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Topic Review
Regulation of P-glycoprotein
P-glycoprotein (Pgp, ABCB1 protein, MDR1) is a transporter protein, the most studied representative of the ABC transporter superfamily. Pgp is an efflux protein: it ensures the outflow of molecules from cells into the extracellular space.
  • 158
  • 26 Feb 2024
Topic Review
Nanovesicles for Enhanced Drug Delivery
Liposomes are the classic and first investigated phospholipid vesicles. These are rigid nanovesicles, and their ability to enhance drug permeability to the deeper skin layers is limited. 
  • 83
  • 22 Feb 2024
Topic Review
Mechanisms of Light-Triggered Drug Release from Liposomes
Light-triggered mechanisms that can be exploited to release encapsulated drugs from liposomes are photoisomerization, photocleavage (photo-oxidation), surface plasmon resonance absorption (photothermal activation), photochemical hydrophobicity change (photochemical activation), and photo-crosslinking and de-crosslinking.
  • 193
  • 18 Feb 2024
Topic Review
The Useful Antiviral Properties of Lysozyme
Lysozyme, especially the one obtained from hen’s egg white, continues to show new pharmacological properties. Lysozyme can interact with nucleic acids and alter their function, but this effect is uncoupled from the catalytic activity that determines its antibacterial activity; it is present in intact lysozyme but is equally potent in a heat-degraded lysozyme or in a nonapeptide isolated by proteolytic digestion.
  • 177
  • 08 Feb 2024
Topic Review
Antimicrobial Properties of Ocimum basilicum, Lamiaceae
Since ancient times, various scientists and doctors have utilized different herbs to heal diseases. Due to the rise in drug resistance and the negative effects of chemosynthetic drugs, researchers and the general public around the world have become more interested in medicinal herbs and plant metabolites/extracts. This is due to its non-toxicity and its several health benefits when used to treat diseases in clinical and medical settings. Ocimum basilicum is one such plant, possessing a wide range of bioactive phytochemicals including alkaloids, phenolics, flavonoids, tannins, saponins, reducing sugars, cardiac glycosides, steroids and glycosides, as well as complex pharmacological activities, including anti-inflammatory, antifungal, antibacterial, antioxidant, wound healing and antiviral properties.
  • 141
  • 07 Feb 2024
Topic Review
Nano-Formulations for Pulmonary Delivery
With the development of nanotechnology and confronting the problems of traditional pharmaceutical formulations in treating lung diseases, inhalable nano-formulations have attracted interest. Inhalable nano-formulations for treating lung diseases allow for precise pulmonary drug delivery, overcoming physiological barriers, improving aerosol lung deposition rates, and increasing drug bioavailability. They are expected to solve the difficulties faced in treating lung diseases. 
  • 88
  • 07 Feb 2024
Topic Review
Bacterial Efflux Pump Inhibitors Reduce Antibiotic Resistance
Efflux pump inhibitors, small molecules capable of restoring the effectiveness of existing antibiotics, are considered potential solutions to antibiotic resistance and have been an active area of research in recent years. Efflux pump inhibitors block efflux pumps through one or more processes, which can inactivate drug transport. 
  • 121
  • 05 Feb 2024
Topic Review
NaDES Application in Cosmetic and Pharmaceutical Fields
Natural deep eutectic solvents (NaDES) represent a new generation of green, non-flammable solvents, useful as an efficient alternative to the well-known ionic liquids. They can be easily prepared and exhibit unexpected solubilizing power for lipophilic molecules, although those of a hydrophilic nature are mostly used. For their unique properties, they can be recommend for different cosmetic and pharmaceutical applications, ranging from sustainable extraction, obtaining ready-to-use ingredients, to the development of biocompatible drug delivery responsive systems. 
  • 95
  • 01 Feb 2024
Topic Review
The Rationale of Hyperthermic Intraperitoneal Chemotherapy Treatment
Peritoneal metastases (PM) are observed in approximately 8% of patients diagnosed with colorectal cancer, either synchronously or metachronously during follow-up. PM often manifests as the sole site of metastasis. PM is associated with a poor prognosis and typically shows resistance to systemic chemotherapy. Consequently, there has been a search for alternative treatment strategies. For intraperitoneal (IP) therapy to exhibit promise, it either needed to be combined with the removal of larger tumor nodules during cytoreductive surgery or administered as repeated intermittent treatments over an extended duration to affect macroscopic tumor nodules. Cytoreductive surgery, with hyperthermic intraperitoneal chemotherapy (HIPEC) treatment as an adjunct, emerged as a solution for the former situation.
  • 87
  • 31 Jan 2024
Topic Review
Curcumin Inorganic Nanoparticles and its Anti-cancer Potential
Curcumin is a natural compound that has been widely investigated thanks to its various biological properties, including antiproliferative. This molecule acts on different cancers such as lung, breast, pancreatic, colorectal, etc. However, the bioactive actions of curcumin have limitations when its physicochemical properties compromise its pharmacological potential. As a therapeutic strategy against cancer, curcumin has been associated with inorganic nanoparticles. These nanocarriers are capable of delivering curcumin and offering physicochemical properties that synergistically enhance anticancer properties. 
  • 105
  • 31 Jan 2024
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