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Topic Review
Slope Stability Analysis
Slope stability analysis is performed to assess the safe design of a human-made or natural slopes (e.g. embankments, road cuts, open-pit mining, excavations, landfills etc.) and the equilibrium conditions. Slope stability is the resistance of inclined surface to failure by sliding or collapsing. The main objectives of slope stability analysis are finding endangered areas, investigation of potential failure mechanisms, determination of the slope sensitivity to different triggering mechanisms, designing of optimal slopes with regard to safety, reliability and economics, designing possible remedial measures, e.g. barriers and stabilization. Successful design of the slope requires geological information and site characteristics, e.g. properties of soil/rock mass, slope geometry, groundwater conditions, alternation of materials by faulting, joint or discontinuity systems, movements and tension in joints, earthquake activity etc. The presence of water has a detrimental effect on slope stability. Water pressure acting in the pore spaces, fractures or other discontinuities in the materials that make up the pit slope will reduce the strength of those materials. Choice of correct analysis technique depends on both site conditions and the potential mode of failure, with careful consideration being given to the varying strengths, weaknesses and limitations inherent in each methodology. Before the computer age stability analysis was performed graphically or by using a hand-held calculator. Today engineers have a lot of possibilities to use analysis software, ranges from simple limit equilibrium techniques through to computational limit analysis approaches (e.g. Finite element limit analysis, Discontinuity layout optimization) to complex and sophisticated numerical solutions (finite-/distinct-element codes). The engineer must fully understand limitations of each technique. For example, limit equilibrium is most commonly used and simple solution method, but it can become inadequate if the slope fails by complex mechanisms (e.g. internal deformation and brittle fracture, progressive creep, liquefaction of weaker soil layers, etc.). In these cases more sophisticated numerical modelling techniques should be utilised. Also, even for very simple slopes, the results obtained with typical limit equilibrium methods currently in use (Bishop, Spencer, etc.) may differ considerably. In addition, the use of the risk assessment concept is increasing today. Risk assessment is concerned with both the consequence of slope failure and the probability of failure (both require an understanding of the failure mechanism). Within the last decade (2003) Slope Stability Radar has been developed to remotely scan a rock slope to monitor the spatial deformation of the face. Small movements of a rough wall can be detected with sub-millimeter accuracy by using interferometry techniques.
  • 5.9K
  • 19 Oct 2022
Topic Review
Plant-Dominant Low-Protein Diet
Plant-dominant low-protein diet (LPD), also abbreviated as "PLADO" is a patient-centered LPD of 0.6–0.8 g/kg/day composed of >50% plant-based sources, administered by dietitians trained in providing nutrition care to patients with non-dialysis-dependent chronic kidney disease (CKD). PLADO's composition and meal plans can be designed and adjusted based on individualized needs and according to the principles of precision nutrition. The goal of PLADO is to slow kidney disease progression, to avoid or delay dialysis therapy initiation, and to ensure cardiovascular health and longevity.  The ideal type of PLADO is a heart-healthy, safe, flexible, and feasible diet that could be the centerpiece of the conservative and preservative management of CKD.
  • 5.9K
  • 05 Nov 2020
Topic Review
Chemical Bonding of H2O
Water (H2O) is a simple triatomic bent molecule with C2v molecular symmetry and bond angle of 104.5° between the central oxygen atom and the hydrogen atoms. Despite being one of the simplest triatomic molecules, its chemical bonding scheme is nonetheless complex as many of its bonding properties such as bond angle, ionization energy, and electronic state energy cannot be explained by one unified bonding model. Instead, several traditional and advanced bonding models such as simple Lewis and VESPR structure, valence bond theory, molecular orbital theory, isovalent hybridization, and Bent's rule are discussed below to provide a comprehensive bonding model for H2O, explaining and rationalizing the various electronic and physical properties and features manifested by its peculiar bonding arrangements.
  • 5.9K
  • 18 Oct 2022
Topic Review
Holobiont
A holobiont is an assemblage of a host and the many other species living in or around it, which together form a discrete ecological unit, though there is controversy over this discreteness. The components of a holobiont are individual species or bionts, while the combined genome of all bionts is the hologenome. The concept of the holobiont was initially defined by Dr. Lynn Margulis in her 1991 book Symbiosis as a Source of Evolutionary Innovation, though the concept has subsequently evolved since the original definition. Holobionts include the host, virome, microbiome, and other members, all of which contribute in some way to the function of the whole. Well-studied holobionts include reef-building corals and humans.
