Topic Review
Charlotte's Web (Cannabis)
Charlotte's Web is a high-cannabidiol (CBD), low-tetrahydrocannabinol (THC) Cannabis strain marketed as a dietary supplement under federal law of the United States. It is produced by the Stanley brothers in Colorado. It does not induce the psychoactive "high" typically associated with recreational marijuana strains that are high in THC. In September 2014, the Stanleys announced that they would ensure that the product consistently contained less than 0.3% THC. Charlotte's Web is named after Charlotte Figi, born (2006-10-18) October 18, 2006 (age 16), whose story has led to her being described as "the girl who is changing medical marijuana laws across America." Her parents and physicians say she experienced a reduction of her epileptic seizures brought on by Dravet syndrome after her first dose of medical marijuana at five years of age. Her usage of Charlotte's Web was first featured in the 2013 CNN documentary "Weed". Media coverage increased demand for Charlotte's Web and similar products high in CBD, which has been used to treat epilepsy in toddlers and children. It was originally called "Hippie's Disappointment" as it was a strain that had high CBD and could not induce a "high". While anecdotal reports have sparked interest in treatment with cannabinoids, there is not enough evidence to draw conclusions with certainty about their safety or efficacy. Physicians worry that some parents are willing to try treatments before proper research has been conducted, and that they may be disappointed. They are "alarmed by parallels to past miracle-cure manias later proved false..." and "...wary of the heightened placebo effect in treatments involving children, when reports of progress depend on the view of parents."
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  • 02 Nov 2022
Topic Review
Thermodynamic Dissipation Theory of Life
The Thermodynamic Dissipation Theory of the Origin and Evolution of Life argues that the escence of the origin of life was the microscopic dissipative structuring under UVC light of organic pigments (now known as the fundamental molecules of life - those common to all three domains) and their proliferation over the entire Earth surface, driven by the thermodynamic imperative of dissipating this part of the Archean solar spectrum into heat. With time, dissipative structuring led to ever more complex biosynthetic pathways for creating pigments and their support structures (and processes) which could dissipate not only the UVC region but also other UV regions and the visible wavelengths, until today reaching the "red edge" (at approximately 700 nm). The heat of dissipation of photons absorbed on organic pigments in water then catalyzes a host of coupled secondary dissipative processes such as; the water cycle, ocean and wind currents, hurricanes, etc. pushing the limit for dissipation of the incident light even further towards the infrared. The thermodynamic dissipation theory thus assgins an explicit thermodynamic function to life; the dissipative structuring, proliferation, and evolution of molecular pigments and their complexes from common precursor carbon based molecules under the impressed short wavelength solar photon potential to perform the explicit thermodynamic function of dissipating this light into long wavelength infrared light (heat). In a general sense, the origin of life is no different than the origin of other dissipative structuring processes like hurricanes and the water cycle, except that these latter processes deal with structuring involving hydrogen bonding while life deals with structuring involving covalent bonding. The external photon potential supplied continuously by the environment (our Sun), and its dissipation into heat by the assembly of dissipative structures, are, therefore, both integral components necessary for understanding life. Difficult problems related to the origin of life, such as enzyme-less replication of RNA and DNA, homochirality of the fundamental molecules, and the origin of amino acid -codon assignments (information encoding in RNA and DNA), also find simple explanations within this same dissipative thermodynamic framework once the existence of a relation between primordial RNA and DNA replication and UV-C photon dissipation is established.
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  • 04 Feb 2021
Topic Review
Plasma
Plasma (from grc πλάσμα (plásma) 'moldable substance') is one of the four fundamental states of matter. It contains a significant portion of charged particles – ions and/or electrons. The presence of these charged particles is what primarily sets plasma apart from the other fundamental states of matter. It is the most abundant form of ordinary matter in the universe, being mostly associated with stars, including the Sun. It extends to the rarefied intracluster medium and possibly to intergalactic regions. Plasma can be artificially generated by heating a neutral gas or subjecting it to a strong electromagnetic field. The presence of charged particles makes plasma electrically conductive, with the dynamics of individual particles and macroscopic plasma motion governed by collective electromagnetic fields and very sensitive to externally applied fields. The response of plasma to electromagnetic fields is used in many modern technological devices, such as plasma televisions or plasma etching. Depending on temperature and density, a certain amount of neutral particles may also be present, in which case plasma is called partially ionized. Neon signs and lightning are examples of partially ionized plasmas. Unlike the phase transitions between the other three states of matter, the transition to plasma is not well defined and is a matter of interpretation and context. Whether a given degree of ionization suffices to call a substance 'plasma' depends on the specific phenomenon being considered.
