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Topic Review
Extracorporeal Blood Purification Techniques for Septic Hyperinflammation
Various techniques for extracorporeal blood purification can decrease levels of elevated proinflammatory cytokines in septic shock, potentially mitigating the severity of the systemic inflammatory response. Some methods are effective in removing endotoxins, especially in sepsis caused by Gram-negative bacteria, which may aid in stabilizing the patient’s condition. Blood purification can enhance hemodynamic stability and reduce the need for vasopressors, crucial for managing septic shock. Techniques like continuous renal replacement therapy (CRRT) offer simultaneous management of acute kidney injury—a frequent complication in septic shock—alongside the removal of toxins and cytokines.
  • 82
  • 13 Mar 2024
Topic Review
Diversity and Distribution of Sturgeon Parasites
Sturgeon species have inhabited the world’s seas and rivers for more than 200 million years and hold significant taxonomic significance, representing a strong conservation interest in aquatic biodiversity as well as in the economic sector, as their meat and eggs (caviar) are highly valuable goods. Currently, sturgeon products and byproducts can be legally obtained from aquaculture as a sustainable source. Intensive farming practices are accompanied by parasitic infestations, while several groups of parasites have a significant impact on both wild and farmed sturgeons.
  • 167
  • 13 Mar 2024
Topic Review
HTLV-1 Tax Structure Models
Human T-cell Leukemia Virus type 1 (HTLV-1) is a human retrovirus responsible for leukaemia in 5 to 10% of infected individuals. Among the viral proteins, Tax has been described as directly involved in virus-induced leukemogenesis. Tax is therefore an interesting therapeutic target. However, its 3D structure is still unknown and this hampers the development of drug-design-based therapeutic strategies. Several algorithms are available that can be used to predict the structure of proteins, particularly with the recent appearance of artificial intelligence (AI)-driven pipelines. However, Tax seems to be resistant to such predictions.
  • 148
  • 13 Mar 2024
Topic Review
Gene Therapy in Duchenne Muscular Dystrophy
Gene therapy allows for the modulation and correction of specific problem genes which are mutated in severe pathologies. The term “gene therapy” is loosely defined by many sources. The FDA defines it as “products whose effects are transferred through transcription/translation of genetic material via administration as nucleic acids, viruses, or genetically engineered microorganisms”. Duchenne muscular dystrophy (DMD) is a severe X-linked recessive muscle-wasting disease that results from mutations in the DMD gene on chromosome 21. Due to its poor survivorship, many interventions are being researched to improve outcomes for patients with this disease; gene therapy is an emerging field in this regard.
  • 226
  • 13 Mar 2024
Topic Review
Lignocellulolytic Microorganisms in Cereal Crop Residue Decomposition
The global escalation in cereal production, essential to meet growing population demands, simultaneously augments the generation of cereal crop residues, estimated annually at approximately 3107 × 106 Mg/year. Among different crop residue management approaches, returning them to the soil can be essential for various ecological benefits, including nutrient recycling and soil carbon sequestration. However, the recalcitrant characteristics of cereal crop residues pose significant challenges in their management, particularly in the decomposition rate. Microorganisms employ a range of mechanisms, such as the utilization of different enzymes that work in combination, to initiate oxidative attacks on plant litter. Consequently, this serves to reduce the recalcitrance of the lignocellulosic material, hence facilitating subsequent action by depolymerizing enzymes. Both fungi and bacteria have received increased attention for their ability to secrete a diverse range of lignocellulolytic enzymes.
  • 342
  • 13 Mar 2024
Topic Review
Causes of Asphalt Pavement Blistering
No theoretical model effectively explains the blistering process, which provokes functional distress in asphalt pavements worldwide. Over the years, it has been possible to observe blistering on many asphalt pavements, collect information related to the specific contexts of its occurrence, and formulate hypotheses on the potential causes.
  • 173
  • 13 Mar 2024
Topic Review
Muscle Tension Dysphonia
Muscle Tension Dysphonia (MTD) is a relatively new clinical entity that, despite being one of the most frequent causes of functional dysphonia, is little-known by many otorhinolaryngologists. MTD has been defined as a functional voice disorder characterized by excessive tension in the extrinsic laryngeal musculature during phonation but without organic or neurological alterations.
  • 161
  • 13 Mar 2024
Topic Review
Biological Role of FAM111A and FAM111B
Proteases are critical enzymes in cellular processes that regulate intricate events like cellular proliferation, differentiation, and apoptosis. FAM111A is implicated in DNA replication and replication fork protection, thereby maintaining genome integrity. Additionally, FAM111A functions as an antiviral factor against DNA and RNA viruses. FAM111B, a paralog of FAM111A, participates in cell cycle regulation and apoptosis. It influences the apoptotic pathway by upregulating anti-apoptotic proteins and modulating cell cycle-related proteins. Furthermore, FAM111B’s association with nucleoporins suggests its involvement in nucleo-cytoplasmic trafficking and plays a role in maintaining normal telomere length. FAM111A and FAM111B also exhibit some interconnectedness and functional similarity despite their distinct roles in cellular processes and associated diseases resulting from their dysfunction. 
  • 127
  • 13 Mar 2024
Topic Review
A Lightweight Remote Sensing Aircraft Object Detection Network
Remote sensing aircraft object detection is crucial in various applications. In civil aviation and the aerospace industry, it helps identify other aircraft, drones, or obstacles around an aircraft to prevent collisions and enhance aviation safety. It also aids in the real-time monitoring and tracking of civil aviation flights, cargo planes, and private aircrafts to ensure their flight path and status.
  • 195
  • 13 Mar 2024
Topic Review
Management Plan according to EOSS-P
hildhood obesity, affecting 29% of 7–9-year-olds across 33 European countries, is a significant public health challenge. Its persistence into adulthood poses grave health risks influenced by genetic, environmental, and socio-economic factors. Belgium introduced a new care pathway in December 2023, based on the Edmonton Obesity Staging System for Pediatrics (EOSS-P), addressing four health domains and staging obesity severity. This pathway operates across three levels: primary care physicians, Paediatric Multidisciplinary Obesity Management Centres (PMOCs), and Centers of Expertise for Paediatric Obesity Management (CEPOs). Each stage of EOSS-P demands tailored interventions. Early stages involve dietary interventions, physical activity promotion, and behavior modifications. As obesity severity progresses, treatments intensify, encompassing psychological support, anti-obesity medications, and, in some cases, bariatric surgery.
  • 90
  • 13 Mar 2024
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