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Topic Review
Research Progress of the Wheat × Maize System
Chromosome elimination resulting in haploids is achieved by rapid loss of chromosomes from one parent during the zygote stage and is an important procedure to produce doubled haploid (DH) lines in plants. During crosses between an emasculated wheat (Triticum aestivum L.) and maize (Zea mays L.) as pollen donors, the complete loss of maize chromosomes results in wheat haploid embryos. Through embryo rescue and chromosome doubling processes, pure lines with stable traits can be quickly obtained. The technique is called the “Wheat × Maize System”.
  • 355
  • 05 Mar 2024
Topic Review
Theranostic Uses of the Heme Pathway in Neuro-Oncology
ALA PDT, first approved as a topical therapy to treat precancerous skin lesions in 1999, targets the heme pathway selectively in cancers. When provided with excess ALA, the fluorescent photosensitizer PpIX accumulates primarily in cancer tissue, and ALA PDD is used to identify bladder and brain cancers as a visual aid for surgical resection. ALA PDT has shown promising anecdotal clinical results in recurrent glioblastoma multiforme. ALA SDT represents a noninvasive way to activate ALA PDT and has the potential to achieve clinical success in the treatment of both intracranial and extracranial cancers. 
  • 117
  • 05 Mar 2024
Topic Review
γδ T Cells in Staphylococcus aureus Infections
The growth of antibiotic-resistant bacterial infections necessitates focusing on host-derived immunotherapies. γδ T cells are an unconventional T cell subset, making up a relatively small portion of healthy circulating lymphocytes but a substantially increased proportion in mucosal and epithelial tissues. γδ T cells are activated and expanded in response to bacterial infection, having the capability to produce proinflammatory cytokines to recruit neutrophils and clear infection. They also play a significant role in dampening immune response to control inflammation and protecting the host against secondary challenge, making them promising targets when developing immunotherapy. Importantly, γδ T cells have differential metabolic states influencing their cytokine profile and subsequent inflammatory capacity.
  • 324
  • 05 Mar 2024
Topic Review
Vestibular Assessment and Rehabilitation in the Operational Environment
The vestibular system, comprised of the semicircular canals, otolith organs, and eighth cranial nerves in the peripheral system, and the brainstem, brain, and cerebellum in the central system, is essential for gaze and postural stability. It allows service members to keep their eyes fixed on a target while their head is moving, and additionally contributes to the maintenance of balance. Evaluation of the vestibular system requires a systematic assessment of the visual, vestibular, and balance systems; technology can aid in this assessment. While technology can assist physical and occupational therapists in performing vestibular assessment and rehabilitation, not all such technologies are conducive to delivery of healthcare in an operational environment. In this context, the environment is characterized by the presence of extreme conditions and constrained resource availability.
  • 128
  • 05 Mar 2024
Topic Review
Thermographic Techniques for Skin Cancer Diagnosis
Infrared (IR) thermography is one of the most promising technologies now available for the early detection of malignant diseases (such as skin and breast cancers). Its significant strengths are the absence of contact and dangerous radiation; it is also a non-invasive and cost-effective technique.
  • 159
  • 05 Mar 2024
Topic Review
Myocardial Work in Coronary Artery Disease
Myocardial ischemia caused by coronary artery disease (CAD) and the presence of metabolic abnormalities and microvascular impairments detected in patients with diabetes mellitus (DM) are a common cause of left ventricular (LV) dysfunction. Transthoracic echocardiography is the most-used, non-invasive imaging method for the assessment of myocardial contractility. The accurate evaluation of LV function is crucial for identifying patients who are at high risk or may have worse outcomes. Myocardial work (MW) is emerging as an alternative tool for the evaluation of LV systolic function, providing additional information on cardiac performance when compared to conventional parameters such as left ventricular ejection fraction (LVEF) and global longitudinal strain (GLS) because it incorporates deformation and load into its analysis. The potential of MW in various conditions is promising and it has gained increased attention. 
  • 93
  • 05 Mar 2024
Topic Review
Metabolomic Signatures of Treatment Response in Bladder Cancer
Bladder cancer (BC) stands as one of the most prevalent urological malignancies, with over 500 thousand newly diagnosed cases annually. Treatment decisions in BC depend on factors like the risk of recurrence, the type of tumor, and the stage of the disease. While standard therapeutic approaches encompass transurethral resection of the bladder tumor, radical cystectomy, and chemo- or immunotherapy, these methods exhibit limited efficacy in mitigating the aggressive and recurrent nature of bladder tumors. To overcome this challenge, it is crucial to develop innovative methods for monitoring and predicting treatment responses among patients with BC. Metabolomics is gaining recognition as a promising approach for discovering biomarkers. It has the potential to reveal metabolic disruptions that precisely reflect how BC patients respond to particular treatments, providing a revolutionary method to improve accuracy in monitoring and predicting outcomes.
  • 218
  • 05 Mar 2024
Topic Review
Histoplasmosis in Solid Organ Transplantation
Histoplasma capsulatum, the etiological agent for histoplasmosis, is a dimorphic fungus that grows as a mold in the environment and as a yeast in human tissues. It has a broad global distribution with shifting epidemiology. While in immunocompetent individuals infection is usually self-resolving, solid organ transplant recipients are at increased risk of symptomatic disease with dissemination to extrapulmonary tissue. Diagnosis of histoplasmosis relies on direct observation of the pathogen (histopathology, cytopathology, and culture) or detection of antigens, antibodies, or nucleic acids. All transplant recipients with histoplasmosis warrant therapy, though the agent of choice and duration of therapy depends on the severity of disease.
  • 113
  • 05 Mar 2024
Topic Review
Dynamical Systems Research in Psychotherapy
In psychotherapy research, the first applications of dynamical systems research (DSR) date back to the 1990s. Over time, DSR has developed three main lines of research: the study of oscillations in synchronization; the study of oscillations between stability and flexibility of process variables (S–F oscillations); the mathematical modeling to analyze the evolution of psychotherapy process.
  • 186
  • 05 Mar 2024
Topic Review
Lateral Lumbar Interbody Fusion
Lumbar interbody fusion procedures have seen a significant evolution over the years, with various approaches being developed to address spinal pathologies and instability, including posterior lumbar interbody fusion (PLIF), transforaminal lumbar interbody fusion (TLIF), anterior lumbar interbody fusion (ALIF), and lateral lumbar interbody fusion (LLIF). LLIF, a pivotal technique in the field, initially emerged as extreme/direct lateral interbody fusion (XLIF/DLIF) before the development of oblique lumbar interbody fusion (OLIF). To ensure comprehensive circumferential stability, LLIF procedures are often combined with posterior stabilization (PS) using pedicle screws. 
  • 114
  • 05 Mar 2024
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