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Topic Review
Giant Armadillo Optimization
A new bio-inspired metaheuristic algorithm called Giant Armadillo Optimization (GAO) is introduced, which imitates the natural behavior of giant armadillo in the wild. The fundamental inspiration in the design of GAO is derived from the hunting strategy of giant armadillos in moving towards prey positions and digging termite mounds.
  • 197
  • 18 Mar 2024
Topic Review
Micro-Grid Communication Protocols and Standards
A microgrid is a comprehensive system that includes energy storage, different energy sources, and loads within a certain boundary. It functions seamlessly, whether it is linked to, or works independently from, the main electrical grid, ensuring a consistent power supply. Microgrids consist of distributed energy resources (DER) and loads, which may be located in one place or spread throughout an electrical distribution network.
  • 476
  • 18 Mar 2024
Topic Review
Peripheral Arterial Atherosclerotic Disease in Elderly Patients
Atherosclerosis is a generalized and progressive disease. Ageing is a key risk factor for atherosclerosis progression that is associated with the increased incidence of ischemic events in supplied organs, including stroke, coronary events, limb ischemia, or renal failure. Cardiovascular disease is the leading cause of death and major disability in adults ≥ 75 years of age. Atherosclerotic occlusive disease affects everyday activity and quality of life, and it is associated with reduced life expectancy. Although there is evidence on coronary artery disease management in the elderly, there is insufficient data on the management in older patients presented with atherosclerotic lesions outside the coronary territory. Despite this, trials and observational studies systematically exclude older patients, particularly those with severe comorbidities, physical or cognitive dysfunctions, frailty, or residence in a nursing home. This results in serious critical gaps in knowledge and a lack of guidance on the appropriate medical treatment and referral for endovascular or surgical interventions. 
  • 113
  • 18 Mar 2024
Topic Review
Applications of Droplet Microsystems in Optics and Photonics
The micro- and nano-machining techniques applied to solid materials have yielded remarkable success in the semiconductor industry by integrating complex functionalities into microscale devices, thus spearheading the modern electronics revolution. Extending similar miniaturization strategies to process and assemble soft matter for creating multileveled functional structures over various length scales presents significant scientific and practical potential. Soft matter, including liquid crystals (LC), colloids, polymers, and biological substances, exhibits widespread influence across nature, living organisms, daily life, and industry. The biomimetic properties, responsiveness to stimuli, and efficacy in controlled release and sensing make soft matter extensively applicable in biology and chemistry.
  • 617
  • 18 Mar 2024
Topic Review
SARS-CoV-2 and Other Respiratory Viruses in Olfactory Pathophysiology
Acute respiratory viruses (ARVs) are the leading cause of diseases in humans worldwide. High-risk individuals, including children and the elderly, could potentially develop severe illnesses that could result in hospitalization or death in the worst case. The most common ARVs are the Human respiratory syncytial virus, Human Metapneumovirus, Human Parainfluenza Virus, rhinovirus, coronaviruses (including SARS and MERS CoV), adenoviruses, Human Bocavirus, enterovirus (-D68 and 71), and influenza viruses. The olfactory deficits due to ARV infection are a common symptom among patients. 
  • 117
  • 18 Mar 2024
Topic Review
Serious Games in Higher Education in Education 4.0
The digital transformation associated with the Fourth Industrial Revolution is having an impact on the way we teach. Under the term Education 4.0, new teaching methods, new technologies, as well as a student-centered approach, are expected to be used in teaching. One established method of teaching is the use of Serious Games, as it has various positive effects in terms of motivation and engagement. 
  • 212
  • 18 Mar 2024
Topic Review
Retrieval-Augmented Generation with Large Language Models in Nephrology
The integration of large language models (LLMs) into healthcare, particularly in nephrology, represents a significant advancement in applying advanced technology to patient care, medical research, and education. These advanced models have progressed from simple text processors to tools capable of deep language understanding, offering innovative ways to handle health-related data, thus improving medical practice efficiency and effectiveness. A significant challenge in medical applications of LLMs is their imperfect accuracy and/or tendency to produce hallucinations—outputs that are factually incorrect or irrelevant. This issue is particularly critical in healthcare, where precision is essential, as inaccuracies can undermine the reliability of these models in crucial decision-making processes. To overcome these challenges, various strategies have been developed. One such strategy is prompt engineering, like the chain-of-thought approach, which directs LLMs towards more accurate responses by breaking down the problem into intermediate steps or reasoning sequences. Another one is the retrieval-augmented generation (RAG) strategy, which helps address hallucinations by integrating external data, enhancing output accuracy and relevance. Hence, RAG is favored for tasks requiring up-to-date, comprehensive information, such as in clinical decision making or educational applications. 
  • 218
  • 18 Mar 2024
Topic Review
Machine Learning, Mechatronics, and Stretch Forming
The complexity of machine learning, mechatronics, and stretching forming is well known. Combining them was, is, and will be a necessity as they are closely interconnected disciplines within the field of manufacturing. It is a fact that in any industry, high productivity is achieved with the use of automated manufacturing processes. Intensive work was conducted throughout the year, and extraordinary techniques, equipment, and processes were upgraded or developed. Nevertheless, there are still issues that require optimal solutions.
  • 226
  • 18 Mar 2024
Topic Review
Assisted Robots in Therapies for Children
Children with autism spectrum disorder (ASD) have deficits that affect their social relationships, communication, and flexibility in reasoning. There are different types of treatment (pharmacological, educational, psychological, and rehabilitative). Currently, one way to address this problem is by using robotic systems to address the abilities that are altered in these children.
  • 169
  • 18 Mar 2024
Topic Review
Treatment Strategies for Anti-VEGF Resistance in neovascular AMD
Despite extensive use of intravitreal anti-vascular endothelial growth factor (anti-VEGF) biologics for over a decade, neovascular age-related macular degeneration (nAMD) or choroidal neovascularization (CNV) continues to be a major cause of irreversible vision loss in developed countries. Many nAMD patients demonstrate persistent disease activity or experience declining responses over time despite anti-VEGF treatment. The underlying mechanisms of anti-VEGF resistance are poorly understood, and no effective treatment strategies are available to date. Emerging strong evidence from animal models and clinical studies supports the roles of neovascular remodeling and arteriolar CNV formation in anti-VEGF resistance. Cholesterol dysregulation, inflammation, and ensuing macrophage activation are critically involved in arteriolar CNV formation and anti-VEGF resistance. Combination therapy by neutralizing VEGF and enhancing cholesterol removal from macrophages is a promising strategy to combat anti-VEGF resistance in CNV.
  • 107
  • 18 Mar 2024
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