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Topic Review
Commercial Targeted Libraries in Drug Design
After the identification of a biological target (enzyme, receptor, protein and so on), the focus of the early phase of drug discovery rests on the identification of leads or compounds that exhibit pharmacological activity against this specific target. Compounds of interest are most often discovered in pre-existing libraries of compounds that can be either virtual or physical. Computer-aided methods which have become increasingly important over the years in drug development utilize virtual compound libraries. While physical compound libraries reach the number of millions of molecules, virtual compound libraries created by large pharmaceutical companies can range from 107 to 1018 molecules. Investigations of these libraries identifies specific molecules, synthetic pathways and focus on a specific chemical space. Targeted libraries are often smaller and are focused towards a specific chemical space. They are created by using relevant biological information with the aim to decrease the processing time associated with larger libraries while maintaining the most relevant chemical space where lead compounds can be found. Due to the fact that they required less computational or wet-lab labor to process they have become very popular with smaller laboratories which try to compete in the drug-development sector. Many modern vendors of compounds today offer such libraries, but the quality of the procedure used to define desired chemical space and select compounds is questionable.
  • 1.1K
  • 25 May 2022
Topic Review
Journal Axioms
Axioms (ISSN 2075-1680) is an international, peer-reviewed, open access journal of mathematics, mathematical logic and mathematical physics, published quarterly online by MDPI. It's now indexed within SCIE (Web of Science), Scopus, dblp, and other databases.
  • 1.1K
  • 26 Sep 2021
Topic Review
Deep Learning Based Object Detection
Object detection is a complex problem due to underlying high intra-class and low inter-class variance. High intra-class variance is the consequence of different objects belonging to a single class, for instance, different poses of humans or humans wearing different clothes in an image. Low inter-class variance is the outcome of similar-looking objects belonging to different classes such as samples of class chair can easily be misclassified into the class bench and vice versa.
  • 1.1K
  • 31 Aug 2021
Topic Review
IBM Hexadecimal Floating Point
IBM System/360 computers, and subsequent machines based on that architecture (mainframes), support a hexadecimal floating-point format (HFP). In comparison to IEEE 754 floating-point, the IBM floating-point format has a longer significand, and a shorter exponent. All IBM floating-point formats have 7 bits of exponent with a bias of 64. The normalized range of representable numbers is from 16−65 to 1663 (approx. 5.39761 × 10−79 to 7.237005 × 1075). The number is represented as the following formula: (−1)sign × 0.significand × 16exponent−64.
  • 1.1K
  • 09 Oct 2022
Topic Review
Science, Technology, Engineering, and Mathematics
Science, technology, engineering, and mathematics (STEM) is a broad term used to group together these academic disciplines. This term is typically used to address an education policy or curriculum choices in schools. It has implications for workforce development, national security concerns (as a shortage of STEM-educated citizens can reduce effectiveness in this area) and immigration policy. There is no universal agreement on which disciplines are included in STEM; in particular whether or not the science in STEM includes social sciences, such as psychology, sociology, economics, and political science. In the United States, these are typically included by organizations such as the National Science Foundation (NSF). The National Science Foundation deals with all matters concerning science and new discoveries in science as it affects development, research, and innovations, the Department of Labor's O*Net online database for job seekers, and the Department of Homeland Security. In the United Kingdom, the social sciences are categorized separately and are instead grouped together with humanities and arts to form another counterpart acronym HASS (Humanities, Arts, and Social Sciences), rebranded in 2020 as SHAPE (Social Sciences, Humanities and the Arts for People and the Economy).
  • 1.1K
  • 14 Nov 2022
Topic Review
Dingbat
In typography, a dingbat (sometimes more formally known as a printer's ornament or printer's character) is an ornament, specifically, a glyph used in typesetting, often employed to create box frames, (similar to box-drawing characters) or as a dinkus (section divider). Some of the dingbat symbols have been used as signature marks, used in bookbinding to order sections. In the computer industry, a Dingbat font was a computer font that has symbols and shapes that reused the code points designated for alphabetical or numeric characters. This practice was necessitated by the limited number of code points available in 20th century operating systems. Most modern fonts are based on Unicode, which has unique code points for dingbat glyphs.
  • 1.1K
  • 25 Nov 2022
Topic Review
Spatial-Frequency Domain Imaging
Measurement of optical properties is critical for understanding light-tissue interaction, properly interpreting measurement data, and gaining better knowledge of tissue physicochemical properties. However, conventional optical measuring techniques are limited in point measurement, which partly hinders the applications on characterizing spatial distribution and inhomogeneity of optical properties of biological tissues. Spatial-frequency domain imaging (SFDI), as an emerging non-contact, depth-varying and wide-field optical imaging technique, is capable of measuring the optical properties in a wide field-of-view on a pixel-by-pixel basis. 
  • 1.1K
  • 01 Jun 2021
Topic Review
Yahoo Sports
Yahoo Sports is a sports news website launched by Yahoo! on December 8, 1997. It receives a majority of its information from STATS, Inc. It employs numerous writers, and has team pages for teams in almost every North American major sport. Before the launch of Yahoo Sports, certain elements of the site were known as Yahoo! Scoreboard. From 2011 to 2016, the Yahoo Sports brand had also been used for a U.S. sports radio network. That network is now known as SportsMap.
  • 1.1K
  • 08 Nov 2022
Topic Review
AI-Based Wormhole Attack Detection Techniques
The popularity of wireless sensor networks for establishing different communication systems is increasing daily. A wireless network consists of sensors prone to various security threats. These sensor nodes make a wireless network vulnerable to denial-of-service attacks. One of them is a wormhole attack that uses a low latency link between two malicious sensor nodes and affects the routing paths of the entire network. This attack is brutal as it is resistant to many cryptographic schemes and hard to observe within the network. 
  • 1.1K
  • 12 Aug 2022
Topic Review
Oracle Policy Automation
Oracle Policy Automation (abbreviated OPA) is a suite of software products for modeling and deploying business rules within enterprise applications. Oracle Corporation acquired OPA in December 2008 when it purchased Australian software company RuleBurst Holdings, then trading as Haley. Oracle Policy Automation was designed by RuleBurst to transform legislation and policy documents into executable business rules, particularly for the calculation of benefit entitlements and payment amounts. Although OPA was originally developed for and sold to the public sector, it can be used in other industries. Oracle Policy Automation continues to be available as a standalone offering and an integrated rules solution for SAP and Siebel.
  • 1.1K
  • 16 Nov 2022
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