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Topic Review
Nanoparticle Constructions to Target Staphylococcus aureus Pathogenesis
The clinical infections by Staphylococcus aureus caused an increase in morbidity and mortality rates and treatment costs, aggravated by the emergence of drug-resistant strains. Different nanotechnology-enabled approaches are being investigated that can improve the paradigm of therapeutics against S. aureus pathogenesis and infections. Nanomaterials provide a suitable platform to address this challenge, with the potential to control biofilm formation, intracellular parasitism and multidrug resistance where conventional therapies show limited efficacy. Herein, the large diversity of nanoparticles and their applications to combat S. aureus pathogenesis, including in combination with antibiotics and phytochemicals, is presented and their specific biological actions are highlighted.
  • 413
  • 22 May 2024
Topic Review
Air Travel
The first aircraft at the beginning of the 20th century had too weak engines to carry passengers. Air travel that time mainly took place in large airships. The first commercial flight took place on January 1st, 1914, across Tampa Bay, Florida, with one paying passenger. The first regular passenger air transport took place in Germany, between Berlin and Weimar, from 1919. The 1920s brought fast growth of passenger aviation. In 1932, the first serial production of aircraft for passenger air travel started. However, at that time, transatlantic passenger flights were still only performed by airships. Jet aircraft replaced propeller aircraft in the 1950s. Now there are eight million commercial flights every year (status: June 2011). The crew of an airplane consists of the captain, the first, second and third officer, the flight attendants, the flight engineer, the loadmaster, the pilot and the purser. About eight million people fly every day, yielding 3.1 billion passengers in air travel in 2013. Besides people and their luggage, cargo is transported, about 140,000 tons every day, which is equivalent to 50 million tons per year. There are nearly 60 million jobs in air travel; the global turnover of the airline industry is more than 700 billion USD, with about 2.6% net profit. International aviation reached a new record in 2010 with more than 30.5 million commercial flights. 35% of the total departures in 2010 took place in North America, 25% in Asia, 24% in Europe, 10% in Latin America and the Caribbean, 3% in Oceania and 3% in Africa. Fastest growth is in Asia Pacific, Latin America, the Caribbean, Africa and the Middle East. Until 2030, an increase of the number of commercial flights to 52 million is estimated.
  • 1.8K
  • 22 May 2024
Topic Review
MANDIR: More than just a religious temple
Mandir, a religious temple for Hindus to worship. This is the glimpse everybody thinks as they hear the word "Mandir" and a great mistake they make is that they don't think anything beyond this thought. In ancient times, Mandirs were not just a place of worship but also................
  • 128
  • 21 May 2024
Topic Review
Łukaszyk-Karmowski Metric
The Łukaszyk–Karmowski metric (LK-metric) defines a distance between two random variables or vectors. LK-metric is not a metric as it does not satisfy the identity of indiscernibles axiom of the metric; for the same random variables, its value is greater than zero, providing they are not both degenerated.
  • 123
  • 20 May 2024
Topic Review
Helicobacter pylori infection, pathogenicity, and therapeutic advances
A primer on Helicobacter pylori virulence factors, pathogenicity, gastric conditions that are caused by infection, and treatment modalities. This entry is adapted from the peer-reviewed paper 10.3390/pathogens13050392
  • 468
  • 17 May 2024
Topic Review
Find the perfect pair for every occasion
Chino pants are a versatile wardrobe staple known for their timeless style, comfort, and versatility. With their classic design and wide range of options available, choosing the right pair of chinos can be overwhelming
  • 318
  • 16 May 2024
Topic Review
Sustainable and innovative processing for safe (healthy) foods
Sustainable and innovative technologies involving high-pressure processing (HPP), high-pressure homogenization (HPH), high-pressure carbon dioxide (HPCD), pulsed electric fields (PEF), ultrasounds (US), and microwaves (MV), among others, as well as traditional methods of food treatment like heating, fermentation, and drying or smoking are increasingly applied in food preservation and the modification of selected physicochemical or sensory properties. The aim of this Special Issue is to highlight new challenges in the treatment of food for obtaining traditional or new but safe products, including functional foods, with high or modified nutritional (bioaccessibility and bioavailability) and sensory values.
