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Topic Review
Okra
Okra (Abelmoschus esculentus L.) is a popular vegetable crop with good nutritional significance, along with certain therapeutic values, which makes it a potential candidate in the use of a variety of nutraceuticals.
  • 4.2K
  • 16 Mar 2021
Topic Review
Aquaporin Inhibitors
Aquaporins (AQPs) are water channel proteins that are essential to life, being expressed in all kingdoms. In humans, there are 13 AQPs, at least one of which is found in every organ system. The structural biology of the AQP family is well-established and many functions for AQPs have been reported in health and disease. AQP expression is linked to numerous pathologies including tumor metastasis, fluid dysregulation, and traumatic injury. The targeted modulation of AQPs therefore presents an opportunity to develop novel treatments for diverse conditions. Various techniques such as video microscopy, light scattering and fluorescence quenching have been used to test putative AQP inhibitors in both AQP-expressing mammalian cells and heterologous expression systems. The inherent variability within these methods has caused discrepancy and many molecules that are inhibitory in one experimental system (such as tetraethylammonium, acetazolamide, and anti-epileptic drugs) have no activity in others. Some heavy metal ions (that would not be suitable for therapeutic use) and the compound, TGN-020, have been shown to inhibit some AQPs. Clinical trials for neuromyelitis optica treatments using anti-AQP4 IgG are in progress. However, these antibodies have no effect on water transport. More research to standardize high-throughput assays is required to identify AQP modulators for which there is an urgent and unmet clinical need.
  • 4.2K
  • 06 Sep 2021
Topic Review
Proton–Proton Chain
The proton–proton chain, also commonly referred to as the p-p chain, is one of two known sets of nuclear fusion reactions by which stars convert hydrogen to helium. It dominates in stars with masses less than or equal to that of the Sun, whereas the CNO cycle, the other known reaction, is suggested by theoretical models to dominate in stars with masses greater than about 1.3 times that of the Sun. In general, proton–proton fusion can occur only if the kinetic energy (i.e. temperature) of the protons is high enough to overcome their mutual electrostatic repulsion. In the Sun, deuterium-producing events are rare. Diprotons are the much more common result of proton–proton reactions within the star, and diprotons almost immediately decay back into two protons. Since the conversion of hydrogen to helium is slow, the complete conversion of the hydrogen initially in the core of the Sun is calculated to take more than ten billion years. Although sometimes called the "proton–proton chain reaction", it is not a chain reaction in the normal sense. In most nuclear reactions, a chain reaction designates a reaction that produces a product, such as neutrons given off during fission, that quickly induces another such reaction. The proton-proton chain is, like a decay chain, a series of reactions. The product of one reaction is the starting material of the next reaction. There are two main chains leading from Hydrogen to Helium in the Sun. One chain has five reactions, the other chain has six.
  • 4.2K
  • 10 Nov 2022
Topic Review
Composite Material Applications
Composite materials are composed of two or more different materials having considerably different physical and/or chemical characteristics that, when merged, produce a material with attributes that differ from the separate elements. Composite materials are extensively utilized in the automobile, construction, transportation, aerospace, and renewable energy applications due to their durability, high strength, great quality, minimal maintenance, and low weight.
  • 4.2K
  • 08 Oct 2021
Topic Review
Sustainability Green Industry 4.0
The Sustainability Green Industry (SGI) 4.0 framework captures the relations of Industry 4.0, green processes and sustainability in manufacturing. The framework is structured into three vertical levels: technological, process and development, integrated through the circular economy. The SGI 4.0 framework’s purpose is to explain how Industry 4.0 technologies create sustainability outcomes through green processes. The facilitating, enabling and supporting functions of green processes allow to understand how modern technologies can be linked to the concept of sustainability. In the literature we can find various concepts connecting Industry 4.0 and sustainability, however, the key role of green processes is not mentioned.
