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Topic Review
CAR-T Therapy
Chimeric antigen receptor-T (CAR-T) therapy targeting CD19 has revolutionised the treatment of advanced acute lymphoblastic leukaemia (ALL) and diffuse large B-cell lymphoma (DLBCL). The success of CAR-T therapy in the first two indications led to the initiation of a large number of studies testing CAR-T therapy in different haematologic tumours such as acute myelogenous leukaemia (AML), Hodgkin’s disease (HD), chronic lymphocytic leukaemia (CLL), multiple myeloma (MM), as well as different solid tumours. Notwithstanding, this did not prohibit further development of this new therapy to treat other malignancies.
  • 585
  • 31 May 2021
Topic Review
Cardiac Fibrosis and Fibroblasts
Cardiac fibrosis is the excess deposition of extracellular matrix (ECM), such as collagen.
  • 581
  • 23 Jul 2021
Topic Review
Cardiomyopathies
Cardiomyopathies are defined as cardiac diseases, in which the heart muscle is affected showing functional and structural defects.
  • 1.1K
  • 04 Feb 2021
Topic Review
Cardioprotective Properties of Kaempferol
Cardiac diseases, such as myocardial infarction and heart failure, have become a major clinical problem globally. The accumulating data demonstrate that bioactive compounds with antioxidant and anti-inflammatory properties have favorable effects on clinical problems. Kaempferol is a flavonoid found in various plants; it has demonstrated cardioprotective properties in numerous cardiac injury models. 
  • 116
  • 11 Sep 2023
Biography
Carlos M. Villalón
Carlos M. Villalón was born in Mexico City on November 2, 1959. He completed his studies in Chemistry & Pharmacy (Pharmacist) in 1983 at the National School of Biological Sciences (IPN), and his postgraduate studies at the Department of Pharmacology and Toxicology of Cinvestav (M.Sc. in 1986 and Ph.D. in 1988). Between 1988 and 1991 he did a postdoctoral stay at the Erasmus Universiteit Rotterd
  • 483
  • 18 Jul 2023
Topic Review
Carriers Containing Phospholipid Soft Vesicles
Topical drug delivery has many advantages over other ways of administration, having increased patient compliance, avoiding the first-pass effect following oral drug administration or not requesting multiple doses administration. However, the skin barrier prevents the access of the applied drug, affecting its therapeutic activity. Carriers containing phospholipid soft vesicles are a new approach to enhance drug delivery into the skin and to improve the treatment outcome. These vesicles contain molecules that have the property to fluidize the phospholipid bilayers generating the soft vesicle and allowing it to penetrate into the deep skin layers. Ethosomes, glycerosomes and transethosomes are soft vesicles containing ethanol, glycerol or a mixture of ethanol and a surfactant, respectively. 
  • 490
  • 17 Dec 2021
Topic Review
Cataracts
A cataract is an ophthalmic disorder characterized by the opacification of the lens and occurs commonly in older people. Age-related cataract is a significant cause of blindness affecting the quality of life worldwide. An imbalance between oxidative stress and antioxidant potential of ocular tissue is considered responsible for structural modifications of crystallins, the protein constituents of the lens, which eventually leads to cataracts. Lutein and zeaxanthin are two major carotenoids which are concentrated in the human lens. Many preclinical and clinical studies provide compelling evidence for a protective role of dietary carotenoids in age-related cataracts.
  • 4.2K
  • 28 Sep 2021
Topic Review
Cathinones Mexedrone, α-PVP and α-PHP
Mexedrone, α-PVP and α-PHP are synthetic cathinones. They can be considered amphetamine-like substances with a stimulating effect. Actually, studies showing their impact on DNA are totally absent. 
  • 1.5K
  • 05 Jul 2021
Topic Review
Causes and Risk Factors of Alzheimer’s Disease
Alzheimer’s disease (AD) is a disorder that causes degeneration of the cells in the brain and it is the main cause of dementia, which is characterized by a decline in thinking and independence in personal daily activities. AD is considered a multifactorial disease: two main hypotheses were proposed as a cause for AD, cholinergic and amyloid hypotheses. Additionally, several risk factors such as increasing age, genetic factors, head injuries, vascular diseases, infections, and environmental factors play a role in the disease.
  • 496
  • 29 Feb 2024
Topic Review
CCL-11 or Eotaxin-1
CCL-11 (eotaxin) is a chemokine with an important role in allergic conditions. Recent evidence indicates that CCL-11 plays a role in brain disorders as well. CCL-11 is rapidly transported from the blood to the brain through the blood-brain barrier. Age-related increases in CCL-11 are associated with cognitive impairments in executive functions and episodic and semantic memory, and therefore, this chemokine has been described as an “Endogenous Cognition Deteriorating Chemokine” (ECDC) or “Accelerated Brain-Aging Chemokine” (ABAC).
  • 542
  • 16 Apr 2021
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