  • 378
  • 15 May 2024
Topic Review Peer Reviewed
Supporting Doctoral Candidates through Completion and Final Examination
Completion and final examination comprise the final stages of a doctoral program and represent the culmination of the doctoral candidates’ years of research. In this entry, completion is defined as the writing and submission of a doctoral thesis, and final examination is defined as the viva voce. Over the years, the format and scope of doctoral degrees has expanded and a variety of formats are now offered. In addition to the traditional research-only doctoral degree, professional, practice-based, and new route programs also contain a taught element alongside research. However, the creation of a substantive thesis or practice-based alternative addressing a novel research question is common to all. In contrast, processes and formats of viva voces vary across the globe. These range from private, closed-door defenses to assessed or ritualistic public defense presentations. For both completion and final examination, there are many practical and psychological hurdles that need to be navigated in order for the candidate to attain their doctoral degree. This entry will highlight these aspects as well as provide evidence-based guidance for supervisors in supporting their doctoral candidates through these daunting final stages.
  • 601
  • 15 May 2024
Topic Review Peer Reviewed
Cushion Gas Consideration for Underground Hydrogen Storage
Due to the increasing world population and environmental considerations, there has been a tremendous interest in alternative energy sources. Hydrogen plays a major role as an energy carrier due to its environmentally benign nature. The combustion of hydrogen releases water vapor while it also has a vast industrial application in aerospace, pharmaceutical, and metallurgical industries. Although promising, hydrogen faces storage challenges. Underground hydrogen storage (UHS) presents a promising method of safely storing hydrogen. The selection of the appropriate cushion gas for UHS is a critical aspect of ensuring the safety, efficiency, and reliability of the storage system. Cushion gas plays a pivotal role in maintaining the necessary pressure within the storage reservoir, thereby enabling consistent injection and withdrawal rates of hydrogen. One of the key functions of the cushion gas is to act as a buffer, ensuring that the storage pressure remains within the desired range despite fluctuations in hydrogen demand or supply. This is achieved by alternately expanding and compressing the cushion gas during the injection and withdrawal cycles, thereby effectively regulating the overall pressure dynamics within the storage facility. Furthermore, the choice of cushion gas can have significant implications on the performance and long-term stability of the UHS system. Factors such as compatibility with hydrogen, cost-effectiveness, availability, and environmental impact must be carefully considered when selecting the most suitable cushion gas. The present study provides a comprehensive review of different types of cushion gases commonly used in UHS, including nitrogen, methane, and carbon dioxide. By examining the advantages, limitations, and practical considerations associated with each option, the study aims to offer valuable insights into optimizing the performance and reliability of UHS systems. Ultimately, the successful implementation of UHS hinges not only on technological innovation but also on strategic decisions regarding cushion gas selection and management. By addressing these challenges proactively, stakeholders can unlock the full potential of hydrogen as a clean and sustainable energy carrier, thereby contributing to the global transition towards a low-carbon future.
  • 671
  • 15 May 2024
Topic Review Peer Reviewed
Displacement Micropump with Check Valves for Diabetes Care—The Challenge of Pumping Insulin at Negative Pressure
The displacement micropump with passive check valves is an attractive solution for precise insulin infusion in patients with type I diabetes. Unlike most insulin pumps that push insulin from a cartridge using a piston, a displacement micropump will first pull insulin from the reservoir before infusing it into the patient. This dual sequence introduces new challenges in terms of insulin stability, notably if the reservoir is not pressurized. After an introduction to displacement micropumps and a brief review of the insulin degradation mechanism, micropump design rules are discussed in light of microfluidic theory.
  • 655
  • 14 May 2024
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