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Topic Review
Universal Model of Cancer Transformation and Development
As a phenomenon, cancer is a disease related to multicellular evolution, i.e., cancer in general is understood to be a failure of the multicellular systems and is considered a reversal to unicellularity. Cancer cells are like unicellular organisms that benefit from ancestral-like traits. As a disease, cancer can be interpreted as (a) a destruction of cooperative behaviors underlying multicellular evolution, (b) a disruption of molecular networks established during the emergence of multicellularity or (c) an atavistic state resulting from reactivation of primitive programs typical of the earliest unicellular species. From this point of view and in accordance with the layered model of evolution of cellular functionalities, cancer transformation can occur as a result of huge disturbances or the destruction of functionalities that are located in the multicellular layer.
  • 3.9K
  • 06 May 2022
Topic Review
Fish Pathology
One of the main constraints in aquaculture production is farmed fish vulnerability to diseases due to husbandry practices or external factors like pollution, climate changes, or even the alterations in the dynamic of product transactions in this industry. It is though important to better understand and characterize the intervenients in the process of a disease outbreak as these lead to huge economical losses in aquaculture industries. High-throughput technologies like proteomics can be an important characterization tool especially in pathogen identification and the virulence mechanisms related to host-pathogen interactions on disease research and diagnostics that will help to control, prevent, and treat diseases in farmed fish. Proteomics' important role is also maximized by its holistic approach to understanding pathogenesis processes and fish responses to external factors like stress or temperature making it one of the most promising tools for fish pathology research.
  • 3.9K
  • 28 Jan 2021
Topic Review
Compact Cassette
The Compact Audio Cassette (CAC) or Musicassette (MC), also commonly called the cassette tape or simply tape or cassette, is an analog magnetic tape recording format for audio recording and playback. It was developed by Philips in Hasselt, Belgium, and released in 1962. Compact cassettes come in two forms, either already containing content as a prerecorded cassette, or as a fully recordable "blank" cassette. Both forms are reversible by the user. The compact cassette technology was originally designed for dictation machines, but improvements in fidelity led the Compact Cassette to supplant the Stereo 8-track cartridge and reel-to-reel tape recording in most non-professional applications. Its uses ranged from portable audio to home recording to data storage for early microcomputers. The first cassette player (although mono) designed for use in car dashboards was introduced in 1968. Between the early 1970s and the early 2000s, the cassette was one of the two most common formats for prerecorded music, first alongside the LP record and later the compact disc (CD). Compact Cassettes contain two miniature spools, between which the magnetically coated, polyester-type plastic film (magnetic tape) is passed and wound. These spools and their attendant parts are held inside a protective plastic shell which is 4 by 2.5 by 0.5 inches (10 cm × 6.3 cm × 1.3 cm) at its largest dimensions. The tape itself was commonly referred to as "eighth-inch" tape, supposedly ​1⁄8 inches wide, but it was slightly larger: 0.15 inches (3.81 mm). Two stereo pairs of tracks (four total) or two monaural audio tracks are available on the tape; one stereo pair or one monophonic track is played or recorded when the tape is moving in one direction and the second (pair) when moving in the other direction. This reversal is achieved either by flipping the cassette, or by the reversal of tape movement ("auto-reverse") when the mechanism detects that the tape has come to an end.
  • 3.9K
  • 18 Oct 2022
Topic Review
Pan-Tompkins Algorithm
The Pan-Tompkins algorithm is commonly used to detect QRS complexes in electrocardiographic signals (ECG). The QRS complex represents the ventricular depolarization and the main spike visible in an ECG signal (see figure). This feature makes it particularly suitable for measuring heart rate, the first way to assess the heart health state. In the first derivation of Einthoven of a physiological heart, the QRS complex is composed by a downward deflection (Q wave), an high upward deflection (R wave) and a final downward deflection (S wave). The Pan-Tompkins algorithm applies a series of filters to highlight the frequency content of this rapid heart depolarization and removes the background noise. Then, it squares the signal to amplify the QRS contribute. Finally, it applies adaptive thresholds to detect the peaks of the filtered signal. The algorithm was proposed by Jiapu Pan and Willis J. Tompkins in 1985, in the journal IEEE Transactions on Biomedical Engineering . The performance of the method was tested on an annotated arrhythmia database (MIT/BIH) and evaluated also in presence of noise. Pan and Tompkins reported that the 99.3 percent of QRS complexes was correctly detected.
