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Topic Review
Immunomodulatory Properties of Nigella sativa Seed Extracts
For thousands of years till nowadays, Nigella sativa (NS) has served as a common spice and food preservative. Its seed extracts, seed oil, and essential oil in traditional medicine have been used to remedy many ailments such as headaches, fever, gastric complaints, and even rheumatism. In addition, the antibacterial, virucidal, fungicidal, and antiparasitic properties of NS are well known. However, studies on the possible immunomodulatory effects of black cumin are relatively scarce.
  • 268
  • 06 Jul 2023
Topic Review
The Use of Deferiprone against COVID-19
Deferiprone (L1) is an EMA- and FDA-approved drug used worldwide for the treatment of iron overload and also other conditions where there are no effective treatments. The multi-potent effects and high safety record of L1 in iron loaded and non-iron loaded categories of patients suggests that L1 could be developed as a “magic bullet” drug against COVID-19 and diseases of similar symptomatology.
  • 264
  • 21 Jun 2022
Topic Review
Nanomedicine for Pediatric Healthcare
Pediatrics is the field of medicine that centers on physical, social, and mental health from birth to the end of adolescence. Nanotechnology has received enthusiasm among the scientific community, particularly in medicine and pharmaceutical fields, due to its potential to incorporate diagnostic and treatment tools in the same nanocarrier, enhance targetability to specific organs, decrease toxicity, and potentially reduce treatment schedules. At the same time, it provides a tool to increase patient compliance, which is an essential task concerning the pediatric population.
  • 261
  • 20 Oct 2023
Topic Review
Myeloid Differentiation 88 (MyD88)
Myeloid differentiation 88 (MyD88) is a well-established inflammatory adaptor protein.
  • 260
  • 05 May 2021
Topic Review
Cyanobacterial Chemistry
Several cyanobacterial-derived compounds have been identified with noteworthy inhibitory activity against bacterial, fungal and protozoal growth, as well as viral replication. In addition to the potent cyanotoxins, cyanobacteria also produce a wealth of interesting compounds with therapeutic potential. Perhaps because of the well-established cytotoxicity of some cyanobacterial compounds, the greatest emphasis on cyanobacterial drug research to date has focused on compounds with anticancer activity. However, with the diversity of cyanobacterial compounds already identified, other therapeutic properties should not be neglected. In particular, cyanobacteria contain a wealth of peptides and lipopeptides (both linear and cyclic), as well as lectins, terpenoids and polyphenolic compounds.
  • 260
  • 25 Oct 2023
Topic Review
Mesoporous Silica Nanoparticle-Mediated Drug Delivery in Breast Cancer
Breast cancer (BC) currently occupies the second rank in cancer-related global female deaths. Although consistent awareness and improved diagnosis have reduced mortality, late diagnosis and resistant response still limit the therapeutic efficacy of chemotherapeutic drugs (CDs), leading to relapse with consequent invasion and metastasis. Treatment with CDs is indeed well-versed but it is badly curtailed with accompanying side effects and inadequacies of site-specific drug delivery. As a result, drug carriers ensuring stealth delivery and sustained drug release with improved pharmacokinetics and biodistribution are urgently needed. Core–shell mesoporous silica nanoparticles (MSNPs) have been a cornerstone in this context, attributed to their high surface area, low density, robust functionalization, high drug loading capacity, size–shape-controlled functioning, and homogeneous shell architecture, enabling stealth drug delivery.
  • 261
  • 02 Aug 2023
Topic Review
Blood Microsamples for Therapeutic Drug Monitoring
Therapeutic drug monitoring (TDM) is a specialized area of laboratory medicine which involves the measurement of drug concentrations in biological fluids with the aim of optimizing efficacy and reducing side effects, possibly modifying the drug dose to keep the plasma concentration within the therapeutic range. Plasma and/or whole blood, usually obtained by venipuncture, are the “gold standard” matrices for TDM. Microsampling, commonly used for newborn screening, could also be a convenient alternative to traditional sampling techniques for pharmacokinetics (PK) studies and TDM, helping to overcome practical problems and offering less invasive options to patients.
  • 259
  • 21 Jul 2023
Topic Review
Pharmaceutical Importance of Broccoli
Broccoli (Brassica oleracea L. var. italica) belongs to the Brassicaceae family and has more divided and stalked leaves. It has gained considerable attention due to its remarkable nutritional composition and numerous health benefits. The pharmaceutical importance of broccoli is widely known as antimicrobial, antioxidant, anticancer, immunomodulator, antidiabetic, hepatoprotective, cardioprotective, and anti-amnesic.
  • 258
  • 26 Jul 2023
Topic Review
Dipeptidyl Peptidase 4 Inhibitors
Information on absorption, metabolism and excretion of drugs is necessary to support the studies on their pharmacokinetics and potential drug–drug interactions. Moreover, the knowledge on drug metabolism is one of the crucial factors used to assess their pharmacokinetic profile in patients with some dysfunctions. It is especially important in diabetic patients with higher incidence of chronic liver and kidney problems.
  • 257
  • 27 Jul 2023
Topic Review
Bête Noire of Chemotherapy and Targeted Therapy
Tumor cells struggle to survive following treatment. The struggle ends in either of two ways. The drug combination used for the treatment blocks the proliferation of tumor cells and initiates apoptosis of cells, which is a win for the patient, or tumor cells resist the effect of the drug combination used for the treatment and continue to evade the effect of anti-tumor drugs, which is a bête noire of therapy. Cancer-associated fibroblasts are the most abundant non-transformed element of the microenvironment in solid tumors. Tumor cells play a direct role in establishing the cancer-associated fibroblasts’ population in its microenvironment.
  • 255
  • 31 Mar 2022
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