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Topic Review
Glycogen Storage Diseases
Glycogen storage diseases (GSDs) are metabolic disorders of glycogen metabolism. In aggregate, GSDs are not considered rare diseases, but every individual type are. The overall estimated GSD incidence is 1 case per 20,000-43,000 live births, and a prevalence of 1:100,000 is considered for main types (including I, II, II, V and IX). There are 19 types which are classified by enzyme deficiency and affected tissue. Most of them are inherited in an autosomal recessive manner, except for one X-linked GSDIX and Danon subtypes. Disorders related with creation, deposits and degradation of glycogen, may primarily affect the liver (hepatic GSDs), the muscles (muscle GSDs), or in a multiorganic manner (mainly Pompe). The common characteristic of all types of GSDs is the alteration of some step in glycogenolysis/glycolysis pathway, as can be seen in figures 1a and 1b.
  • 2.5K
  • 13 May 2021
Topic Review
Pseudomonas aeruginosa
Pseudomonas aeruginosa is the most frequent cause of infection among non-fermenting Gram-negative bacteria, predominantly affecting immunocompromised patients, but its pathogenic role should not be disregarded in immunocompetent patients. seudomonas aeruginosa is the most frequent cause of infection among non-fermenting Gram-negative bacteria, predominantly affecting immunocompromised patients, but its pathogenic role should not be disregarded in immunocompetent patients.
  • 2.5K
  • 21 Jan 2021
Topic Review
Drone Brood
Drone brood homogenate (known as apilarnil or less apistimul) is a bee product obtained by the collection of drone (male honeybees)  larvae from drone cells of honey comb, from 3 to 11 days after hatching. Apilarnil, which may be defined as the male equivalent of royal jelly, is obtained from drone brood and then freeze-dried. Etymologically, the term originates from “api” for bee, “lar” for larvae, and “nil” as a shortened form of its discoverer’s name - Romanian apitherapist Nicholae Iliesiu. 
  • 2.5K
  • 17 Dec 2020
Topic Review
Sabot
A sabot (UK: /sæˈboʊ, ˈsæboʊ/, US: /ˈseɪboʊ/) is a structural device used in firearm or cannon ammunition to keep a sub-caliber flight projectile, such as a relatively small bullet or arrow-type projectile, in the center of the barrel when fired, if the bullet has a significantly smaller diameter than the bore diameter of the weapon used. The sabot component in projectile design is more than simply the relatively thin, tough and deformable seal known as a driving band or obturation ring needed to trap propellant gases behind a projectile, and also keep the projectile centered in the barrel, when the outer shell of the projectile is only slightly smaller in diameter than the caliber of the barrel. Driving bands and obturators are used to seal these full-bore projectiles in the barrel because of manufacturing tolerances; there always exists some gap between the projectile outer diameter and the barrel inner diameter, usually a few thousandths of an inch; enough of a gap for high pressure gasses to slip by during firing. Driving bands and obturator rings are made from material that will deform and seal the barrel as the projectile is forced from the chamber into the barrel. Small caliber jacketed bullets do not normally employ driving bands or obturators because the jacket material, for example copper or gilding metal, is deformable enough to serve that function, and the bullet is made slightly larger than the barrel for that purpose, (see full metal jacket bullet and driving band). Sabots certainly use driving bands and obturators, because the same manufacturing tolerance issues exist when sealing the saboted projectile in the barrel, but the sabot itself is a more substantial structural component of the in-bore projectile configuration (Drysdale 1978). Refer to the two APFSDS (armor-piercing fin-stabilized discarding sabot) pictures on the right to see the substantial material nature of a sabot to fill the bore diameter around the sub-caliber arrow-type flight projectile, compared to the very small gap sealed by a driving band or obturator to mitigate what is known classically as windage. More detailed cutaways of the internal structural complexity of advanced APFSDS saboted long rod penetrator projectiles can be found at reference 2.
  • 2.5K
  • 27 Oct 2022
Topic Review
Canine Adenoviruses
Canine adenoviruses (CAdVs) can be the backbones of viral vectors that could be applied in recombinant vaccines or for gene transfer in dogs and in serologically naïve humans. Although conventional plasmid-based reverse genetics systems can be used to construct CAdV vectors, their large genome size creates technical difficulties in gene cloning and manipulation. Here, we established an improved reverse genetics system for CAdVs using bacterial artificial chromosomes (BACs), in which genetic modifications can be efficiently and simply made through BAC recombineering. Our established BAC-based reverse genetics system for CAdVs would be a useful and powerful tool for basic and advanced practical studies with these viruses.