  • 3.9K
  • 24 Oct 2022
Topic Review
Sesquiterpene Lactones
Sesquiterpene lactones, a vast group of terpenoids isolated from Asteraceae family species, exhibit a wide variety of biological activities and several of them are already available on the medicines market, such as artemisinin. Here are presented and discussed the most recent and impactful results in vivo, preclinical and clinical studies, involving a selection of ten sesquiterpene lactones (alantolactone, arglabin, costunolide, cynaropicrin, helenalin, inuviscolide, lactucin, parthenolide, thapsigargin and tomentosin) and some of their derivatives.
  • 3.9K
  • 28 Oct 2020
Topic Review
Corynebacterium
Corynebacterium species are frequent constituents of the normal bacterial flora of the conjunctival sac and are common as well on human skin and mucous membranes and in the intestines.
  • 3.9K
  • 18 Mar 2021
Topic Review
Rural Tourism Destination
Rural tourism is considered a high potential form of tourism, enhanced by the demand for more sustainable and nature-based solutions, and able to contribute to territory resilience. A rural area is not necessarily a tourist destination, but it might become one, if agricultural enterprises are willing to diversify their economic activities by investing in rural tourism, and local actors provide active support and co-participation.
  • 3.9K
  • 05 Jan 2022
Topic Review
Polycaprolactone-Based Biocomposites
The developments within the topic of biomaterials has taken hold of researchers due to the mounting concern of current environmental pollution as well as scarcity resources. Amongst all compatible biomaterials, polycaprolactone (PCL) is deemed to be a great potential biomaterial, especially to the tissue engineering sector, due to its advantages, including its biocompatibility and low bioactivity exhibition. The commercialization of PCL is deemed as infant technology despite of all its advantages. This contributed to the disadvantages of PCL, including expensive, toxic, and complex.
  • 3.9K
  • 10 Feb 2022
Topic Review
Fascist Syndicalism
Fascist syndicalism (related to national syndicalism) was a trade syndicate movement (syndicat means trade union in French) that rose out of the pre-World War II provenance of the revolutionary syndicalism movement led mostly by Edmondo Rossoni, Sergio Panunzio, A. O. Olivetti, Michele Bianchi, Alceste De Ambris, Paolo Orano, Massimo Rocca, and Guido Pighetti, under the influence of Georges Sorel, who was considered the “‘metaphysician’ of syndicalism.” The Fascist Syndicalists differed from other forms of fascism in that they generally favored class struggle, worker-controlled factories and hostility to industrialists, which lead historians to portray them as “leftist fascist idealists” who “differed radically from right fascists.” Generally considered one of the more radical Fascist syndicalists in Italy, Rossoni was the “leading exponent of fascist syndicalism.”, and sought to infuse nationalism with “class struggle.”
  • 3.9K
  • 20 Oct 2022
Topic Review
Starch Modification
Currently, new methods for producing starch citrates with improved functional and rheological properties while maintaining the highest possible content of resistant starch are being sought. The entry presents an overview of recent studies on the production, properties. And applicability of starch citrates with special attention paid to their role as preparations of resistant starch (RS). The use of citric acid for modification of starch is better for the technology process, while using cross-linking is better than simply using esterification.It may be concluded that the work on starch citrate esters represent a topical and meaningful direction of investigations on modified starch preparations. The possibility of modifying starch preparations by esterification/cross-linking with citric acid allows for the production of modified starch, which can be used in the pharmaceutical, packaging, or food industries. Especially significant may be investigations of resistant starch produced via esterification with citric acid because this method produces preparations exhibiting significant resistance and, simultaneously, good functional properties, which are potentially applicable as health-promoting additives that increase the dietary fiber content of food products.
  • 3.9K
  • 27 Oct 2020
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