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Topic Review
VEGF/VEGFR Axis for Cancer Therapy
The vascular endothelial growth factor (VEGF)/vascular endothelial growth factor receptor (VEGFR) axis is indispensable in the process of angiogenesis and has been implicated as a key driver of tumor vascularization. Consequently, several strategies that target VEGF and its cognate receptors, VEGFR-1 and VEGFR-2, have been designed to treat cancer. While therapies targeting full-length VEGF have resulted in an improvement in both overall survival and progression-free survival in various cancers, these benefits have been modest. In addition, the inhibition of VEGFRs is associated with undesirable off-target effects. Moreover, VEGF splice variants that modulate sprouting and non-sprouting angiogenesis have been identified. Cues within the tumor microenvironment determine the expression patterns of these variants. Noteworthy is that the mechanisms of action of these variants challenge the established norm of VEGF signaling.
  • 345
  • 15 Dec 2022
Topic Review
VEGF Alters Photoreceptor Function
Vascular endothelial growth factor (VEGF) is a major therapeutic target for blood–retina barrier (BRB) breakdown in diabetic retinopathy (DR), age-related macular degeneration (AMD), and other hypoxic retinal vascular disorders. VEGF is a direct functional regulator of photoreceptors and VEGF up-regulation in DR is a contributing factor to diabetes-induced alteration of photoreceptor function. This information is critical to the understanding of the therapeutic effect and to the care of anti-VEGF drug-treated patients for BRB breakdown in DR, AMD, and other hypoxic retinal vascular disorders. 
  • 777
  • 22 Sep 2021
Topic Review
VEGF
VEGF-A (also called VEGF) is a member of the mammalian platelet-derived growth factor (PDGF) supergene family which also includes VEGF-B, VEGF-C, VEGF-D and placental growth factor (PlGF).
  • 799
  • 05 May 2021
Topic Review
Vegetative Desiccation Tolerance in Pteridophytes
Pteridophytes (lycophytes and ferns) is a highly diverse group of plant species that occupy a wide range of habitats including ecosystems with extreme climatic conditions. There is a significant number of pteridophytes that can tolerate desiccation by temporarily arresting their metabolism in the dry state and reactivating it upon rehydration. In agreement with their phylogenetic position, vegetative desiccation tolerance in pteridophytes has previously been proposed as an intermediate mechanism between the constitutive mechanisms exhibited by bryophytes and the inducible response of desiccation-tolerant angiosperms. Protection mechanisms in pteridophytes include accumulation of sugars (mainly sucrose), increase in the levels of enzymatic (for example, SOD, CAT, POD, GR) and non-enzymatic antioxidants, induction of proteins with a protective role (like LEA, ELIPs), among others.
  • 889
  • 12 May 2022
Topic Review
Vegetation Optical Depth
The vegetation optical depth (VOD) parameterizes the extinction (attenuation & scattering) effects due to the vegetation affecting the microwave radiations propagating through the vegetation canopy. It is retrieved from both passive and active microwave remotely sensed observations. It is related almost linearly to the vegetation water content and indirectly to vegetation water status and biomass. It has been retrieved from several satellites operating at different frequencies and provides a long-term record of the vegetation dynamics over land surfaces since 1978. VOD is complementary to classically used vegetation indices derived from multi-spectral images but it is less affected by sun illumination and atmospheric effects than optical vegetation indices.
  • 6.4K
  • 27 Nov 2020
Topic Review
Vegetation Dynamics and Climate Change
Climate extremes and their impacts on vegetation dynamics have been of great concern to the ecosystem and environmental conservation and the policy-decision makers. Of great concern now is that climate change impacts on vegetation dynamics have influenced the global terrestrial ecosystem adversely, thus making ecosystems vulnerability one of the current issues in ecological studies. For instance, the negative consequences attributed to natural hazards associated with climate extremes have been estimated to be billions of dollars across the globe. Accordingly, vegetation dynamics are influenced by several factors including climate change, environmental and climatic components among others. These can expend considerable impact on the water balance by evapotranspiration, interception and development strategy which has the potential to lead to vegetation degradation in a wide variety of ecosystems and biodiversity.
  • 1.3K
  • 30 Sep 2021
Topic Review
Vegetarian Diets and Chronic Kidney Disease Complications
A growing body of evidence has demonstrated that higher consumption of plant-based foods and the nutrients found in vegetarian and plant-based diets are associated with numerous health benefits, including improved blood pressure, glycemic control, lipid levels, body mass index, and acid–base parameters. Furthermore, there has been increasing recognition that vegetarian and plant-based diets may have potential salutary benefits in preventing the development and progression of chronic kidney disease (CKD). While increasing evidence shows that vegetarian and plant-based diets have nephroprotective effects, there remains some degree of uncertainty about their nutritional adequacy and safety in CKD (with respect to protein-energy wasting, hyperkalemia, etc.). 
  • 539
  • 06 Feb 2024
Topic Review
Vegetal-Derived Bioactive Compounds in Colorectal Cancer
Colorectal cancer is one of the leading causes of morbidity and mortality today. Knowledge of its pathogenesis has made it possible to advance the development of different therapeutic strategies. However, the appearance of drug resistance constitutes one of the main causes of treatment failure. Bioactive compounds of vegetable origin are being studied as a new strategy to improve antitumor treatment, due to their ability to regulate the pathways involved in the development of carcinogenesis or processes that are decisive in its evolution, including multidrug resistance. In vitro and in vivo studies of these substances in combination with cytotoxic drugs have shown that they reduce resistance and increase therapeutic efficacy. 
  • 243
  • 02 Nov 2023
Topic Review
Vegetables on the Modulation of Platelet Function
Cardiovascular diseases (CVDs) are a primary cause of deaths worldwide. Thrombotic diseases, specifically stroke and coronary heart diseases, account for around 85% of CVDs-induced deaths. Platelets (small circulating blood cells) are responsible for the prevention of excessive bleeding upon vascular injury, through blood clotting (haemostasis). However, their unnecessary activation results in thrombotic diseases. Hence, it is critical to control platelet activation under pathological conditions. Regular diet has a strong relationship with the development of CVDs, and therefore reviewing their beneficial effects on the modulation of platelet function is essential.  Here,  a few important, regularly used vegetables and demonstrate their effects on the modulation of platelet activation are listed.  
  • 488
  • 29 Mar 2022
Topic Review
Vegetables Irrigated with Untreated Wastewater
Vegetables are commonly cultivated with untreated wastewater and consumed by human beings who often ignore their harmful impacts on health. The industrialization and urbanization in developing countries have led to the release of increasing amounts of heavy metals (HM) into the environment. Regular monitoring of metal concentration levels in contaminated soils and edible plants is essential to prevent their excessive build-up in the diet and food chains.
  • 2.2K
  • 25 Dec 2020
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