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Topic Review
Gene Circuits for Cancer Immunotherapy
Engineered mammalian cells for medical purposes are becoming a clinically relevant reality thanks to advances in synthetic biology that allow enhanced reliability and safety of cell-based therapies. However, their application is still hampered by challenges including time-consuming design-and-test cycle iterations and costs. For example, in the field of cancer immunotherapy, CAR-T cells targeting CD19 have already been clinically approved to treat several types of leukemia, but their use in the context of solid tumors is still quite inefficient, with additional issues related to the adequate quality control for clinical use.
  • 669
  • 17 Jan 2021
Biography
Gene Haas
Eugene "Gene" Francis Haas (born November 12, 1952) is founder, president, and sole stockholder of Haas Automation, a CNC machine tool manufacturer. He also has a presence in motorsports, having founded NASCAR team Haas CNC Racing (now known as Stewart-Haas Racing) and the Formula One team, Haas F1 Team. Haas graduated from California State University Northridge in 1975 with a Bachelor of Sci
  • 536
  • 29 Nov 2022
Topic Review
Gene-Editing Technology of Zebrafish
As a vertebrate model, zebrafish (Danio rerio) plays a vital role in the field of life sciences. Recently, gene-editing technology has become increasingly innovative, significantly promoting scientific research on zebrafish. However, the implementation of these methods in a reasonable and accurate manner to achieve efficient gene-editing remains challenging.
  • 497
  • 08 Sep 2021
Topic Review
General Aircraft Hamilcar
The General Aircraft Limited GAL. 49 Hamilcar or Hamilcar Mark I was a large United Kingdom military glider produced during the Second World War, which was designed to carry heavy cargo, such as the Tetrarch or M22 Locust light tank. When the British airborne establishment was formed in 1940 by the order of Prime Minister Winston Churchill it was decided to develop a large glider which would be able to transport heavy equipment in support of airborne troops. General Aircraft Limited were chosen in January 1941 to develop this glider, which they designated the GAL. 49 'Hamilcar'. It was designed to transport a single light tank or two Universal Carriers. A number of problems, which included vacillation by the War Office on the number of gliders that it wanted and poor management by GAL, led to delays in the production of the Hamilcar, and the first production glider was only assembled in mid-1943. These problems were only partially solved, and production of the glider continued to be slow, hampered by difficulties in finding suitable locations to store and construct the Hamilcars once their parts were produced. A total of 344 Hamilcars had been built when production ended in 1946. Hamilcars were only used on three occasions, and only in support of British airborne forces. They first saw action in June 1944, when approximately thirty were used to carry 17-pounder anti-tank guns, transport vehicles and Tetrarch light tanks into Normandy in support of British airborne forces during Operation Tonga. In September 1944 a similar number of Hamilcars were used to transport anti-tank guns, transport vehicles and supplies for airborne troops as part of Operation Market Garden. They were used a third and final time in March 1945 during Operation Varsity, when they transported M22 Locust light tanks and other supplies. The gliders proved to be successful in all three operations, although their slow speed and large size made them easy targets for anti-aircraft fire, which resulted in a number of gliders being damaged or destroyed. A powered variant of the Hamilcar was produced, the Hamilcar Mark X, in an attempt to extend the range of the Hamilcar so it could serve in the Pacific War; however, the conflict in the Pacific ended before the design could see combat.
  • 484
  • 31 Oct 2022
Topic Review
General Atomics Avenger
The General Atomics Avenger (formerly Predator C) is a developmental unmanned combat air vehicle built by General Atomics Aeronautical Systems for the U.S. military.
  • 1.6K
  • 03 Nov 2022
Topic Review
General Performance of Pressure Wave Supercharger
One main direction in improving the efficiency of an internal combustion engine, together with lowering the emissions, is supercharging, i.e., creating a considerable amount of boost for the inlet combustion air. Turbochargers are the most commonly used for this task, but another advantageous alternative exploiting the energy within exhaust gases is the pressure wave supercharger (PWS).
  • 1.6K
  • 21 Apr 2022
Topic Review
General Theory of Photodetectors
Photodetectors are one of the popular types of technology used in ultraviolet radiation research. They are widely used in the industrial area (flame detectors, fire alarm systems, extreme UV lithography), national security (missile defense, military recognition, explosives detection, forensic analysis, secure communications), in fields such as medicine (UV imaging, protein analysis, and DNA sequencing) or biology (biological agent detection), and when dealing with environmental issues (ozone detection, air pollution determination, disinfection, and decontamination).
  • 834
  • 19 May 2023
Topic Review
Generating Interior Design from Text
Because interior design is subject to inefficiency, more creativity is imperative. Due to the development of artificial intelligence diffusion models, the utilization of text descriptions for the generation of creative designs has become a novel method for solving the aforementioned problem.
  • 660
  • 15 Aug 2023
Topic Review
Generating Point Clouds from FMCW Radar
Radar sensing-based devices, particularly those using Frequency-Modulated Continuous Wave (FMCW), can obtain target information such as distance, angle, moving speed, and target size, making them superior when compared to other non-contact sensing technologies. FMCW technology provides access to a lot of crucial information at an affordable price. It is well suited for different working conditions, making it highly suitable for in-vehicle detection scenarios.
  • 692
  • 04 Jan 2024
Topic Review
Generative Algorithms in Human-Centered Product Development
Algorithmic design harnesses the power of computation to generate a form based on input data and rules. In the product design setting, a major advantage afforded by this approach is the ability to automate the customization of design variations in accordance with the requirements of individual users. The background knowledge, intuition, and critical judgement of the designer are still essential but are focused on different areas of the design process.
  • 492
  • 06 May 2022
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