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Topic Review
Sinomenine-Type Drugs to Treat Rheumatoid Arthritis
Sinomenine is the main component of the vine Sinomenium acutum. It was first isolated in the early 1920s and has since attracted special interest as a potential anti-rheumatoid arthritis (RA) agent, owing to its successful application in traditional Chinese medicine for the treatment of neuralgia and rheumatoid diseases.
  • 551
  • 23 Dec 2022
Topic Review
Single-Cell Analysis of Metallodrugs
Platinum compounds such as cisplatin (cisPt) embody the backbone of combination chemotherapy protocols against advanced lung cancer. However, their efficacy is primarily limited by inherent or acquired platinum resistance, the origin of which has not been fully elucidated yet, although of paramount interest.
  • 376
  • 09 Sep 2021
Topic Review
Silphium
The chemical composition of three Silphium species in the aspect of the possibility of their use for various purposes has been evaluated. The plant material of three Silphium species (S. perfoliatum, S. trifoliatum and S. integrifolium) was acquired from cultivation located in eastern Poland. The vegetative propagating material consisted of seeds and rhizomes. Content of protein (up to 22.9% in leaves of S. perfoliatum), amino acids (aspartic acid—up to 12.0%, glutamic acid—up to 9.5%, and leucine—up to 9.4%), fat (up to 4.2% in inflorescences of S. perfoliatum), cellulose (up to 42.9% in stems of S. trifoliatum), water-soluble sugars (up to 26.7% in rhizomes of S. perfoliatum) and mineral substances (ash up to 20.9% in stems of S. integrifolium, with significant levels of elements such as K, Ca, Mg, Fe, Mn) in the tested Silphium species can be an important criterion determining a positive evaluation of these plants as sources of alternative raw materials. The conducted research is meant to draw attention to the possibility of use of the biomass of three Silphium species as a potential source of ecological and renewable raw material for food, pharmaceuticals, feed and possibly also for energy generation purposes.
  • 1.7K
  • 02 Nov 2020
Topic Review
Sex-Related Differences in Pharmacological Response to Opioids
Clinical experience proves that pharmacological response may vary between the two sexes since pathophysiological dissimilarities between men and women significantly influence the pharmacokinetics and pharmacodynamics of drugs. Opioids seem to produce better analgesia in women especially when they are administered for a prolonged period of time.
  • 413
  • 15 Jun 2022
Topic Review
Sex Differences in Dopamine Receptors
Dopamine is an important neurotransmitter that plays a key role in neuropsychiatric illness.
  • 594
  • 28 Sep 2021
Topic Review
Sesquiterpene Lactones
Sesquiterpene lactones, a vast group of terpenoids isolated from Asteraceae family species, exhibit a wide variety of biological activities and several of them are already available on the medicines market, such as artemisinin. Here are presented and discussed the most recent and impactful results in vivo, preclinical and clinical studies, involving a selection of ten sesquiterpene lactones (alantolactone, arglabin, costunolide, cynaropicrin, helenalin, inuviscolide, lactucin, parthenolide, thapsigargin and tomentosin) and some of their derivatives.
  • 3.7K
  • 28 Oct 2020
Topic Review
Sertraline in Hemodialysis Patients
Depression and anxiety are the most common psychiatric disorders in end-stage renal disease (ESRD) patients treated with hemodialysis (HD) and may correlate with lower quality of life and increased mortality. Depression treatment in HD patients is still a challenge both for nephrologists and psychiatrists. The possible treatment of depressive disorders can be pharmacological and non-pharmacological. In our article, we focus on the use of sertraline, the medication which seems to be relatively safe and efficient in the abovementioned population, taking under consideration several limitations regarding the use of other selective serotonin reuptake inhibitors (SSRIs).
  • 983
  • 23 Sep 2021
Topic Review
Semisolid Drug Products
Due to complex interdependent relationships affecting their microstructure, topical semisolid drug formulations face unique obstacles to the development of generics compared to other drug products.
  • 659
  • 26 May 2021
Topic Review
Self-Assembling Nucleobase-Containing Peptides
The self-assembly of bio-inspired nanomaterials and biological nanostructures confers new properties and functions to conjugated biomaterials, such as the ability to respond to external stimuli. Nucleobase-containing peptides can be considered as aromatic peptides and, similar to these self-assembling structures, they can lead to interesting functional nanostructures as hereafter explained. Self-assembling nucleopeptides can form hydrogels based on supramolecular structures held by non-covalent molecular interactions occurring between the peptide segments, as well as π–π stacking and Watson–Crick interactions via complementary DNA bases.
  • 709
  • 16 Jun 2021
Topic Review
Selective Cytotoxicity of Ethiopian Plants
Few studies have reported the in vitro anticancer activities of medicinal plants that are collected from different agro‐ecological zones of Ethiopia. Hence, the main aim of this study was to screen the cytotoxic activities of 80% methanol extracts of 22 plants against human peripheral blood mononuclear cells (PBMCs), as well as human breast (MCF‐7), lung (A427), bladder (RT‐4), and cervical (SiSo) cancer cell lines. Active extracts were further screened against human large cell lung carcinoma (LCLC‐103H), pancreatic cancer (DAN‐G), ovarian cancer (A2780), and squamous cell carcinoma of the esophagus (KYSE‐70) by using the crystal violet cell proliferation assay, while the vitality of the acute myeloid leukemia (HL‐60) and histiocytic lymphoma (U‐937) cell lines was monitored in the 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyl‐2H‐tetrazolium bromide (MTT) microtiter assay. Euphorbia schimperiana, Acokanthera schimperi, Kniphofia foliosa, and Kalanchoe petitiana exhibited potent antiproliferative activity against A427, RT‐4, MCF‐7, and SiSo cell lines, with IC50 values ranging from 1.85 ± 0.44 to 17.8 ± 2.31μg/mL. Hence, further studies focusing on bio‐assay‐guided isolation and structural elucidation of active cytotoxic compounds from these plants are warranted.
  • 511
  • 25 Jun 2021
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