  • 2.5K
  • 04 Nov 2021
Topic Review
Purple Non-Sulfur Bacteria
Photosynthetic bacteria (PSB) are procaryotes capable of carrying out photosynthesis by converting light energy into chemical energy. These photosynthetic bacteria can either grow in the presence or absence of oxygen (aerobic and anaerobic conditions) and can either use organic or inorganic substances as an electron donor to fix the atmospheric nitrogen (N2) and carbon dioxide (CO2). The purple non-sulfur bacteria belong to the anoxygenic group of PSB, and their major groups include Rhodopseudomonas spp. and Rhodobacter spp. They are naturally present in wastewater ponds, lagoons, lakes, sediments, wetland ecosystems, moist soils, hypersaline systems, and marine ecosystems. They possess versatile metabolic pathways and, therefore, are widely used in the livestock and fisheries industries , in bioremedial methods for heavy metals and sewage, and in biofuel production (electricity or photohydrogen). Studies have also shown that purple non-sulfur bacteria (PNSB) help boost soil fertility when applied directly to the soil, whereas PNSB applied to plants help improve crop growth and yield.
  • 2.5K
  • 14 Oct 2022
Topic Review
Allosaurus
Allosaurus (/ˌæləˈsɔːrəs/) is a genus of large carnosaurian theropod dinosaur that lived 155 to 145 million years ago during the Late Jurassic epoch (Kimmeridgian to late Tithonian). The name "Allosaurus" means "different lizard" alluding to its unique (at the time of its discovery) concave vertebrae. It is derived from the Greek ἄλλος (allos) ("different, other") and σαῦρος (sauros) ("lizard / generic reptile"). The first fossil remains that could definitively be ascribed to this genus were described in 1877 by paleontologist Othniel Charles Marsh. As one of the first well-known theropod dinosaurs, it has long attracted attention outside of paleontological circles. Allosaurus was a large bipedal predator. Its skull was light, robust and equipped with dozens of sharp, serrated teeth. It averaged 8.5 meters (28 ft) in length for A. fragilis, with the largest specimens estimated as being 9.7 metres (32 ft) long. Relative to the large and powerful hindlimbs, its three-fingered forelimbs were small, and the body was balanced by a long and heavily muscled tail. It is classified as an allosaurid, a type of carnosaurian theropod dinosaur. The genus has a complicated taxonomy, and includes at least three valid species, the best known of which is A. fragilis. The bulk of Allosaurus remains have come from North America's Morrison Formation, with material also known from Portugal. It was known for over half of the 20th century as Antrodemus, but a study of the abundant remains from the Cleveland-Lloyd Dinosaur Quarry brought the name "Allosaurus" back to prominence and established it as one of the best-known dinosaurs. As the most abundant large predator in the Morrison Formation, Allosaurus was at the top of the food chain, probably preying on contemporaneous large herbivorous dinosaurs, and perhaps other predators. Potential prey included ornithopods, stegosaurids, and sauropods. Some paleontologists interpret Allosaurus as having had cooperative social behavior, and hunting in packs, while others believe individuals may have been aggressive toward each other, and that congregations of this genus are the result of lone individuals feeding on the same carcasses.
  • 2.5K
  • 16 Nov 2022
Topic Review
Pluteus Larva
An echinoderm (/ɪˈkaɪnəˌdɜːrm, ˈɛkə-/) is any member of the phylum Echinodermata (/ɪˌkaɪnoʊˈdɜːrmətə/). The adults are recognisable by their (usually five-point) radial symmetry, and include starfish, brittle stars, sea urchins, sand dollars, and sea cucumbers, as well as the sea lilies or "stone lilies". Adult echinoderms are found on the sea bed at every ocean depth, from the intertidal zone to the abyssal zone. The phylum contains about 7,000 living species, making it the second-largest grouping of deuterostomes, after the chordates. Echinoderms are the largest entirely marine phylum. The first definitive echinoderms appeared near the start of the Cambrian. The echinoderms are important both ecologically and geologically. Ecologically, there are few other groupings so abundant in the biotic desert of the deep sea, as well as shallower oceans. Most echinoderms are able to reproduce asexually and regenerate tissue, organs, and limbs; in some cases, they can undergo complete regeneration from a single limb. Geologically, the value of echinoderms is in their ossified skeletons, which are major contributors to many limestone formations, and can provide valuable clues as to the geological environment. They were the most used species in regenerative research in the 19th and 20th centuries. Further, some scientists hold that the radiation of echinoderms was responsible for the Mesozoic Marine Revolution.
  • 2.5K
  • 28 Nov 2022
Topic Review
Computer-Assisted Audit Tools and Techniques (CAATT)
Computer-Assisted Audit Tools and Techniques (CAATTs) have been generally referred to as technology that assists in audit task completion. There is minimal level of use of CAATTs in developing nations regardless of their importance to audit productivity and cost reduction, and this holds particularly true in the public sector entities’ internal audit departments. 
  • 2.5K
  • 17 Jul 2023
Topic Review
Light-Activated Compounds in Cancer Therapy
Lack of selectivity and toxic side effects of cancer chemotherapy is a major drawback for designing clinical treatment regimes. To allow more potent and selective therapeutic interventions, the use of light for selective on-site activation of anticancer compounds is actively studied. Besides already established photodynamic therapy (PDT), two light-activated anticancer approaches are pursued, both however still in the experimental phase: the use of irreversibly activatable photoremovable protecting groups (“photocages”) and reversibly activatable photoswitches. Despite its immense potential, light activation brings many novel challenges to the already complex drug development process, however the first in vivo results confirm the feasibility of the approach.
  • 2.5K
  • 19 Aug 2021
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