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Topic Review
Extraction, Isolation and Characterization of Bioactive Compounds
Diverse medicinal plants such as those from the genus Artemisia have been employed globally for centuries by individuals belonging to different cultures. Universally, Artemisia species have been used to remedy various maladies that range from simple fevers to malaria. 
  • 1.3K
  • 03 Dec 2021
Topic Review
Eysenhardtia genus
The participation of natural products in health care has been remarkable, and today they continue to play a key role in the discovery and development of new treatments. Phytochemical studies together with pharmacological tests have managed to integrate bioactive agents as an alternative solution to reduce or regulate the problems caused by diseases. The Eysenhardtia genus is a family of plants that are rich in secondary metabolites, which have shown potential activity in the control and mitigation of urinary disorders, diabetes, oxidative stress, protein glycosylation, microbial infections, inflammation, pain or discomfort, muscle contractions, cytotoxicity, or as a cellular or neuronal signaling modulator. These conditions generally appear in comorbid diseases, which motivated the bibliographic review associated with the plant. This document presents the beneficial actions produced by Eysenhardtia extracts and/or bioactives to inhibit, control, or reduce the complications or discomfort of degenerative diseases and thus generate new therapeutic alternatives.
  • 453
  • 08 Sep 2020
Topic Review
FAAH, MAGL, and DAGL in Obesity Treatment
The endocannabinoid system (ECS) plays an integral role in maintaining metabolic homeostasis and may affect hunger, caloric intake, and nutrient absorption. Obesity has been associated with higher levels of the endogenous cannabinoid transmitters (endocannabinoids). Therefore, the ECS is an important target in obesity treatment. Modulating the enzymes that synthesize and degrade endocannabinoids, namely fatty acid amide hydrolase (FAAH), monoacylglycerol lipase (MAGL), and diacylglycerol lipase (DAGL), may be a promising strategy to treat obesity.
  • 422
  • 18 Jan 2022
Topic Review
Fabrication and Current Status of Microneedles
One of the most cutting-edge, effective, and least invasive pharmaceutical innovations is the utilization of microneedles (MNs) for drug delivery, patient monitoring, diagnostics, medicine or vaccine delivery, and other medical procedures (e.g., intradermal vaccination, allergy testing, dermatology, and blood sampling). The MN-based system offers many advantages, such as minimal cost, high medical effectiveness, comparatively good safety, and painless drug application. Drug delivery through MNs can possibly be viewed as a viable instrument for various macromolecules (e.g., proteins, peptides, and nucleic acids) that are not efficiently administered through traditional approaches.
  • 203
  • 08 Aug 2023
Topic Review
Fabrication Methods for Composite Films/Coatings
Chitin is made by joining N-acetyl glucosamine residues through β (1–4) glycosidic linkages and is the second-most prevalent natural polysaccharide after cellulose. Chitosan and its derivatives exhibit anti-hypoxic, adaptogenic, immunostimulant, antiviral, antibacterial, radioprotective, and hemostatic properties. In addition, they are nontoxic, biocompatible, and biodegradable.
  • 416
  • 02 Aug 2023
Topic Review
Faces of Autophagy Inhibition in Cisplatin Therapy
Cisplatin treatment promotes autophagy in both cisplatin-sensitive and cisplatin-resistant cells. Consequently, inhibition of autophagy can be considered a strategy for improving cisplatin chemosensitivity. This is the positive side, which is called Yang. However, the functional activity of cisplatin-induced autophagy is related to different genetic phenotypes and tumor types as well as the microenvironment of the tumor. In addition, preclinical studies have found that pharmacological autophagy inhibitors are not uniformly effective in enhancing the effectiveness of cisplatin and may also exacerbate the side effects of cisplatin toward normal tissue. This is the negative side, which is called Yin. 
  • 500
  • 23 Mar 2022
Topic Review
Factors Affecting Hair Health
Hair health is associated with personal distress and psychological well-being. Even though hair loss (alopecia) does not affect humans’ biological health, it affects an individual’s social well-being. So, treatment for hair problems and improving hair health are obligatory. 
  • 3.3K
  • 07 Feb 2023
Topic Review
Factors Affecting Vitamin C Pharmacokinetics
The pharmacokinetics of vitamin C (vitC) is highly complex. Regulated primarily by a family of saturable sodium dependent vitC transporters (SVCTs), both the absorption and elimination phases display high dose-dependency. Also, tissue specific expression of SVCT subtypes result in a diverse distribution pattern with organ concentrations of vitC at homeostasis ranging from about 0.2 mM up to 10 mM. Unfortunately, the complex pharmacokinetics of vitC has often been overlooked in the design of human intervention studies, giving rise to misinterpretations and erroneous conclusions.
  • 527
  • 23 Sep 2022
Topic Review
Factors Associated with Cancer Metastasis
There are many factors related to cancer metastasis, including angiogenesis, epithelial mesenchymal transition, cancer stem cells, tumor microenvironment, inflammation, genetic and epigenetic factors and extracellular vehicles.
  • 350
  • 19 Jun 2023
Topic Review
FAK as Promising Cancer Therapy
FAK is an intracellular non-receptor tyrosine kinase that promotes tumor cell growth by controlling cell adhesion, migration, proliferation, and survival. Therefore, targeting FAK is considered to be a promising cancer therapy with small molecules.
  • 749
  • 03 Aug 2021
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