  • 4.2K
  • 25 Jun 2021
Topic Review
Barrier Layer of Cu Interconnects
The barrier layer in Cu technology is essential to prevent Cu from diffusing into the dielectric layer at high temperatures; therefore, it must have a high stability and good adhesion to both Cu and the dielectric layer. In the past three decades, tantalum/tantalum nitride (Ta/TaN) has been widely used as an inter-layer to separate the dielectric layer and the Cu. However, to fulfill the demand for continuous down-scaling of the Cu technology node, traditional materials and technical processes are being challenged. Direct electrochemical deposition of Cu on top of Ta/TaN is not realistic, due to its high resistivity. Therefore, pre-deposition of a Cu seed layer by physical vapor deposition (PVD) or chemical vapor deposition (CVD) is necessary, but the non-uniformity of the Cu seed layer has a devastating effect on the defect-free fill of modern sub-20 or even sub-10 nm Cu technology nodes. New Cu diffusion barrier materials having ultra-thin size, high resistivity and stability are needed for the successful super-fill of trenches at the nanometer scale. In this review, we briefly summarize recent advances in the development of Cu diffusion-proof materials, including metals, metal alloys, self-assembled molecular layers (SAMs), two-dimensional (2D) materials and high-entropy alloys (HEAs). Also, challenges are highlighted and future research directions are suggested.
  • 4.2K
  • 30 Jul 2021
Topic Review
Megafaunal Wolf
The megafaunal wolf (Canis cf. lupus) was a Late Pleistocene – early Holocene hypercarnivore similar in size to a large extant gray wolf. It had a shorter, broader palate with large carnassial teeth relative to its overall skull size. This adaptation allowed it to prey and scavenge on Pleistocene megafauna. Such an adaptation is an example of phenotypic plasticity. It was once distributed across the northern Holarctic.
  • 4.2K
  • 23 Nov 2022
Topic Review
Mercedes-Benz W114
The Mercedes-Benz W114 and W115 models are a series of executive sedans and coupés introduced in 1968 by Mercedes-Benz, manufactured through model year 1976, and distinguished in the marketplace by names relating to their engine size. W114 models featured six-cylinder engines and were marketed as the 230, 250, and 280, while W115 models featured four-cylinder engines and were marketed as the 200, 220, 230, and 240. All were styled by Paul Bracq, featuring a three-box design. At the time Mercedes marketed sedans in two size classes, with the W114/W115 positioned below the Mercedes-Benz S-Class. Beginning in 1968, Mercedes marketed their model range as New Generation Models, giving their ID plates the designation '/8' (due to their 1968 Launch year). Because they were the only truly new cars of the so-called 'New Generation' and because of the '/8' or 'slash eight' designation, W114 and W115 models ultimately received the German nickname Strich Acht, loosely translated into the English stroke eight.
  • 4.2K
  • 04 Nov 2022
Topic Review
Tomato Fruit and its Colors
Fruit colour represents a genetic trait with ecological and nutritional value. Plants mainly use colour to attract animals and favour seed dispersion. Thus, in many species, fruit colour coevolved with frugivories and their preferences. Environmental factors, however, represented other adaptive forces and further diversification was driven by domestication. All these factors cooperated in the evolution of tomato fruit, one of the most important in human nutrition. Tomato phylogenetic history showed two main steps in colour evolution: the change from green-chlorophyll to red-carotenoid pericarp, and the loss of the anthocyanic pigmentation. These events likely occurred with the onset of domestication. Then spontaneous mutations repeatedly occurred in carotenoid and phenylpropanoid pathways, leading to colour variants which often were propagated. Introgression breeding further enriched the panel of pigmentation patterns.
  • 4.2K
  • 30 Sep 2021
Topic Review
The Fibrosis-4 (FIB-4) Index
The fibrosis-4 (FIB-4) index is the first triaging tool for excluding advanced fibrosis because of its accuracy, simplicity, and cheapness, especially for general physicians or endocrinologists, although the FIB-4 index has several drawbacks. Accumulating evidence has suggested that vibration-controlled transient elastography (VCTE) and the enhanced liver fibrosis (ELF) test may become useful as the second step after triaging by the FIB-4 index. The leading cause of mortality in MAFLD is cardiovascular disease (CVD), extrahepatic malignancy, and liver-related diseases. MAFLD often complicates chronic kidney disease (CKD), resulting in increased simultaneous liver kidney transplantation. The FIB-4 index could be a predictor of not only liver-related mortality and incident hepatocellular carcinoma, but also prevalent and incident CKD, CVD, and extrahepatic malignancy.
  • 4.2K
  • 25 May 2021
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