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  • 25 Nov 2022
Topic Review
Fixed Exchange-Rate System
A fixed exchange rate, sometimes called a pegged exchange rate, is a type of exchange rate regime in which a currency's value is fixed against either the value of another single currency to a basket of other currencies or to another measure of value, such as gold. There are benefits and risks to using a fixed exchange rate. A fixed exchange rate is typically used to stabilize the value of a currency by directly fixing its value in a predetermined ratio to a different, more stable, or more internationally prevalent currency (or currencies) to which the value is pegged. In doing so, the exchange rate between the currency and its peg does not change based on market conditions, unlike flexible exchange regime. This makes trade and investments between the two currency areas easier and more predictable and is especially useful for small economies that borrow primarily in foreign currency and in which external trade forms a large part of their GDP. A fixed exchange-rate system can also be used to control the behavior of a currency, such as by limiting rates of inflation. However, in doing so, the pegged currency is then controlled by its reference value. As such, when the reference value rises or falls, it then follows that the value(s) of any currencies pegged to it will also rise and fall in relation to other currencies and commodities with which the pegged currency can be traded. In other words, a pegged currency is dependent on its reference value to dictate how its current worth is defined at any given time. In addition, according to the Mundell–Fleming model, with perfect capital mobility, a fixed exchange rate prevents a government from using domestic monetary policy to achieve macroeconomic stability. In a fixed exchange-rate system, a country’s central bank typically uses an open market mechanism and is committed at all times to buy and/or sell its currency at a fixed price in order to maintain its pegged ratio and, hence, the stable value of its currency in relation to the reference to which it is pegged. To maintain a desired exchange rate, the central bank during the depreciation of the domestic money, sells its foreign money in the reserves and buys back the domestic money. This creates an artificial demand for the domestic money, which increases its exchange rate. In case of an undesired appreciation of the domestic money, the central bank buys back the foreign money and thus flushes the domestic money into the market for decreasing the demand and exchange rate. The central bank from its reserves also provides the assets and/or the foreign currency or currencies which are needed in order to finance any imbalance of payments. In the 21st century, the currencies associated with large economies typically do not fix or peg exchange rates to other currencies. The last large economy to use a fixed exchange rate system was the People's Republic of China, which, in July 2005, adopted a slightly more flexible exchange rate system, called a managed exchange rate. The European Exchange Rate Mechanism is also used on a temporary basis to establish a final conversion rate against the euro from the local currencies of countries joining the Eurozone.
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  • 02 Nov 2022
Topic Review
Ascorbic Acid-Induced Reactions
Ascorbic acid is the most well-known vitamin found in different types of food. It has tremendous medical applications in several different fields such as in pharmaceuticals, cosmetics, and in organic synthesis. Ascorbic acid can be used as a substrate or mediator in organic synthesis. In this review, we report ascorbic acid-catalyzed reactions in organic synthesis. Several examples are included in this review to demonstrate that ascorbic acid is a versatile catalyst for the synthesis of diverse organic compounds. Reactions catalyzed by ascorbic acid are performed in organic or aqueous media. The readily available and easy handling features of ascorbic acid make these procedures highly fascinating.
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  • 25 Nov 2020
Topic Review
Histopathology of Colorectal Carcinoma
The histopathology of colorectal carcinoma involves analysis of tissue taken from a biopsy or surgery. A pathology report contains a description of the microscopical characteristics of the tumor tissue, including both tumor cells and how the tumor invades into healthy tissues and finally if the tumor appears to be completely removed. The most common form of colon cancer is adenocarcinoma, constituting between 95% to 98% of all cases of colorectal cancer. Other, rarer types include lymphoma, adenosquamous and squamous cell carcinoma. Some subtypes have been found to be more aggressive.
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  • 09 Nov 2022
Topic Review
Key Oil Palm Pests and Their Managements
Oil palm, Elaeis guineensis Jacq. (Arecales: Arecaceae), is a multipurpose plantation crop that is extensively grown in the humid tropics across Asia, Africa and the Americas for palm oil and other uses such as sauces, soap, wine, fertilizer (ashes), roofing (leaves), building material (trunk), medicines (roots), and ornamental purposes. Oil palm is attacked by numerous insect species globally, including defoliators, leaf/fruit scrapers, borers and sap feeders. The common oil palm pest management methods include synthetic insecticides, biopesticides, semiochemical lures, cultural practices, and integrated approaches.
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  • 04 Jan 2023
Topic Review Peer Reviewed
Two-Lane Highways: Indispensable Rural Mobility
Two-lane highways refer to roadways consisting of two lanes in the cross section, one for each direction of travel. Occasionally, passing lanes may be added to one or two sides of the roadway extending the cross section to three or four lanes at those locations. In this entry, two-lane highways strictly refer to roads in rural areas meeting the previous definition and do not include urban and suburban streets.
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  • 13 Apr 2022
Topic Review
BM-30 Smerch
The BM-30 Smerch (Russian: Смерч, "tornado", "whirlwind"), 9K58 Smerch or 9A52-2 Smerch-M is a Soviet heavy multiple rocket launcher. The system is intended to defeat personnel, armored, and soft targets in concentration areas, artillery batteries, command posts and ammunition depots. It was designed in the early 1980s and entered service in the Soviet Army in 1989. When first observed by the West in 1983, it received the code MRL 280mm M1983. It is expected to be superseded by the 9A52-4 Tornado.
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  • 15 Nov 2022
Topic Review
Copper-Based Conductive Inks
Silver (Ag), gold (Au), and copper (Cu) have been utilized as metals for fabricating metal-based inks/pastes for printed/flexible electronics. Among them, Cu is the most promising candidate for metal-based inks/pastes. Cu has high intrinsic electrical/thermal conductivity, which is more cost-effective and abundant, as compared to Ag. Moreover, the migration tendency of Cu is less than that of Ag. Thus, recently, Cu-based inks/pastes have gained increasing attention as conductive inks/pastes for printed/flexible electronics. We can divide Cu-based inks/pastes into four categories from the viewpoints of Cu sources: (i) traditional micron-sized flake/powder type, (ii) nanoparticle type, (iii) nanowire type, and (iv) precursor ion type. However, the disadvantages of Cu-based inks/pastes are their instability against oxidation under an ambient condition and tendency to form insulating layers of Cu oxide, such as cuprous oxide (Cu2O) and cupric oxide (CuO). The formation of the Cu oxidation causes a low conductivity in sintered Cu films and interferes with the sintering of Cu particles. The surface and interface designs for Cu-based conductive inks/pastes are important strategies for the oxidation resistance of Cu and low-temperature sintering to produce highly conductive Cu patterns/electrodes on flexible substrates. The surface control approaches include surface designs by polymers, small ligands, core-shell structures, and surface activation. The Cu-based mixed inks/pastes offer improved performances compared with the single use of each component.
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  • 07 Sep 2020
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