  • 5.9K
  • 14 Oct 2022
Topic Review
Snake Dry Bites
Snake ‘dry bites’ are characterized by the absence of venom being injected into the victim during a snakebite incident. The dry bite mechanism and diagnosis are quite complex, and the lack of envenoming symptoms in these cases may be misinterpreted as a miraculous treatment or as proof that the bite from the perpetrating snake species is rather harmless.
  • 5.9K
  • 01 Dec 2020
Topic Review
Causes of Transsexuality
The study of the causes of transsexuality investigates gender identity formation of transgender people, especially those who are transsexual. Transgender people have a gender identity that does not match their assigned sex, often resulting in gender dysphoria. The causes of transsexuality have been studied for decades. The most studied factors are biological, especially brain structure differences in relation to biology and sexual orientation. Environmental factors have also been proposed. Transgender brain studies, especially those on trans women who are sexually attracted to women (gynephilic), and those on trans men who are sexually attracted to men (androphilic), are limited, as they include a small number of tested individuals. The available research indicates that the brain structure of androphilic trans women with early-onset gender dysphoria is closer to the brain structure of cisgender women's and less like cisgender men's. It also reports that both androphilic trans women and trans women with late-onset gender dysphoria who are gynephilic have different brain phenotypes, and that gynephilic trans women differ from both cisgender female and male controls in non-dimorphic brain areas. Cortical thickness, which is generally thicker in cisgender women's brains than in cisgender men's brains, may also be thicker in trans women's brains, but is present in a different location to cisgender women's brains. For trans men, research indicates that those with early-onset gender dysphoria and who are gynephilic have brains that generally correspond to their assigned sex, but that they have their own phenotype with respect to cortical thickness, subcortical structures, and white matter microstructure, especially in the right hemisphere. Hormone use can also affect transgender people's brain structure; it can cause transgender women's brains to become closer to those of cisgender women, and morphological increments observed in the brains of trans men might be due to the anabolic effects of testosterone. Twin studies suggest that there are likely genetic causes of transsexuality, although the precise genes involved are not fully understood. One study published in the International Journal of Transgender Health found that 20% of identical twin pairs in which at least one twin was trans were both trans, compared to only 2.6% of non-identical twins who were raised in the same family at the same time, but were not genetically identical. Ray Blanchard created a taxonomy of male-to-female transsexualism that proposes two distinct etiologies for androphilic and gynephilic individuals that has become controversial, supported by J. Michael Bailey, Anne Lawrence, James Cantor and others, but opposed by Charles Allen Moser, Julia Serano, and the World Professional Association for Transgender Health.
  • 5.9K
  • 20 Oct 2022
Topic Review
SSC Aero
The SSC Ultimate Aero is a mid-engined sports car that was produced by SSC North America (formerly known as Shelby SuperCars) from 2004 until 2013. The SSC Ultimate Aero held the world production car speed record title, according to the Guinness World Records, from 2007 (when it was officially timed at 410 km/h) until the introduction of the Bugatti Veyron Super Sport in 2010. In April 2013, the Guinness World Records temporarily disqualified the Veyron's record time for a period of five days due to concerns about electronic speed limiting changing the function of the car, but after investigation reinstated the Veyron as the record holder. The SSC Ultimate Aero was not sold with electronic driver aids such as an anti-lock braking system or traction control system, as according to Jerod Shelby (no relations to Carroll Shelby), "Early design philosophy on the car was to make it a driver's car. I wanted a car that you not only throttled with your right foot but at times you could steer with your right foot and a sensor."
  • 5.9K
  • 04 Nov 2022
Topic Review
Zwitterionic Dental Biomaterials
Biofilms are formed on surfaces inside the oral cavity covered by the acquired pellicle and develop into a complex, dynamic, microbial environment. Oral biofilm is a causative factor of dental and periodontal diseases. Accordingly, novel materials that can resist biofilm formation have attracted significant attention. Zwitterionic polymers (ZPs) have unique features that resist protein adhesion and prevent biofilm formation while maintaining biocompatibility. Recent literature has reflected a rapid increase in the application of ZPs as coatings and additives with promising outcomes. 
  • 5.9K
  • 29 Dec 2020
Topic Review
Children's Television Series
Children's television series are television programs designed for children, normally scheduled for broadcast during the morning and afternoon when children are awake. They can sometimes run during the early evening, allowing younger children to watch them after school. The purpose of these shows is mainly to entertain or educate.
  • 5.9K
  • 28 Nov 2022
Topic Review
Types of Transcatheter Aortic Valve Replacement Devices
Transcatheter aortic valve replacement (TAVR) was originally conceptualized in the early 1990s, largely inspired by the pioneering experiences in the field of percutaneous transluminal coronary angioplasty.
  • 5.9K
  • 03 Aug 2022
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