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Topic Review
Cinnamon, Clove and Cumin against Urinary Tract Infections
Spices are aromatic plants widely used in Mexico to flavor, color, or preserve food. In particular, the Food and Drug Administration (FDA) Organization defined spices as: “whole, broken or ground aromatic vegetable substances, whose significant function in food is to flavor rather than to nourish”. Most of the beneficial health properties of spices are mediated through the direct action of their phytochemicals, especially polyphenols or polyphenol degradation products. These phytochemicals have broad antioxidant properties and target specific receptors or enzymes involved in various anti-inflammatory pathways or immune responses. Phenolic acids and flavonoids, especially flavones and flavonoids, are spices’ predominant class of polyphenols. Furthermore, the antimicrobial properties of spices are attributed to their unique volatile oils and oleoresins. Because spices are obtained from aromatic plants and herbs, they are generally considered safe (GRAS).
  • 18.9K
  • 28 Apr 2023
Biography
René Sotelo
René Sotelo (6 November 1962) is a Venezuelan robotic surgeon, urologist-oncologist and university professor.[1][2] Sotelo received his medical degree from Central University of Venezuela[3] and his residency in General Surgery and Urology was at Domingo Luciani Hospital, Venezuela. He completed fellowship in Urologic Oncology at the Hospital Padre Machado in Caracas, Venezuela; training in
  • 7.1K
  • 18 Nov 2022
Topic Review
Urinary Tract Infections during the COVID-19 Pandemic
The landscape of management of urinary tract infections (UTI) is changing rapidly. The COVID-19 pandemic draws the attention to the SARS-CoV-2 management with a subsequent reduced attention on bacterial infections. The COVID-19 diffusion containing procedures, such as use of facemasks and handwashing, have reduced spreading of bacteria and bacterial lung infections.
  • 2.5K
  • 21 Mar 2022
Topic Review
Bladder Cancer Biomarkers
The high occurrence of bladder cancer and its tendency to recur combined with lifelong surveillance make the treatment of superficial bladder cancer one of the most expensive and time-consuming. Moreover, carcinoma in situ often leads to muscle invasion with an unfavourable prognosis. Currently, invasive methods including cystoscopy and cytology remain a gold standard. The aim is to find biomarkers with the best specificity and sensitivity, allowing the treatment plan to optimise and have potential applications in clinical practice. Such non-invasive methods can be measure in human body fluids, for example, urine or serum: Cytokeratin fragments (CYFRA 21.1), Excision Repair Cross-Complementation 1 (ERCC1), Tumour Protein p53 (Tp53), Fibroblast Growth Factor Receptor 3 (FGFR3), Tumor-Associated Trypsin Inhibitor (TATI).
  • 2.2K
  • 29 Mar 2022
Topic Review
Kidney Failure after Liver Transplantation
One-third of patients with cirrhosis present kidney failure (AKI and CKD). It has multifactorial causes and a harmful effect on morbidity and mortality before and after liver transplantation. Kidney function does not improve in all patients after liver transplantation, and liver transplant recipients are at a high risk of developing chronic kidney disease. The causes of renal dysfunction can be divided into three groups: pre-operative, perioperative and post-operative factors.
  • 2.1K
  • 22 Sep 2021
Topic Review
Hyperfiltration
Hyperfiltration is an important underlying cause of glomerular dysfunction associated with several systemic and intrinsic glomerular conditions leading to chronic kidney disease (CKD). These include obesity, diabetes, hypertension, focal segmental glomerulosclerosis (FSGS), congenital abnormalities and reduced renal mass (low nephron number). Hyperfiltration-associated biomechanical forces directly impact the cell membrane, generating tensile and fluid flow shear stresses in multiple segments of the nephron.
  • 2.0K
  • 01 Mar 2022
Topic Review
Lymphatic Drainage of Renal Tissues
Acute kidney injury (AKI), especially if recurring, represents a risk factor for future chronic kidney disease. In intensive care units, increased intra-abdominal pressure is well-recognized as a significant contributor to AKI. Renal interstitial pressure changes synchronously to renal perfusion pressure. The renal parenchyma is primarily drained by the urine conducting and renal venous system. The renal lymphatic system can also contribute to renal compartment syndrome, the functional changes in the lymphatic flow was not investigated in connection with pneumo-peritoneum.
  • 1.9K
  • 17 May 2022
Topic Review
Urinary Tract Infections
Urinary tract infections (UTIs) affect any part of the urinary tract and may spread through the urinary tract towards the urethra, bladder and even the kidneys and they are associated with an increase in morbidity and mortality. UTIs may be resolved spontaneously or treated with antibiotics. However, regular use of antibiotics is related to nephrotoxicity and  produces changes in the intestinal flora, alter immunity and metabolism, and finally, gut bacteria become a reservoir of genes for resistance to antibiotics. Regarding this concern, a new group of molecules called drug conjugates have been proposed as an alternative or a complement to de use of just antibiotics such as a new adjuvant in UTIs therapy called Itxasol©.
  • 1.8K
  • 11 Oct 2021
Topic Review
Glucose-Lowering Medications in Erectile Dysfunction
Erectile dysfunction (ED) is a common underestimated complication of diabetes mellitus that affects more than 50% of people with diabetes. Diabetes dramatically raises the risk of developing ED by 2.5-fold. Despite that several studies have explained the pathogenetic mechanisms involved in the generation of erectile failure, few studies to date have described the efficacy of glucose-lowering medications in the restoration of normal sexual activity. Herein, we will present current knowledge about the main starters of the pathophysiology of diabetic ED and explore the role of different anti-diabetes therapies in the potential remission of ED, highlighting specific pathways whose activation or inhibition could be fundamental for sexual care in a diabetes setting.
  • 1.7K
  • 28 Jun 2021
Topic Review
Prostate Cancer Liquid Biopsy Biomarkers
Prostate cancer biomarkers can be measured in urine, blood or tissue. A variety of tests that analyse patients' biomarkers have been developed to improve diagnosis, prognosis and to help stratify individual's risk of prostate cancers. Liquid biopsy biomarkers are easy-to-use and non-invasive. They guide the decision-making process, determine whether the patient requires treatment or can be monitored under active surveillance, and help choose the best treatment option.
  • 1.5K
  • 29 Mar 2022
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