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Topic Review
Cyclodextrins/Estrogens Inclusion Complexes
In the pharmaceutical industry, cyclodextrins (CDs) are frequently used to improve the aqueous solubility, stability, and bioavailability of medications. Because estrogens have a low polarity, they can interact with some cyclodextrins’ hydrophobic cavities to create inclusion complexes, if their geometric properties are compatible. Estrogen-CD complexes have been widely applied in several fields for various objectives. 
  • 320
  • 09 Jun 2023
Topic Review
Paclitaxel in Bioinspired Nanosystems for Targeted Delivery
Taxanes are a class of diterpenes originally isolated from plants of the yew family (Taxaceae). An intriguing alternative to natural vesicles is represented by bioinspired extracellular vesicle (EV)-like nanoparticles (NPs), for example exosomes (EXOs) obtained from a serial extrusion process of a parent cell membrane suspension through decreasing pore size membranes or from hybridization of EXOs and liposome membranes.
  • 319
  • 18 May 2023
Topic Review
Docking Studies of Recently Synthesized MAO-B Inhibitors
With the significant growth of patients suffering from neurodegenerative diseases (NDs), novel classes of compounds targeting monoamine oxidase type B (MAO-B) are promptly emerging as distinguished structures for the treatment of the latter. As a promising function of computer-aided drug design (CADD), structure-based virtual screening (SBVS) is being heavily applied in processes of drug discovery and development. The utilization of molecular docking, as a helping tool for SBVS, is providing essential data about the poses and the occurring interactions between ligands and target molecules. 
  • 319
  • 13 Jul 2023
Topic Review
Non-Steroidal CYP17A1 Inhibitors and Prostate Cancer
Abiraterone is the only (as of 2021) CYP17A1 inhibitor approved for the treatment of castrate resistant prostate cancer. It is a molecule based on a steroidal scaffold.
  • 318
  • 18 Feb 2022
Topic Review
Advances in Aptamers-Based Applications in Breast Cancer
Aptamers are synthetic single-stranded oligonucleotides (such as RNA and DNA) evolved in vitro using Systematic Evolution of Ligands through Exponential enrichment (SELEX) techniques. Aptamers are evolved to have high affinity and specificity to targets; hence, they have a great potential for use in therapeutics as delivery agents and/or in treatment strategies. Aptamers can be chemically synthesized and modified in a cost-effective manner and are easy to hybridize to a variety of nano-particles and other agents which has paved a way for targeted therapy and diagnostics applications such as in breast tumors.
  • 318
  • 02 Dec 2022
Topic Review
Cannabidiol as a Therapeutical Tool in Dentistry
The medical use of cannabis has a very long history. In the use of cannabinoids, the oral mucosa is the tissue that primarily comes into contact with them and interacts with them. Cannabidiol (CBD) itself is not responsible for the psychotropic effects of cannabis, since it does not produce the typical behavioral effects associated with the consumption of this drug.
  • 319
  • 16 Jun 2023
Topic Review
Novel Fucoidan Pharmaceutical Formulations and Their Potential Application
Fucoidan belongs to a family of sulfated, L-fucose-rich polysaccharides found in the cell wall matrix of various species of marine brown algae (Phaeophyta: Laminariaceae, Fucaceae, Chordariaceae and Alariaceae). Fucoidan can also be obtained from sea cucumbers (Holothuroidea: Stichopodidae, Holothuriidae), sea urchin eggs (Echinoidea: Strongylocentrotidae, Arbaciidae) and sea grasses (Cymodoceaceae).
  • 317
  • 01 Aug 2023
Topic Review
Endocannabinoid Signaling Pathways
Endocannabinoids play an important role as powerful regulators of synaptic function in the central nervous system where they regulate neural functions and behaviors. As fundamental modulators of synaptic function, endocannabinoids can regulate neural functions such as cognition, motor control, pain, and feeding behavior. The interaction between endogenous or exogenous ligands and endocannabinoid receptors initiates signaling pathways.
  • 316
  • 24 Apr 2023
Topic Review
Cancer Chemotherapy Resistance and Mechanism
Cancer is a global burden, and as per the latest GLOBOCAN 2020, over 19.3 and 10 million new cases and deaths occurred in 2020, respectively; female breast cancer has surpassed lung cancer and is now the most commonly diagnosed cancer (11.7%), followed by lung cancer (11.4%), colorectal cancer (10%), and prostate cancer (7.3%). Cancer chemoresistance is a growing concern in medical oncology.
  • 315
  • 18 Oct 2022
Topic Review
Autophagy in Uveal Melanoma
Autophagy is a form of programmed cell degradation that enables the maintenance of homeostasis in response to extracellular stress stimuli. Autophagy is primarily activated by starvation and mediates the degradation, removal, or recycling of cell cytoplasm, organelles, and intracellular components in eukaryotic cells. Autophagy is also involved in the pathogenesis of human diseases, including several cancers. Autophagy mechanisms and mediators have emerged as promising therapeutic targets that could be used to develop new treatment options for uveal melanoma (UM).
  • 315
  • 28 Feb 2024
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