCA1-deficient fibroblasts (Fibro-BKO) were exposed to the EVs and analyzed for their growth in vitro and their reprograming potential in vivo following inoculation into NOD-SCID mice. Mass spectrometry of proteins from UM-EVs and NCM-EVs was performed to determine a protein signature that could elucidate potential key players in UM progression. In-depth analyses showed the presence of exosomal markers, and proteins involved in cell-cell and focal adhesion, endocytosis, and PI3K-Akt signaling pathway. Notably, we observed high expression levels of HSP90, HSP70 and integrin V in UM-EVs. Our data bring new evidence on the involvement of UM-EVs in cancer progression and metastasis.
  • 555
  • 04 Apr 2021
Topic Review
Ulvan As a Seaweed-Derived Sulfated Polysaccharide
Cancer is one of the most worldwide spread diseases and causes maximum death. Treatment of cancer depends on the host immune system and the type of drugs. The inefficiency of conventional cancer treatments as a result of drug resistance, nontargeted delivery, and chemotherapy-related negative side effects has caused bioactive phytochemicals to come into focus. Ulvan is a polysaccharide derived from various green seaweeds of the Ulva species in the family Ulvaceae. It has been demonstrated to have potent anticancer and anti-inflammatory properties through the modulation of antioxidants. It is vital to understand the mechanisms underlying the biotherapeutic activities of Ulvan in cancer and its role in immunomodulation.
  • 514
  • 02 Jun 2023
Topic Review
Ulva (Enteromorpha) Polysaccharides and Oligosaccharides
The high-valued utilization of Ulva (previously known as Enteromorpha) bioresources has drawn increasing attention due to the periodic blooms of world-wide green tide. The polysaccharide is the main functional component of Ulva and exhibits various physiological activities. The Ulva oligosaccharide as the degradation product of polysaccharide not only possesses some obvious activities, but also possesses excellent solubility and bioavailability. Both Ulva polysaccharides and oligosaccharides hold promising potential in the food industry as new functional foods or food additives. Studies on Ulva polysaccharides and oligosaccharides are increasing and have been the focus of the marine bioresources field.
  • 2.5K
  • 19 Mar 2022
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