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Topic Review
Zinc-Based Metal-Organic Frameworks
The design and structural frameworks for targeted drug delivery of medicinal compounds and improved cell imaging have been developed with several advantages. However, metal-organic frameworks (MOFs) are supplemented tremendously for medical uses with efficient efficacy. These MOFs are considered as an absolutely new class of porous materials, extensively used in drug delivery systems, cell imaging, and detecting the analytes, especially for cancer biomarkers, due to their excellent biocompatibility, easy functionalization, high storage capacity, and excellent biodegradability. While Zn-metal centers in MOFs have been found by enhanced efficient detection and improved drug delivery, these Zn-based MOFs have appeared to be safe as elucidated by different cytotoxicity assays for targeted drug delivery. On the other hand, the MOF-based heterogeneous catalyst is durable and can regenerate multiple times without losing activity. Therefore, as functional carriers for drug delivery, cell imaging, and chemosensory, MOFs’ chemical composition and flexible porous structure allowed engineering to improve their medical formulation and functionality.
  • 1.5K
  • 16 Feb 2022
Topic Review
Zinc-Alpha2-Glycoprotein (AZGP1) and Fibrotic Kidney Disease
Chronic Kidney Disease (CKD) is a condition characterized by a gradual loss of kidney function over time. It is typically accompanied by progressive fibrosis of the tubulointerstitial compartment.
  • 464
  • 26 Jan 2022
Topic Review
Zinc Transporters of the Brain
Zinc ions play an essential role in the physiology of brain function. Zinc acts as a potent neuromodulatory agent and signaling ions, regulating healthy brain development and the function of both neurons and glial cells. Therefore, the concentration of zinc within the brain and its cells is tightly controlled. Zinc transporters are key regulators of (extra-)cellular zinc levels, and deregulation of zinc homeostasis and zinc transporters has been associated with neurodegenerative and neuropsychiatric disorders. Here, more information is provided about the presence of specific zinc transporters and their subcellular localization within brain cells (neurons, astrocytes).
  • 578
  • 12 May 2021
Topic Review
Zinc Transporters in Different Biological Kingdoms
Zinc transporters take up/release zinc ions (Zn2+) across biological membranes and maintain intracellular and intra-organellar Zn2+ homeostasis. Since this process requires a series of conformational changes in the transporters, detailed information about the structures of different reaction intermediates is required for a comprehensive understanding of their Zn2+ transport mechanisms. Various Zn2+ transport systems have been identified in bacteria, yeasts, plants, and humans. 
  • 154
  • 12 Mar 2024
Topic Review
Zinc Transport
Zinc is a micronutrient involved in many fundamental roles that are vital for routine bodily functions. A tight control of its concentration, however, is necessary to ensure balance inside the cells. Zinc transporters are thus essential to maintain cellular homeostasis.
  • 738
  • 25 Mar 2021
Topic Review
Zinc Supplementation on Nutritional Status in CKD
Zinc is one of the most important and essential trace elements required by all living organisms for many physiologic functions, with three major biological roles catalytic, structural and regulatory ones. It is the second most abundant metal in mammalian tissues, after iron, with almost 90% of that found in muscle and bone. Likewise, the cellular Zn2+ concentrations are nearly as high as those of major metabolites like the ATP. Zinc is an essential cofactor that influences the expression and activity of numerous enzymes, transcription factors and regulatory proteins.
  • 559
  • 19 Jan 2023
Topic Review
Zinc Supplementation in Pediatric Gastrointestinal Diseases
Children with inflammatory bowel disease (IBD), celiac disease, and those receiving long-term proton pump inhibitor treatments are particularly susceptible to zinc deficiency (ZD). ZD in children with celiac disease and IBD is attributed to insufficient intake, reduced absorption, and increased intestinal loss as a result of the inflammatory process. Zinc plays a crucial role in maintaining the integrity of the gastric mucosa and exerts a gastroprotective action against gastric lesions. 
  • 359
  • 26 Sep 2023
Topic Review
Zinc Signaling in Prostate Cancer
Prostate cancer (PCa) is one of the most common cancers and the second leading cause of cancer-related death among men worldwide. Despite progresses in early diagnosis and therapeutic strategies, prognosis for patients with advanced PCa remains poor. Therefore, it is necessary to develop novel strategies to prevent, diagnose and effectively treat PCa patients in clinic. Noteworthily, a unique feature of healthy prostate is its highest level of zinc content among all soft tissues in the human body, which dramatically decreases during prostate tumorigenesis. Here, we discuss clinical applications of zinc-containing compounds and proteins involved in PCa signaling pathways. Based on currently available studies, we conclude that zinc can serve as a biomarker in PCa diagnosis and therapies.
  • 935
  • 05 Nov 2021
Topic Review
Zinc Oxide Nanoparticles Seed Priming against Environmental Stresses
Drastic climate changes over the years have triggered environmental challenges for wild plants and crops due to fluctuating weather patterns worldwide. This has caused different types of stressors, responsible for a decrease in plant life and biological productivity, with consequent food shortages, especially in areas under threat of desertification. Nanotechnology-based approaches have great potential in mitigating environmental stressors, thus fostering a sustainable agriculture. Zinc oxide nanoparticles (ZnO NPs) have demonstrated to be biostimulants as well as remedies to both environmental and biotic stresses. Their administration in the early sowing stages, i.e., seed priming, proved to be effective in improving germination rate, seedling and plant growth and in ameliorating the indicators of plants’ well-being. Seed nano-priming acts through several mechanisms such as enhanced nutrients uptake, improved antioxidant properties, ROS accumulation and lipid peroxidation. The target for seed priming by ZnO NPs is mostly crops of large consumption or staple food, in order to meet the increased needs of a growing population and the net drop of global crop frequency, due to climate changes and soil contaminations. 
  • 364
  • 11 Jan 2024
Topic Review
Zinc Oxide Nanoparticles in Enhancing Plant Stress Resistance
Zinc oxide nanoparticles (ZnO nanoparticles) have gained substantial attention from researchers worldwide for their capacity to alleviate the detrimental impacts of both biotic and abiotic stress on plants, concurrently reducing dependence on environmentally harmful chemicals.
  • 294
  • 19 Jan 2024
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