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Topic Review
Zen (Microarchitecture)
Zen is the codename for a computer processor microarchitecture from AMD, and was first used with their Ryzen series of CPUs in February 2017. The first Zen-based preview system was demonstrated at E3 2016, and first substantially detailed at an event hosted a block away from the Intel Developer Forum 2016. The first Zen-based CPUs codenamed "Summit Ridge" reached the market in early March 2017, Zen-derived Epyc server processors launched in June 2017 and Zen-based APUs arrived in November 2017. Zen is a clean sheet design that differs from the long-standing Bulldozer architecture. Zen-based processors use a 14 nm FinFET process, are reportedly more energy efficient, and can execute significantly more instructions per cycle. SMT has been introduced, allowing each core to run two threads. The cache system has also been redesigned, making the L1 cache write-back. Zen processors use three different sockets: desktop and mobile Ryzen chips use the AM4 socket, bringing DDR4 support; the high-end desktop Zen-based Threadripper chips support quad-channel DDR4 RAM and offer 64 PCIe 3.0 lanes (vs 24 lanes), using the TR4 socket; and Epyc server processors offer 128 PCI 3.0 lanes and octal-channel DDR4 using the SP3 socket. But not all Socket AM4 CPUs are based on Zen microarchitecture (the 7th gen APUs and Athlon X4s are based on Excavator microarchitecture). Zen is based on a SoC design. The memory, PCIe, SATA, and USB controllers are incorporated into the same chip as the processor cores. This has advantages in bandwidth and power, at the expense of chip complexity and die area. This SoC design allows the Zen microarchitecture to scale from laptops and small-form factor mini PCs to high-end desktops and servers.
  • 1.7K
  • 11 Nov 2022
Topic Review
Zellweger Spectrum Disorder
Zellweger spectrum disorder is a group of conditions that have overlapping signs and symptoms and affect many parts of the body.
  • 482
  • 24 Dec 2020
Topic Review
Zellige
Zellige (Arabic: [zˈliʑ]; Arabic: الزليج; also zelige or zellij) is mosaic tilework made from individually chiseled geometric tiles set into a plaster base. This form of Islamic art is one of the main characteristics of Moroccan architecture. It consists of geometrically patterned mosaics, used to ornament walls, ceilings, fountains, floors, pools and tables.
  • 1.1K
  • 06 Oct 2022
Topic Review
Zeiss Inner Rail
Zeiss Inner Rail, often simply called Zeiss rail, is a ringless telescopic sight mounting system introduced by Zeiss in 1990 as an alternative to traditional ring mounts. A patent was granted in 1992, and the patent expired in 2008. The mounting system is now also offered on sights sold by other major manufacturers, such as Blaser, Leica, Minox, Meopta, Nikon, Noblex (formerly Docter), Schmidt & Bender and Steiner. It has therefore, in some sense, become the industry standard for scope mounting rails. The system has so far seen most use on the European high end market.
  • 594
  • 30 Nov 2022
Topic Review
ZED Depth Sensors
The ZED depth sensor is considered as one of the world's fastest depth camera. It is composed of stereo cameras  with dual 4 mega-pixel RGB sensors. 
  • 3.4K
  • 09 Mar 2022
Topic Review
Zebrafish: Neurological Diseases
Most neurodegenerative diseases are currently incurable, with large social and economic impacts. Recently, there has been renewed interest in investigating natural products in the modern drug discovery paradigm as novel, bioactive small molecules. Moreover, the discovery of potential therapies for neurological disorders is challenging and involves developing optimized animal models for drug screening. In contemporary biomedicine, the growing need to develop experimental models to obtain a detailed understanding of malady conditions and to portray pioneering treatments has resulted in the application of zebrafish to close the gap between in vitro and in vivo assays. Zebrafish in pharmacogenetics and neuropharmacology are rapidly becoming a widely used organism. Brain function, dysfunction, genetic, and pharmacological modulation considerations are enhanced by both larval and adult zebrafish. Bioassay-guided identification of natural products using zebrafish presents as an attractive strategy for generating new lead compounds. Here, we see evidence that the zebrafish's central nervous system is suitable for modeling human neurological disease and we review and evaluate natural product research using zebrafish as a vertebrate model platform to systematically identify bioactive natural products. Finally, we review recently developed zebrafish models of neurological disorders that have the potential to be applied in this field of research.
  • 1.1K
  • 29 Oct 2020
Topic Review
Zebrafish Research
Zebrafish (Danio rerio) are a versatile and invaluable model organism in scientific research. These small, freshwater fish have gained prominence due to their transparency, rapid development, and genetic tractability. Zebrafish embryos are transparent, allowing researchers to observe developmental processes in real time, making them ideal for studies in developmental biology. Their genetic makeup can be easily manipulated, enabling forward and reverse genetics studies, including the use of advanced techniques like CRISPR-Cas9. Zebrafish have made significant contributions to various research areas, such as neurobiology, where their neural development and behaviors are studied. They are also crucial in disease modeling, including cancer, cardiovascular diseases, and neurodegenerative disorders, providing insights into disease mechanisms and potential therapies. Furthermore, zebrafish play a pivotal role in drug discovery, toxicology, regenerative medicine, and environmental studies. Despite certain limitations, their unique attributes continue to drive breakthroughs in scientific understanding and medical advancements.
  • 312
  • 09 Oct 2023
Topic Review
Zebrafish Nephron Segment Development
Nephrons are the functional units which comprise the kidney. Each nephron contains a number of physiologically unique populations of specialized epithelial cells that are organized into discrete domains known as segments.
  • 421
  • 24 Mar 2023
Topic Review
Zebrafish Motile Cilia
Zebrafish is a vertebrate teleost widely used in many areas of research. As embryos, they develop quickly and provide unique opportunities for research studies owing to their transparency for at least 48 h post fertilization. Zebrafish have many ciliated organs that include primary cilia as well as motile cilia. Using zebrafish as an animal model helps to better understand human diseases such as Primary Ciliary Dyskinesia (PCD), an autosomal recessive disorder that affects cilia motility, currently associated with more than 50 genes. 
  • 766
  • 22 Sep 2021
Topic Review
Zebrafish Models of Neuroblastoma
For nearly a decade, researchers in the field of pediatric oncology have been using zebrafish as a model for understanding the contributions of genetic alternations to the pathogenesis of neuroblastoma (NB), and exploring the molecular and cellular mechanisms that underlie neuroblastoma initiation and metastasis.
  • 912
  • 18 Mar 2021
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